Patents by Inventor Kent Jardemark

Kent Jardemark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8232074
    Abstract: The present invention relates to methods of measuring electrical properties of a cell using electrode devices comprising tapered nanotips having submicrometer dimensions (“nanoelectrodes”) for insertion into a cell. The devices are used to measure electrical properties of the cell and, optionally, may be used to electroporate, the cell or subcellular structures within the cell. The invention also provides arrays of electrode devices having nanotips for simultaneously or sequentially measuring the electrical properties of cells (e.g., such as surface immobilized cells). The electrodes can be used to measure properties of ion channels and in HTS assays to identify drugs which affect the properties of ion channels. The invention additionally provides microfluidic systems adapted for use with the electrode devices having nanotips. In combination with the electrodes, the microfluidic systems provide cell-based biosensors for monitoring cellular responses to conditions, such as exposure to candidate drugs.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: July 31, 2012
    Assignee: Cellectricon AB
    Inventors: Kent Jardemark, Aldo Jesorka, Mattias Karlsson, Jessica Olofsson, Owe Orwar, Johan Pihl, Eskil Sahlin
  • Publication number: 20100143944
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a large number of different solution environments whose characteristics may be known or unknown.
    Type: Application
    Filed: February 25, 2009
    Publication date: June 10, 2010
    Applicant: Cellectricon AB
    Inventors: Owe Orwar, Daniel Chiu, Johan Pihl, Jon Sinclair, Jessica Olofsson, Mattias Karlsson, Kent Jardemark
  • Patent number: 7563614
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a large number of different solution environments whose characteristics may be known or unknown.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: July 21, 2009
    Assignee: Cellectricon AB
    Inventors: Owe Orwar, Daniel Chiu, Johan Pihl, Jon Sinclair, Jessica Olofsson, Mattias Karlsson, Kent Jardemark
  • Publication number: 20090047676
    Abstract: The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.
    Type: Application
    Filed: June 6, 2008
    Publication date: February 19, 2009
    Applicant: Cellectricon AB
    Inventors: Mattias Karlsson, Owe Orwar, Daniel T. Chiu, Jon Sinclair, Kent Jardemark, Jessica Olofsson, Johan Pihl, Cecilia Farre
  • Patent number: 7470518
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying receptors.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: December 30, 2008
    Assignee: Cellectricon AB
    Inventors: Daniel Chiu, Owe Orwar, Kent Jardemark, Mattias Karlsson, Jessica Olofsson, Johan Pihl, Jon Sinclair
  • Patent number: 7390650
    Abstract: The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: June 24, 2008
    Assignee: Cellectricon AB
    Inventors: Mattias Karlsson, Owe Orwar, Daniel T. Chiu, Jon Sinclair, Kent Jardemark, Jessica Olofsson, Johan Pihl, Cecilia Farre
  • Publication number: 20060234298
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying receptors.
    Type: Application
    Filed: January 6, 2005
    Publication date: October 19, 2006
    Inventors: Daniel Chiu, Owe Orwar, Kent Jardemark, Mattias Karlsson, Jessica Olofsson, Johan Pihl, Jon Sinclair
  • Publication number: 20060223164
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a large number of different solution environments whose characteristics may be known or unknown.
    Type: Application
    Filed: January 15, 2003
    Publication date: October 5, 2006
    Inventors: Owe Orwar, Daniel Chiu, Johan Pihl, Jon Sinclair, Jessica Olofsson, Mattias Karlsson, Kent Jardemark
  • Publication number: 20060078961
    Abstract: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a large number of different solution environments whose characteristics may be known or unknown.
    Type: Application
    Filed: January 14, 2003
    Publication date: April 13, 2006
    Inventors: Daniel Chiu, Owe Orwar, Kent Jardemark, Mattias Karlsson, Jessica Olofsson, Johan Pihl, Jon Sinclair
  • Publication number: 20040182707
    Abstract: The present invention relates to methods of measuring electrical properties of a cell using electrode devices comprising tapered nanotips having submicrometer dimensions (“nanoelectrodes”) for insertion into a cell. The devices are used to measure electrical properties of the cell and, optionally, may be used to electroporate, the cell or subcellular structures within the cell. The invention also provides arrays of electrode devices having nanotips for simultaneously or sequentially measuring the electrical properties of cells (e.g., such as surface immobilized cells). The electrodes can be used to measure properties of ion channels and in HTS assays to identify drugs which affect the properties of ion channels. The invention additionally provides microfluidic systems adapted for use with the electrode devices having nanotips.
    Type: Application
    Filed: October 15, 2003
    Publication date: September 23, 2004
    Applicant: Cellectricon AB
    Inventors: Kent Jardemark, Aldo Jesorka, Mattias Karlsson, Jessica Olofsson, Owe Orwar, Johan Pihl, Eskil Sahlin
  • Publication number: 20040110307
    Abstract: The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.
    Type: Application
    Filed: August 20, 2003
    Publication date: June 10, 2004
    Inventors: Mattias Karlsson, Owe Orwar, Daniel T. Chiu, Jon Sinclair, Kent Jardemark, Jessica Olofsson, Johan Pihl, Cecilia Farre
  • Patent number: 6455303
    Abstract: The invention provides a method for detection of receptor- or ion channel-modulators (e.g., antagonists, blockers, etc.). The method comprises fractionating a sample by using a liquid-based separation means (e.g., such as a capillary electrophoresis device), and feeding the fractions containing the modulators directly to a biosensor. The biosensor is activatable by a receptor agonist and produces a measurable response as a result of this activation. Preferably, the agonist is fed to the biosensor through the liquid-based separation means, together with fractions containing the modulators (e.g., antagonists or blockers). The presence of a modulator is detected by monitoring a change in the response of the biosensor, e.g., by measuring changes in electrical properties of the biosensor (such as through patch clamp analysis).
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: September 24, 2002
    Assignee: Cellectricon AB
    Inventors: Owe Orwar, Kent Jardemark