Abstract: A tubular body includes an elongated inner layer that demarcates a main lumen; a wire reinforcing layer that is formed by winding a reinforcing wire around the inner layer; a resinous elongated sub-tube that is arranged so as to extend along a longitudinal direction of the main lumen outside the wire reinforcing layer and demarcates a sub-lumen having a smaller diameter than the main lumen; a resinous outer layer that sheaths the wire reinforcing layer and the sub-tube; and a retaining wire. An operating wire is movably inserted through the sub-lumen, and has a tip connected to a distal portion of the tubular body. An operating part is operated to pull the operating wire to bend the distal portion of the tubular body. The retaining wire is sheathed by the outer layer, and winds together the sub-tube and the wire reinforcing layer.

Abstract: A method for manufacturing a catheter includes a process of supplying a resin material in a melted state to the periphery of a core wire (90) and molding a hollow tube (82) having the core wire (90) inserted thereinto; a process of arranging the hollow tube (82) having the core wire (90) inserted thereinto, on an outer peripheral side of a main lumen forming region of a tubular body part (10) made of resin; a process of extracting the core wire (90) from the inside of the hollow tube (82) to form a sublumen after the core wire (90) inside the hollow tube (82) is elongated and reduced in diameter to peel off the hollow tube (82) and the core wire (90), and a process of inserting an operating wire into the hollow tube (82).

Abstract: The present disclosure provides a catheter including a reinforcing wire layer wound on a main lumen; a first marker having a ring shape, and a second marker having a ring shape and positioned closer to a proximal side than the first marker, each the first and second markers being provided around the reinforcing wire layer and containing a radiopaque metallic material; and an outer layer including the reinforcing wire layer, the first marker, and the second marker. The reinforcing wire layer is formed in a layer beneath the first marker and the second marker, and at least a part of a region between the first marker and the second marker is a non-forming region in which the reinforcing wire layer is not formed.

Abstract: A tubular body includes an elongated inner layer that demarcates a main lumen; a wire reinforcing layer that is formed by winding a reinforcing wire around the inner layer; a resinous elongated sub-tube that is arranged so as to extend along a longitudinal direction of the main lumen outside the wire reinforcing layer and demarcates a sub-lumen having a smaller diameter than the main lumen; a resinous outer layer that sheaths the wire reinforcing layer and the sub-tube; and a retaining wire. An operating wire is movably inserted through the sub-lumen, and has a tip connected to a distal portion of the tubular body. An operating part is operated to pull the operating wire to bend the distal portion of the tubular body. The retaining wire is sheathed by the outer layer, and winds together the sub-tube and the wire reinforcing layer.

Abstract: There is provided a medical device which has favorable operation wire, operability and has a sufficiently reinforced structure around the operation wire. The medical device includes a medical device body; a sub-lumen which is disposed inside the medical device body so as to extend along a longitudinal direction of the medical device body; an operation wire which is inserted into the sub-lumen and extends along the longitudinal direction of the medical device body; and a first tubular reinforcing layer and a second tubular reinforcing layer. The second reinforcing layer is disposed apart from the first reinforcing layer so as to surround the periphery of the first reinforcing layer, and the space between the first reinforcing layer and the second reinforcing layer is filled with a part of a resin constituting the medical device body. The sub-lumen is disposed inside the part of the resin constituting the medical device body.

Abstract: A method for manufacturing a catheter includes a process of supplying a resin material in a melted state to the periphery of a core wire (90) and molding a hollow tube (82) having the core wire (90) inserted thereinto; a process of arranging the hollow tube (82) having the core wire (90) inserted thereinto, on an outer peripheral side of a main lumen forming region of a tubular body part (10) made of resin; a process of extracting the core wire (90) from the inside of the hollow tube (82) to form a sublumen after the core wire (90) inside the hollow tube (82) is elongated and reduced in diameter to peel off the hollow tube (82) and the core wire (90), and a process of inserting an operating wire into the hollow tube (82).

Abstract: A truncated form hepatitis C virus gene wherein part of the gene region encoding from the core protein to the NS2 protein of hepatitis C virus has been deleted while retaining the translation frame. In particular, the gene according to claim 1 wherein said part of the gene region is present in a region encoding at least the E1 protein and the E2 protein.

Abstract: A chimera antigen peptide containing the epitope regions in the core region, the NS3 region, and the NS4 region of the HCV polypeptide. A sensitive detection of a wide range of infection by hepatitis C virus (HCV) can be carried out.

Abstract: The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.

Abstract: This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.

Abstract: This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.