Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis of the medical probe. The medical probe further comprises an expandable basket assembly coupled to the distal end of the tubular shaft. The basket assembly comprises a plurality of spines and a plurality of electrodes. The electrode comprises an electrode body that defines a lumen therethrough such that the respective spine extends through the lumen. The respective electrode body comprises two sections that define a lengthwise direction of the electrode body section that are inclined inward with respect to a central axis of the respective electrode.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis of the medical probe. The medical probe further comprises an expandable basket assembly coupled to the distal end of the tubular shaft. The basket assembly comprises a plurality of spines and a plurality of electrodes. The electrode comprises an electrode body that defines a lumen therethrough such that the respective spine extends through the lumen. The basket assembly comprises an electrically insulative jacket disposed between each respective spine and each respective electrode. Each electrode body and electrically insulative jacket comprises a substantially circular cross-sectional shape.

Abstract: The disclosed technology includes an expandable basket assembly for a medical probe, which may include a single unitary structure including a plurality of spines converging at a central spine intersection. The central spine intersection being positioned on a longitudinal axis of the expandable basket assembly at a distal end thereof. The single unitary structure may include a plurality of radial cutouts with each radial cutout defining an opening in each of the plurality of spines proximate the central spine intersection so that each opening extends for a length along each spine away from the central spine intersection.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis and including a proximal end and a distal end. The medical probe further comprises an expandable basket assembly proximate the distal end of the tubular shaft. The basket assembly comprises a plurality of C-shaped spines and one or more electrodes coupled to each of the spines, each electrode defining a lumen through the electrode so that a spine extends through the lumen of each of the one or more electrodes. The spines converge at a central spine intersection at a distal end of the basket assembly. Each spine comprises a respective end connected to the distal end of the tubular shaft.

Abstract: The disclosed technology includes a medical probe including a tubular shaft having a proximal end and a distal end. The tubular shaft can extend along a longitudinal axis. The medical probe can include an expandable basket assembly proximate the distal end of the tubular shaft. The expandable basket assembly can include a single spine comprising a resilient material extending generally linearly along the longitudinal axis in a collapsed form and forming a spiral member defining a generally spherical outer periphery in an expanded form. One or more electrodes can be coupled to the single spine. Each electrode can include a lumen offset with respect to a centroid of the electrode so that the single spine extends through the lumen of each of the one or more electrodes.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis and including a proximal end and a distal end. The medical probe further comprises an expandable basket assembly proximate the distal end of the tubular shaft. The basket assembly comprises a single unitary structure that includes a plurality of linear spines formed from a planar sheet of material and one or more electrodes coupled to each of the spines, each electrode defining a lumen through the electrode so that a spine extends through the lumen of each of the one or more electrodes. The spines converge at a central spine intersection at a distal end of the basket assembly. The central spine intersection includes one or more cutouts that allows for bending of the spines. Each spine comprises a respective end connected to the distal end of the tubular shaft.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft having a proximal end and a distal end, the tubular shaft extending along a longitudinal axis. The medical probe further comprises an expandable basket assembly coupled to the distal end of the tubular shaft. The basket assembly includes a plurality of electrodes with each electrode of the plurality of electrodes having a lumen therethrough. The basket assembly further includes a plurality of spines extending along the longitudinal axis and configured to bow radially outward from the longitudinal axis when the expandable basket assembly is transitioned from a collapsed form to an expanded form. Each spine includes a proximal and a distal end and a strut passing through the lumen of an electrode. The strut includes a mechanical retainer disposed on the strut to prevent the electrode from sliding proximally or distally along a length of the spine.

Abstract: The disclosed technology includes a medical probe including a tubular shaft having an expandable basket assembly coupled to a distal end of the tubular shaft. The basket assembly can have at least one spine extending along a longitudinal axis and configured to bow radially outward from the longitudinal axis when the basket assembly is transitioned from a collapsed form to an expanded form. The basket assembly can include electrode assemblies each attached to the spine. Each electrode assembly includes an electrode and a first and second electrically insulating portion that electrically isolate the electrode from the spine. The electrode, the first electrically insulating portion, and the second electrically insulating portion are interlocked onto the spine such that the plurality of electrode assemblies are prevented from sliding proximally or distally along a length of the spine.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis and including a proximal end and a distal end. The medical probe further comprises an expandable basket assembly proximate the distal end of the tubular shaft. The basket assembly comprises a first unitary tripodic structure and a second unitary tripodic structure, each tripodic structure formed from a respective planar sheet of material that includes three linear spines converging at a respective central spine intersection and one or more electrodes coupled to each of the spines, each electrode defining a lumen through the electrode so that the spine extends through the lumen of each of the one or more electrodes. Each tripodic structure formed from a respective planar sheet of material that includes three linear spines converging at a respective central spine intersection.

Abstract: The disclosed technology includes a medical probe comprising a tubular shaft extending along a longitudinal axis and including a proximal end and a distal end. The medical probe further comprises an expandable basket assembly proximate the distal end of the tubular shaft. The basket assembly comprises a single unitary structure that includes a plurality of linear spines formed from a planar sheet of material and one or more electrodes coupled to each of the spines, each electrode defining a lumen through the electrode so that a spine extends through the lumen of each of the one or more electrodes. The spines converge at a central spine intersection at a distal end of the basket assembly. The central spine intersection includes one or more cutouts that allows for bending of the spines. Each spine comprises a respective end connected to the distal end of the tubular shaft.

Abstract: Wiring is disclosed herein that is configured to supply IRE ablation signals through a catheter body and is resistant against dielectric breakdown, arcing, and noise during ablation. The wiring includes a highly conductive core, a conductive cover surrounding the core that has lower electrical and/or thermal conductivity than the core, and an insulative jacket surrounding the conductive cover. A catheter including such wiring may be suitable for supplying electrical signals to tissue to perform IRE ablation. In some examples, such a catheter can also be suitable for reversible electroporation and/or RF ablation.

Abstract: A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. Each of the disk, lever and ring actuators are of a design that allows existing control handles and catheters to be readily modified to include these actuators.

Abstract: A computer-implemented method is provided for improving live video quality. The method comprises: (a) acquiring, using a medical imaging apparatus, a stream of consecutive image frames of a subject; (b) feeding the stream of consecutive image frames to a first set of denoising components, wherein each of the first set of denoising components is configured to denoise an image frame from the stream of consecutive image frames in a spatial domain to output an intermediate image frame; (c) feeding a plurality of the intermediate image frames to a second denoising component, wherein the second denoising component is configured to (i) denoise the plurality of the intermediate image frames in a temporal domain and (ii) generate a weight map; and outputting a final image frame with improved quality in both temporal domain and spatial domain based at least in part on the weight map.

Abstract: A patch and sensor assembly has a biosensor housed in a reusable portion that connects to a mapping and localization system (MLS) via biosensor wires. A disposable portion has an electrode layer through which signals are transmitted to the MLS via ACL wires. The biosensor and ACL wires extend through a single cable exiting the reusable portion. The disposable portion includes an adhesive layer for adhering the electrode layer to a patient, on the electrode layer, and an engagement element for detachably receiving at least a portion of the housing of the reusable portion. The reusable portion includes a housing in which the biosensor has biosensor wires that exit the reusable portion. The housing is also adapted to carry and/or provide support to an ACL contact member responsive to the electrode layer of the disposable portion, and ACL wires that exit the reusable portion.

Abstract: A medical probe includes a generally tubular member with a tip portion coupled to the tubular member. A puller wire is disposed in the tubular member and configured for movement along the longitudinal axis to bend the tip portion with respect to the longitudinal axis. An anchor is disposed within the tubular member and connected to the puller wire such that the anchor has a t-bar. The t-bar includes a generally transverse extension and a ferrule connected to the puller wire. The probe includes a fiber engaged to the generally transverse extension and extending distally into the probe to increase a strength of the anchor with respect to forces applied to the puller wire to deflect the tip of the medical probe.

Abstract: A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. Each of the disk, lever and ring actuators are of a design that allows existing control handles and catheters to be readily modified to include these actuators.

Abstract: Examples presented herein generally include a catheter and a system configured to deliver electrical pulses for ablation by IRE and methods for constructing and using the same. The catheter and system can further be configured to delivery RF electrical current for thermal ablation interleaved with ablation by IRE, simultaneously with ablation by IRE, and/or separately from ablation by IRE. The catheter can have a linear distal portion with a tip electrode, a middle ring electrode, and a proximal ring electrode. The electrodes be configured in several combinations to provide unipolar ablation, bipolar ablation, and/or a combination thereof.

Abstract: A catheter can have a distal circular region that can contract in circumference via manipulation of a pull wire. The circular region can have electrodes distributed around the circumference that are suitable for mapping and/or ablation, and preferably suitable for IRE ablation. The catheter can include a cross-over region near a distal end of a shaft in which elongated elements extend at an angle to the longitudinal axis. The cross-over region can be bounded by an intermediate tube having four lumens and a distal tube having three lumens. The circular region can include structural features to facilitate contraction such as a support member having a preferable bending direction, polymer tubing segments positioned to inhibit bending stress on electrodes, navigation sensors positioned to inhibit bending stress on said sensors and electrodes, and a distal assembly at a distal end of the circular region.

Abstract: A medical probe includes a generally tubular member with a tip portion coupled to the tubular member. A puller wire is disposed in the tubular member and configured for movement along the longitudinal axis to bend the tip portion with respect to the longitudinal axis. An anchor is disposed within the tubular member and connected to the puller wire such that the anchor has a t-bar. The t-bar includes a generally transverse extension and a ferrule connected to the puller wire. The t-bar has a polymeric member disposed on the generally transverse extension to increase a strength of the anchor with respect to forces applied to the puller wire to deflect the tip of the medical probe.

Abstract: A patch and sensor assembly has a biosensor housed in a reusable portion that connects to a mapping and localization system (MLS) via biosensor wires. A disposable portion has an electrode layer through which signals are transmitted to the MLS via ACL wires. The biosensor and ACL wires extend through a single cable exiting the reusable portion. The disposable portion includes an adhesive layer for adhering the electrode layer to a patient, on the electrode layer, and an engagement element for detachably receiving at least a portion of the housing of the reusable portion. The reusable portion includes a housing in which the biosensor has biosensor wires that exit the reusable portion. The housing is also adapted to carry and/or provide support to an ACL contact member responsive to the electrode layer of the disposable portion, and ACL wires that exit the reusable portion.