Patents by Inventor Kevin J. Edgar
Kevin J. Edgar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250101139Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.Type: ApplicationFiled: December 9, 2024Publication date: March 27, 2025Inventors: Kevin J. Edgar, Brittany L.B. Nichols, Junyi Chen, Charles Frazier, Ann Norris
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Patent number: 12162962Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.Type: GrantFiled: June 9, 2022Date of Patent: December 10, 2024Assignees: Virginia Tech Intellectual Properties, Inc., Purdue Research FoundationInventors: Kevin J. Edgar, Brittany L. B. Nichols, Junyi Chen, Charles Frazier, Lynne S. Taylor, Laura I. Mosquera-Giraldo, Ann Norris
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Publication number: 20220298265Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.Type: ApplicationFiled: June 9, 2022Publication date: September 22, 2022Inventors: Kevin J. Edgar, Brittany L.B. Nichols, Junyi Chen, Charles Frazier, Lynne S. Taylor, Laura I. Mosquera-Giraldo, Ann Norris, Benjamin Adams
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Patent number: 10851179Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.Type: GrantFiled: March 16, 2015Date of Patent: December 1, 2020Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. Edgar, Xiangtao Meng, Yifan Dong
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Patent number: 10738134Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.Type: GrantFiled: September 26, 2014Date of Patent: August 11, 2020Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. Edgar, Xiangtao Meng, John Matson
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Patent number: 9708415Abstract: The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from —H, —COR?, —R??, or —COR? COOH, with the proviso that at least one of the R1, R2, or R3 is —COR? COOH; R? is an alkyl, alkenyl, alkynyl, or aromatic group; R? is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (?C4); and R?? is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.Type: GrantFiled: September 21, 2010Date of Patent: July 18, 2017Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. Edgar, Nilanjana Kar
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Publication number: 20160376379Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.Type: ApplicationFiled: March 16, 2015Publication date: December 29, 2016Applicant: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. Edgar, Xiangtao Meng, Yifan Dong
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Publication number: 20160215068Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose co-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.Type: ApplicationFiled: September 26, 2014Publication date: July 28, 2016Applicant: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. EDGAR, Xiangtao MENG, John MATSON
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Publication number: 20150004237Abstract: Provided are cellulose esters useful for inhibiting solution crystallization of drugs. Specific polymers include cellulose esters of formula I: wherein n of the ?-carboxyalkanoyl group, is 3, 4, 6, or 8 to provide a ?-carboxyalkanoyl group chosen from succinoyl, glutaroyl, adipoyl, sebacyl, and suberyl groups; and wherein R is chosen from: a hydrogen atom; and an alkanoyl group chosen from acetyl, propionyl, butyryl, valeroyl, hexanoyl, nonanoyl, decanoyl, lauroyl, palmitoyl, and stearoyl groups; wherein there is a total degree of substitution of the alkanoyl group and the ?-carboxyalkanoyl group of at least 2.0; and wherein the polymer comprises m repeating units where n=1 to 1,000,000, or 10 to 100,000, or 100 to 1,000, such as 1 to 6,000. Embodiments further include compositions comprising cellulose esters and poorly water-soluble drugs, which compositions exhibit greater solubility and stability in solution as compared to the drugs alone.Type: ApplicationFiled: January 9, 2013Publication date: January 1, 2015Inventors: Kevin J. Edgar, Bin Li, Lynne Taylor, Grace Ilevbare, Stephanie M. Williams, Haoyu Liu
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Publication number: 20130237609Abstract: The present invention relates to delivery systems to enhance the bioavailability of flavonoids to improve human health. Flavonoids of interest include but are not limited to curcumin, resveratrol, ellagic acid, naringenin, and quercetin. Flavonoids are important in part because they are known to have beneficial effects on human health, including cardioprotective, antioxidant, and anticancer effects. Utility has been limited by low bioavailability, both in the sense of requiring high doses and in that it has been difficult to carry out proper dose-response studies in the absence of methods to control the actual dose administered. In addition to pharmaceutical applications, there are potential nutraceutical uses, for example in supplements that might be sold in health food stores and pharmacies.Type: ApplicationFiled: October 19, 2011Publication date: September 12, 2013Inventors: Kevin J. Edgar, Bin Li, Lynne Taylor, Grace Ilevbare, Stephanie M. Williams
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Publication number: 20120197011Abstract: The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from —H, —COR?, —R??, or —COR? COOH, with the proviso that at least one of the R1, R2, or R3 is —COR? COOH; R? is an alkyl, alkenyl, alkynyl, or aromatic group; R? is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (?C4); and R?? is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.Type: ApplicationFiled: September 21, 2010Publication date: August 2, 2012Applicant: Virginia Tech Intellectual Properties, Inc.Inventors: Kevin J. Edgar, Nilanjana Kar
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Patent number: 7276546Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.Type: GrantFiled: May 17, 2005Date of Patent: October 2, 2007Assignee: Eastman Chemical CompanyInventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
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Patent number: 6977275Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.Type: GrantFiled: January 10, 2003Date of Patent: December 20, 2005Assignee: Eastman Chemical CompanyInventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
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Publication number: 20030171458Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.Type: ApplicationFiled: January 10, 2003Publication date: September 11, 2003Inventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
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Patent number: 6160111Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process comprising contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) an insoluble sulfonic acid resin catalyst.Type: GrantFiled: December 2, 1996Date of Patent: December 12, 2000Assignee: Eastman Chemical CompanyInventor: Kevin J. Edgar
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Patent number: 5929229Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process consisting of contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) a titanium-containing compound.Type: GrantFiled: March 6, 1998Date of Patent: July 27, 1999Assignee: Eastman Chemical CompanyInventors: Kevin J. Edgar, Richard T. Bogan
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Patent number: 5750677Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process comprising contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) a titanium-containing compound.Type: GrantFiled: December 30, 1994Date of Patent: May 12, 1998Assignee: Eastman Chemical CompanyInventors: Kevin J. Edgar, Richard T. Bogan
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Patent number: 5597912Abstract: Process for reducing the degree of substitution of cellulose esters employing carboxylic acids as solvolysis promoters is disclosed. Exemplary cellulose esters are cellulose acetate, cellulose propionate, cellulose butyrate, cellulose acetate propionate, and cellulose acetate butyrate.Type: GrantFiled: March 4, 1994Date of Patent: January 28, 1997Assignee: Eastman Chemical CompanyInventors: Kevin J. Edgar, Charles M. Buchanan
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Patent number: 5595591Abstract: Water soluble or water-dispersible cellulose acetoacetate esters are prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof and a carboxylic anhydride in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetate esters are useful for coatings applications.Type: GrantFiled: March 1, 1996Date of Patent: January 21, 1997Assignee: Eastman Chemical ComanyInventors: Kevin J. Edgar, Jonathan E. Lawniczak
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Patent number: 5521304Abstract: Water soluble or water-dispersible cellulose acetoacetate esters are prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof and a carboxylic anhydride in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetate esters are useful for coatings applications.Type: GrantFiled: February 27, 1995Date of Patent: May 28, 1996Assignee: Eastman Chemical CompanyInventors: Kevin J. Edgar, Jonathan E. Lawniczak