Patents by Inventor Kevin Kit Parker

Kevin Kit Parker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12043922
    Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: July 23, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Grant Michael Gonzalez, Holly M. Golecki, Kwanwoo Shin, Josue A. Goss
  • Publication number: 20240182868
    Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
    Type: Application
    Filed: February 12, 2024
    Publication date: June 6, 2024
    Inventors: Donald E. Ingber, Kevin Kit Parker, Geraldine A. Hamilton, Anthony Bahinski
  • Publication number: 20230348831
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Application
    Filed: June 30, 2023
    Publication date: November 2, 2023
    Inventors: Donald E. Ingber, Anthony M. Bahinski, Robert Cunningham, Josue A. Goss, Geraldine A. Hamilton, Christopher David Hinojosa, Daniel Levner, Kevin Kit Parker
  • Patent number: 11773359
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: October 3, 2023
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. Ingber, Anthony Bahinski, Robert Cunningham, Josue A. Goss, Geraldine A. Hamilton, Christopher David Hinojosa, Daniel Levner, Kevin Kit Parker
  • Publication number: 20230287318
    Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Benjamin D. Pope, Kevin Kit Parker
  • Publication number: 20230243812
    Abstract: Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer.
    Type: Application
    Filed: January 13, 2023
    Publication date: August 3, 2023
    Inventors: Gilyong Lee, Sung-Jin Park, Kevin Kit Parker, Andre G. Kleber
  • Patent number: 11629318
    Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: April 18, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Benjamin D. Pope, Kevin Kit Parker
  • Publication number: 20220380943
    Abstract: System, devices and methods for the fabrication of polymeric fibers, as well as resulting polymeric fibers, polymeric fiber materials and uses thereof are described. The polymeric fibers include poly(para-phenylene terephthalamide) (PPTA) fibers having an average fiber diameter in a range of 300 nm to 3 ?m, and having an average Young's modulus in a range of 1 GPa to 100 GPa. Some materials including a plurality of the polymeric fibers have a thermal conductivity (k) in a range of 0.005 W/(m·K) to 10 W/(m·K) as measured perpendicular to a plane of the material.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 1, 2022
    Inventors: Grant Michael Gonzalez, John F. Zimmerman, Kevin Kit Parker
  • Patent number: 11511129
    Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: November 29, 2022
    Assignee: President and Fellows of Harvard College
    Inventor: Kevin Kit Parker
  • Publication number: 20220248903
    Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.
    Type: Application
    Filed: February 24, 2022
    Publication date: August 11, 2022
    Inventors: Kevin Kit Parker, Alexander Peyton Nesmith, Joseph A. Festa, Michel Maalouly, Elizabeth Olayinka Ogunbiyi
  • Patent number: 11384328
    Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 12, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Alanna R. Gannon, Aaron L. Glieberman, Kevin Kit Parker, Benjamin D. Pope, Kevin L. Shores, Nina R. Sinatra
  • Publication number: 20220136136
    Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
    Type: Application
    Filed: October 14, 2021
    Publication date: May 5, 2022
    Inventors: Kevin Kit Parker, Grant Michael Gonzalez, Holly M. Golecki, Kwanwoo Shin, Josue A. Goss
  • Patent number: 11291332
    Abstract: Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: April 5, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Alexander Peyton Nesmith, Joseph A. Festa, Michel Maalouly, Elizabeth Olayinka Ogunbiyi
  • Publication number: 20220090300
    Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.
    Type: Application
    Filed: January 14, 2020
    Publication date: March 24, 2022
    Inventors: Qihan Liu, Kevin Kit Parker, Huibin Chang
  • Publication number: 20210388301
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Application
    Filed: January 11, 2021
    Publication date: December 16, 2021
    Inventors: Donald E. INGBER, Anthony BAHINSKI, Robert CUNNINGHAM, Josue A. GOSS, Geraldine A. HAMILTON, Christopher David HINOJOSA, Daniel LEVNER, Kevin Kit PARKER
  • Publication number: 20210371790
    Abstract: Systems and methods are provided including a housing configured to receive and engage a hollow tissue structure within a fluid chamber of the housing. A first pair of flow channels and a second pair of flow channels of the housing are fluidly coupled to the fluid chamber. The housing fluidly couples the first pair of flow channels and fluidly couples the second pair of flow channels via a second flow path such that a change in a fluid pressure differential between a first fluid in the first flow path and a second fluid in the second flow path deflects at least a portion of the hollow tissue structure causing a change in flow of the first fluid through the first pair of flow channels or a change in flow of the second fluid through the second pair of flow channels.
    Type: Application
    Filed: February 5, 2019
    Publication date: December 2, 2021
    Inventors: Luke A. MACQUEEN, Kevin Kit PARKER, Josue A. GOSS, Christophe CHANTRE
  • Publication number: 20210371782
    Abstract: The present invention provides methods for optically micropatterning hydrogels, which may be used for, e.g., regenerative medicine, synthetic or cultured foods, and in devices suitable for use in high throughput drug screening assays.
    Type: Application
    Filed: August 4, 2017
    Publication date: December 2, 2021
    Inventors: Kevin Kit Parker, Janna C. Nawroth, Lisa Scudder
  • Patent number: 11174571
    Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: November 16, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Grant Michael Gonzalez, Holly M. Golecki, Kwanwoo Shin, Josue A. Goss
  • Publication number: 20210324539
    Abstract: The present invention provides methods for preparing an alpha-keratin solution comprising alpha-keratin protofibrils and intermediate filaments in liquid crystal phase and uses thereof for fabricating, e.g., shape-memory polymeric fibers, yarns, threads, fabrics, structures and objects.
    Type: Application
    Filed: July 26, 2019
    Publication date: October 21, 2021
    Inventors: Luca Cera, Kevin Kit Parker
  • Publication number: 20210205076
    Abstract: The present invention provides engineered valves, tubular structures, and sheets comprising oriented polymeric fibers, e.g., nanofibers, methods of fabricating such structures, and methods of use of such structures as, for example, patches, grafts and valves, e.g., cardiac valves.
    Type: Application
    Filed: November 24, 2020
    Publication date: July 8, 2021
    Inventors: Kevin Kit Parker, Andrew K. Capulli, Josue A. Goss