Patents by Inventor Kenneth S. Kosik

Kenneth S. Kosik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS INCLUDING VERTICAL CAVITY SURFACE EMITTING LASERS
    Publication number: 20200259314
    Abstract: A sensing apparatus, an illumination system, and a data communication system including a Vertical Cavity Surface Emitting Laser (VCSEL) or VCSEL array.
    Type: Application
    Filed: October 31, 2018
    Publication date: August 13, 2020
    Applicant: The Regents of the University of California
    Inventors: Jared Kearns, Charles Forman, Dan Cohen, Kenneth S. Kosik, Shuji Nakamura
  • Neural circuit probe
    Patent number: 10488391
    Abstract: A Neural Circuit Probe (NCP) combines a multi-electrode array (MEA) with an automated local probe, wherein the probe is positioned to interact with one or more cells, such as neurons of a neural circuit, grown on or about one or more electrodes of the multi-electrode array. The probe may interact with the cells by electrically recording signals from the multi-electrode array that are assigned to a specific one of the cells. The probe may interact with the cells by locally delivering chemicals to the cells, which transiently and reversibly modulate the electrical behavior of the cells. The probe may interact with the cells by harvesting the cells using a pipette, so that the harvested cells can be sequenced.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: November 26, 2019
    Assignee: The Regents of the University of California
    Inventors: Paul K. Hansma, Kenneth S. Kosik, Luke S. K. Theogarajan, Barney Drake, Daniel C. Bridges, Connor J. Randall, Kenneth R. Tovar
  • NEURAL CIRCUIT PROBE
    Publication number: 20170241976
    Abstract: A Neural Circuit Probe (NCP) combines a multi-electrode array (MEA) with an automated local probe, wherein the probe is positioned to interact with one or more cells, such as neurons of a neural circuit, grown on or about one or more electrodes of the multi-electrode array. The probe may interact with the cells by electrically recording signals from the multi-electrode array that are assigned to a specific one of the cells. The probe may interact with the cells by locally delivering chemicals to the cells, which transiently and reversibly modulate the electrical behavior of the cells. The probe may interact with the cells by harvesting the cells using a pipette, so that the harvested cells can be sequenced.
    Type: Application
    Filed: October 30, 2015
    Publication date: August 24, 2017
    Applicant: The Regents of the University of California
    Inventors: Paul K. Hansma, Kenneth S. Kosik, Luke S.K. Theogarajan, Barney Drake, Daniel C. Bridges, Connor J. Randall, Kenneth R. Tovar
  • Alarm related peptides and nucleic acids and diagnosis using them
    Patent number: 6797511
    Abstract: We have identified a novel protein, named ALARM or &dgr;-catenin, on the basis of its ability to bind to presenilin 1. ALARM contains 4 copies of the arm repeat and is expressed almost exclusively in brain tissue.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: September 28, 2004
    Assignee: Brigham and Women's Hospital
    Inventors: Kenneth S. Kosik, Jianhua Zhou
  • Treatment of alzheimer disease by modulation of synapsins
    Patent number: 6444201
    Abstract: The role of synapsin II in both the reformation and the maintenance of synaptic connections in cultured hippocampal neurons can be the basis of therapy for neurodegenerative disorder, particularly Alzheimer disease, which involve the disruption of synapses. When synapsin II expression in neurons is blocked by antisense synapsin II oligonucleotides, the ability of hippocampal neurons to reform as well as to maintain synapses is severely disrupted. Antisense suppression of synapsin II after axon formation but immediately before synaptogenesis prevents synapse formation. Suppression of synapsin II after synaptogenesis disrupts the majority of existing synapses. Re-expression of synapsin II in synapsin deficient neurons achieved after removing the antisense oligonucleotides leads to the re-establishment of synaptic connections, providing direct evidence that synapsin II is required for the maintenance and/or restoration of synapses.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: September 3, 2002
    Assignees: The Rockefeller University, Brighan and Women's Hospital
    Inventors: Hui-Quan Han, Paul Greengard, Kenneth S. Kosik, Adriana Ferreira
  • Methods and compounds for treating alzheimer's disease
    Patent number: 6403325
    Abstract: Methods for identifying compounds which lower A&bgr; levels by acting through the Wnt signal transduction pathway are disclosed.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: June 11, 2002
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Kenneth S. Kosik, Peter Morin
  • Alarm related peptides and nucleic acids and diagnosis using them
    Patent number: 6258929
    Abstract: We have identified a novel protein, named ALARM or &dgr;-catenin, on the basis of its ability to bind to presenilin 1. ALARM contains 4 copies of the arm repeat and is expressed almost exclusively in brain tissue.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: July 10, 2001
    Assignee: Brigham & Women's Hospital
    Inventors: Kenneth S. Kosik, Jianhua Zhou