Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.

Abstract: Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer.

Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.

Abstract: System, devices and methods for the fabrication of polymeric fibers, as well as resulting polymeric fibers, polymeric fiber materials and uses thereof are described. The polymeric fibers include poly(para-phenylene terephthalamide) (PPTA) fibers having an average fiber diameter in a range of 300 nm to 3 ?m, and having an average Young's modulus in a range of 1 GPa to 100 GPa. Some materials including a plurality of the polymeric fibers have a thermal conductivity (k) in a range of 0.005 W/(m·K) to 10 W/(m·K) as measured perpendicular to a plane of the material.

Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.

Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.

Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.

Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: Systems and methods are provided including a housing configured to receive and engage a hollow tissue structure within a fluid chamber of the housing. A first pair of flow channels and a second pair of flow channels of the housing are fluidly coupled to the fluid chamber. The housing fluidly couples the first pair of flow channels and fluidly couples the second pair of flow channels via a second flow path such that a change in a fluid pressure differential between a first fluid in the first flow path and a second fluid in the second flow path deflects at least a portion of the hollow tissue structure causing a change in flow of the first fluid through the first pair of flow channels or a change in flow of the second fluid through the second pair of flow channels.

Abstract: The present invention provides methods for optically micropatterning hydrogels, which may be used for, e.g., regenerative medicine, synthetic or cultured foods, and in devices suitable for use in high throughput drug screening assays.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The present invention provides methods for preparing an alpha-keratin solution comprising alpha-keratin protofibrils and intermediate filaments in liquid crystal phase and uses thereof for fabricating, e.g., shape-memory polymeric fibers, yarns, threads, fabrics, structures and objects.

Abstract: The present invention provides engineered valves, tubular structures, and sheets comprising oriented polymeric fibers, e.g., nanofibers, methods of fabricating such structures, and methods of use of such structures as, for example, patches, grafts and valves, e.g., cardiac valves.

Abstract: Some embodiments provide a microfluidic cartridge for automatically hydrodynamically loading objects (e.g., cell clusters) into traps in parallel trapping channels with one object per trap, methods of making such cartridges and methods of use of C such cartridges.

Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).