Patents by Inventor Kenneth S. Suslick

Kenneth S. Suslick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5512268
    Abstract: In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 30, 1996
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Neil P. Desai, Kenneth S. Suslick, Patrick Soon-Shiong, Paul A. Sandford, Noma R. Merideth
  • Patent number: 5508021
    Abstract: In accordance with the present invention compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: April 16, 1996
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Neil P. Desai, Kenneth S. Suslick, Patrick Soon-Shiong, Paul A. Sandford, Noma R. Merideth
  • Patent number: 5505932
    Abstract: In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 9, 1996
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Neil P. Desai, Kenneth S. Suslick, Patrick Soon-Shiong, Paul A. Sandford, Noma R. Merideth
  • Patent number: 5498421
    Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: March 12, 1996
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
  • Patent number: 5439686
    Abstract: In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: August 8, 1995
    Assignee: VivoRx Pharmaceuticals, Inc.
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Paul A. Sandford, Mark W. Grinstaff, Kenneth S. Suslick
  • Patent number: 5362478
    Abstract: In accordance with the present invention, compositions comprising fluorine-containing magnetic resonance imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI). Fluorinated compounds in general are hydrophobic and as such have limited water solubility; thus the invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery. The shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, fluorocarbon filled polymeric shells of the invention can be used to measure and monitor local oxygen and temperature.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: November 8, 1994
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Paul A. Sandford, Mark W. Grinstaff, Kenneth S. Suslick
  • Patent number: 4010100
    Abstract: An isotope separation method which comprises physically adsorbing an isotopically mixed molecular species on an adsorptive surface and irradiating the adsorbed molecules with radiation of a predetermined wavelength which will selectively excite a desired isotopic species. Sufficient energy is transferred to the excited molecules to desorb them from the surface and thereby separate them from the unexcited undesired isotopic species. The method is particularly applicable to the separation of hydrogen isotopes.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: March 1, 1977
    Assignee: The United States of America as represented by the United States Energy Research and Development Administration
    Inventor: Kenneth S. Suslick