Patents by Inventor Keqiang Li

Keqiang Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9090671
    Abstract: Disclosed are cyclosporine derivatives in which the 3-Sarcosine carbon and 5-Valine nitrogen are each substituted by a non-hydrogen substituent, and their use as pharmaceuticals, in particular for the treatment of hepatitis C virus.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: July 28, 2015
    Assignee: Scynexis, Inc.
    Inventors: Keqiang Li, Ahmed Mamai, Michael Robert Peel
  • Publication number: 20140212381
    Abstract: Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
    Type: Application
    Filed: October 21, 2013
    Publication date: July 31, 2014
    Applicant: Scynexis, Inc.
    Inventors: Keqiang Li, Michael Robert Peel
  • Publication number: 20140213508
    Abstract: Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
    Type: Application
    Filed: October 21, 2013
    Publication date: July 31, 2014
    Applicant: Scynexis, Inc.
    Inventors: Keqiang Li, Michael Robert PEEL
  • Patent number: 8536114
    Abstract: Disclosed herein are compounds of general formula (I): wherein A, B, R1 and R2 are as defined in the specification, and their use as pharmaceuticals.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: September 17, 2013
    Assignee: Scynexis, Inc.
    Inventors: Keqiang Li, David Renwick Houck, Cyprian Okwara Ogbu, Michael Robert Peel, Andrew William Scribner
  • Patent number: 8329658
    Abstract: This invention provides compounds of general formula (I): wherein A, B, R1, R2 and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus and/or human immunodeficiency virus.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: December 11, 2012
    Assignee: Scynexis, Inc.
    Inventors: David Renwick Houck, Keqiang Li
  • Publication number: 20110144005
    Abstract: Compounds are disclosed of general formula (I): wherein A, B, R1 and R2 are as defined in the description, and their use as pharmaceuticals.
    Type: Application
    Filed: December 9, 2010
    Publication date: June 16, 2011
    Inventors: Keqiang Li, Michael Robert Peel
  • Publication number: 20100173836
    Abstract: Disclosed herein are compounds of general formula (I): wherein A, B, R1 and R2 are as defined in the specification, and their use as pharmaceuticals.
    Type: Application
    Filed: December 30, 2009
    Publication date: July 8, 2010
    Inventors: Keqiang Li, David Renwick Houck, Cyprian Okwara Ogbu, Michael Robert Peel, Andrew William Scribner
  • Publication number: 20090312300
    Abstract: Disclosed are cyclosporine derivatives in which the 3-Sarcosine carbon and 5-Valine nitrogen are each substituted by a non-hydrogen substituent, and their use as pharmaceuticals, in particular for the treatment of hepatitis C virus.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 17, 2009
    Inventors: Keqiang Li, Ahmed Mamai, Michael Robert Peel
  • Publication number: 20090306033
    Abstract: Compounds are disclosed of general formula (I): wherein A, B and R1 are as defined in the description, and their use as pharmaceuticals.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 10, 2009
    Inventors: Keqiang Li, Ahmed Mamai, Michael Robert Peel
  • Publication number: 20090298751
    Abstract: This invention provides compounds of general formula (T): (I) wherein A, B, R1, R2, and X are as defined in this specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus and/or human immunodeficiency virus.
    Type: Application
    Filed: October 2, 2006
    Publication date: December 3, 2009
    Applicant: SCYNEXIS, INC.
    Inventors: David Renwick Houck, Keqiang Li
  • Patent number: 6809207
    Abstract: The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, or thienyl group. The present invention further provides a method for synthesizing alpha-amino acids and derivatives thereof via a modified Ugi type reaction using an aldehyde, ammonium formate and a C1-C5 alkyl isocyanide. The compounds provided by this method are useful in the development of new pharmaceuticals for the treatment of human diseases.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: October 26, 2004
    Assignee: PharmaCore, Inc.
    Inventors: Sekar Alla, Seung-Yong Choi, Dale Dhanoa, Elso DiFranco, Galina Krokhina, Keqiang Li, Balasubramanian Thiagarajan, Wen-Chun Zhang
  • Patent number: 6713580
    Abstract: The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be linked to solid supports. These templates make possible the production of novel classes of chemical compounds through a plurality of chemical reactions. The templates are advantageous for use in drug discovery regimes.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 30, 2004
    Assignee: Pharmacore, Inc.
    Inventors: Michael Johnson, Keqiang Li, Elso DiFranco, Daljit S. Dhanoa
  • Publication number: 20030064976
    Abstract: The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. The present invention also provides a novel method for the synthesis of alpha-amino acids and derivatives thereof.
    Type: Application
    Filed: July 24, 2002
    Publication date: April 3, 2003
    Inventors: Sekar Alla, Seung-Yong Choi, Dale Dhanoa, Elso DiFranco, Galina Krokhina, Keqiang Li, Thiagarajan Balasubramanian, Wen-Chun Zhang
  • Patent number: 6291409
    Abstract: A process for modifying an unsaturated polyol fatty acid ester stock, such as an unsaturated triacylglycerol oil, to enhance its fluidity and/or oxidative stability is provided. The method includes reacting the unsaturated polyol fatty acid ester stock with cyclopropanating agent. Lubricants containing cyclopropanated polyol fatty acid ester and methods for their production and use are also provided.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: September 18, 2001
    Assignee: Cargill, Inc.
    Inventors: Dharma R. Kodali, Keqiang Li
  • Patent number: 6150540
    Abstract: A tetrahydrofuran (THF) epoxide and method of its preparation according to a novel stereoselective synthetic method. The compounds of the invention are used to prepare therapeutically active mono-THF and bis-THF containing Annonaceous Acetogenins.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: November 21, 2000
    Assignee: Hughes Institute
    Inventors: Fatih M. Uckun, Keqiang Li, Shyi-Tai Jan
  • Patent number: 6051539
    Abstract: A process for modifying an unsaturated polyol fatty acid ester stock, such as an unsaturated triacylglycerol oil, to enhance its fluidity and/or oxidative stability is provided. The method includes reacting the unsaturated polyol fatty acid ester stock with cyclopropanating agent. Lubricants containing a modified unsaturated polyol fatty acid ester and methods for their production and use are also provided.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: April 18, 2000
    Assignee: Cargill, Inc.
    Inventors: Dharma R. Kodali, Keqiang Li
  • Patent number: 5914410
    Abstract: Novel tetrahydrofuran-epoxide compounds are described as intermediates for the preparation of non-adjacent bis-THF-acetogenins of pharmaceutical interest. Also described is a novel stereocontrolled synthesis for preparing such intermediates starting with commercially available enantiomers of glycidyl benzylether.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: June 22, 1999
    Assignee: Wayne Hughes Institute
    Inventors: Keqiang Li, Faith M. Uckun