Patents by Inventor Kevin J. Edgar

Kevin J. Edgar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10851179
    Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: December 1, 2020
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. Edgar, Xiangtao Meng, Yifan Dong
  • Patent number: 10738134
    Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 11, 2020
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. Edgar, Xiangtao Meng, John Matson
  • Patent number: 9708415
    Abstract: The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from —H, —COR?, —R??, or —COR? COOH, with the proviso that at least one of the R1, R2, or R3 is —COR? COOH; R? is an alkyl, alkenyl, alkynyl, or aromatic group; R? is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (?C4); and R?? is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: July 18, 2017
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. Edgar, Nilanjana Kar
  • Publication number: 20160376379
    Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ?-carboxyesters via olefin cross-metathesis with acrylates is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate acrylate partners appear to follow Grubbs rules as summarized herein. Additionally, a method of hydrogenation of the cross-metathesized product is described. The compounds and methods may be useful for waterborne coating applications, adhesives, lubricants, or any product in need of dispersion in an aqueous media.
    Type: Application
    Filed: March 16, 2015
    Publication date: December 29, 2016
    Applicant: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. Edgar, Xiangtao Meng, Yifan Dong
  • Publication number: 20160215068
    Abstract: Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose co-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.
    Type: Application
    Filed: September 26, 2014
    Publication date: July 28, 2016
    Applicant: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. EDGAR, Xiangtao MENG, John MATSON
  • Publication number: 20150004237
    Abstract: Provided are cellulose esters useful for inhibiting solution crystallization of drugs. Specific polymers include cellulose esters of formula I: wherein n of the ?-carboxyalkanoyl group, is 3, 4, 6, or 8 to provide a ?-carboxyalkanoyl group chosen from succinoyl, glutaroyl, adipoyl, sebacyl, and suberyl groups; and wherein R is chosen from: a hydrogen atom; and an alkanoyl group chosen from acetyl, propionyl, butyryl, valeroyl, hexanoyl, nonanoyl, decanoyl, lauroyl, palmitoyl, and stearoyl groups; wherein there is a total degree of substitution of the alkanoyl group and the ?-carboxyalkanoyl group of at least 2.0; and wherein the polymer comprises m repeating units where n=1 to 1,000,000, or 10 to 100,000, or 100 to 1,000, such as 1 to 6,000. Embodiments further include compositions comprising cellulose esters and poorly water-soluble drugs, which compositions exhibit greater solubility and stability in solution as compared to the drugs alone.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 1, 2015
    Inventors: Kevin J. Edgar, Bin Li, Lynne Taylor, Grace Ilevbare, Stephanie M. Williams, Haoyu Liu
  • Publication number: 20130237609
    Abstract: The present invention relates to delivery systems to enhance the bioavailability of flavonoids to improve human health. Flavonoids of interest include but are not limited to curcumin, resveratrol, ellagic acid, naringenin, and quercetin. Flavonoids are important in part because they are known to have beneficial effects on human health, including cardioprotective, antioxidant, and anticancer effects. Utility has been limited by low bioavailability, both in the sense of requiring high doses and in that it has been difficult to carry out proper dose-response studies in the absence of methods to control the actual dose administered. In addition to pharmaceutical applications, there are potential nutraceutical uses, for example in supplements that might be sold in health food stores and pharmacies.
    Type: Application
    Filed: October 19, 2011
    Publication date: September 12, 2013
    Inventors: Kevin J. Edgar, Bin Li, Lynne Taylor, Grace Ilevbare, Stephanie M. Williams
  • Publication number: 20120197011
    Abstract: The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from —H, —COR?, —R??, or —COR? COOH, with the proviso that at least one of the R1, R2, or R3 is —COR? COOH; R? is an alkyl, alkenyl, alkynyl, or aromatic group; R? is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (?C4); and R?? is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.
    Type: Application
    Filed: September 21, 2010
    Publication date: August 2, 2012
    Applicant: Virginia Tech Intellectual Properties, Inc.
    Inventors: Kevin J. Edgar, Nilanjana Kar
  • Patent number: 7276546
    Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: October 2, 2007
    Assignee: Eastman Chemical Company
    Inventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
  • Patent number: 6977275
    Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: December 20, 2005
    Assignee: Eastman Chemical Company
    Inventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
  • Publication number: 20030171458
    Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 11, 2003
    Inventors: Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, Juanelle L. Lambert
  • Patent number: 6160111
    Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process comprising contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) an insoluble sulfonic acid resin catalyst.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: December 12, 2000
    Assignee: Eastman Chemical Company
    Inventor: Kevin J. Edgar
  • Patent number: 5929229
    Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process consisting of contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) a titanium-containing compound.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: July 27, 1999
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, Richard T. Bogan
  • Patent number: 5750677
    Abstract: The present invention relates to a process for preparing cellulose esters having a total DS/AGU of 0.1 to 3.0, said process comprising contacting the following:(i) a cellulose material,(ii) a solubilizing amount of a solvent system comprising a carboxamide diluent or a urea-based diluent,(iii) an acylating reagent, and(iv) a titanium-containing compound.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: May 12, 1998
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, Richard T. Bogan
  • Patent number: 5597912
    Abstract: Process for reducing the degree of substitution of cellulose esters employing carboxylic acids as solvolysis promoters is disclosed. Exemplary cellulose esters are cellulose acetate, cellulose propionate, cellulose butyrate, cellulose acetate propionate, and cellulose acetate butyrate.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: January 28, 1997
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, Charles M. Buchanan
  • Patent number: 5595591
    Abstract: Water soluble or water-dispersible cellulose acetoacetate esters are prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof and a carboxylic anhydride in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetate esters are useful for coatings applications.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: January 21, 1997
    Assignee: Eastman Chemical Comany
    Inventors: Kevin J. Edgar, Jonathan E. Lawniczak
  • Patent number: 5521304
    Abstract: Water soluble or water-dispersible cellulose acetoacetate esters are prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof and a carboxylic anhydride in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetate esters are useful for coatings applications.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: May 28, 1996
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, Jonathan E. Lawniczak
  • Patent number: 5420267
    Abstract: Water soluble or water-dispersible cellulose acetoacetate esters are prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof and a carboxylic anhydride in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetate esters are useful for coatings applications.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: May 30, 1995
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, Jonathan E. Lawniczak
  • Patent number: 5360843
    Abstract: Water soluble cellulose acetoacetates prepared by contacting a cellulose material with diketene, an alkyl acetoacetate, 2,2,6-trimethyl-4H-1,3-dioxin-4-one or a mixture thereof in a solvent system comprising lithium chloride plus a carboxamide. Compositions containing the cellulose acetoacetates and, optionally, a crosslinking agent are useful for coatings applications.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: November 1, 1994
    Assignee: Eastman Chemical Company
    Inventors: Kevin J. Edgar, William W. Blount, Jr.
  • Patent number: 5302637
    Abstract: There are provided novel miscible blend compositions comprising (a) a cellulose ester and (b) a vinylphenol containing polymer. The blends do not exhibit large scale phase separation and provide properties which are essentially intermediate between those of either cellulose ester or vinylphenol containing polymers. The blends are useful for both molded and film applications as well as for coatings.
    Type: Grant
    Filed: July 22, 1992
    Date of Patent: April 12, 1994
    Assignee: Eastman Kodak Company
    Inventors: Christine J. T. Landry, David M. Teegarden, Kevin J. Edgar, Stephen S. Kelley