Patents by Inventor Kenneth Lembach

Kenneth Lembach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-2 selective agonists and antagonists
    Patent number: 7105653
    Abstract: The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or 126, whereby said mutein preferentially activates T cells over NK cells. D20H and I, N88G, I, and R, in particular have a relative T cell-differential activity much greater than native IL-2, with predicted associated reduced in vivo toxicity. The invention also includes polynucleotides coding for the muteins of the invention, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions comprising the muteins, and therapeutic methods of treatment.
    Type: Grant
    Filed: April 17, 2004
    Date of Patent: September 12, 2006
    Inventors: Armen B. Shanafelt, Jeffrey M. Greve, Gary Jesmok, Kenneth Lembach, Gayle D. Wetzel