Patents by Inventor Kevin M. Esvelt
Kevin M. Esvelt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230257781Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.Type: ApplicationFiled: April 6, 2023Publication date: August 17, 2023Inventors: George M. Church, Kevin M. Esvelt, Prashant G. Mali
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Patent number: 11649469Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.Type: GrantFiled: May 14, 2019Date of Patent: May 16, 2023Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Kevin M. Esvelt, Prashant G. Mali
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Publication number: 20230131972Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: ApplicationFiled: October 25, 2022Publication date: April 27, 2023Inventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Publication number: 20230039625Abstract: The invention relates, in part, to devices, systems and methods to increase the likelihood of survival and reproductive success of preselected organisms.Type: ApplicationFiled: January 13, 2021Publication date: February 9, 2023Applicant: Massachusetts Institute of TechnologyInventors: Kevin M. ESVELT, Sarah Anna VITAK
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Publication number: 20200299732Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: ApplicationFiled: April 17, 2020Publication date: September 24, 2020Inventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Patent number: 10767194Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: GrantFiled: June 14, 2019Date of Patent: September 8, 2020Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Patent number: 10752906Abstract: Stably immunized cells and methods of making stably immunized cells are provided. Methods of altering the microbiota of an ecological environment are provided. Methods of modifying target chromosomes are provided. Methods of delivering genetic material to target cells are provided.Type: GrantFiled: November 5, 2014Date of Patent: August 25, 2020Assignee: President and Fellows of Harvard CollegeInventors: Kevin M. Esvelt, Stephanie Yaung
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Patent number: 10640789Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: GrantFiled: February 22, 2016Date of Patent: May 5, 2020Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Publication number: 20200024618Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: ApplicationFiled: June 14, 2019Publication date: January 23, 2020Applicant: President and Fellows of Harvard CollegeInventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Patent number: 10526618Abstract: RNA guided Cas9 gene drives and method for their use are disclosed.Type: GrantFiled: June 3, 2016Date of Patent: January 7, 2020Assignee: President and Fellows of Harvard CollegeInventors: Kevin M. Esvelt, Andrea L. Smidler
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Publication number: 20190367948Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.Type: ApplicationFiled: May 14, 2019Publication date: December 5, 2019Inventors: George M. Church, Kevin M. Esvelt, Prashant G. Mali
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Patent number: 10329587Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.Type: GrantFiled: July 8, 2014Date of Patent: June 25, 2019Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Kevin M. Esvelt, Prashant G. Mali
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Publication number: 20190175762Abstract: Dependent gene drive systems and their use in genome editing are disclosed. Methods of making a genome editing system using dependent gene drives are also disclosed.Type: ApplicationFiled: September 28, 2016Publication date: June 13, 2019Applicant: President and Fellows of Harvard CollegeInventors: Kevin M. Esvelt, Jianghong Min
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Publication number: 20160348120Abstract: Stably immunized cells and methods of making stably immunized cells are provided. Methods of altering the microbiota of an ecological environment are provided. Methods of modifying target chromosomes are provided. Methods of delivering genetic material to target cells are provided.Type: ApplicationFiled: November 5, 2014Publication date: December 1, 2016Applicants: President and Fellows of Harvard College, President and Fellows of Harvard CollegeInventors: Kevin M. Esvelt, Stephanie Yaung
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Publication number: 20160333376Abstract: RNA guided Cas9 gene drives and method for their use are disclosed.Type: ApplicationFiled: June 3, 2016Publication date: November 17, 2016Inventors: Kevin M. Esvelt, Andrea L. Smidler
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Publication number: 20160237456Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: ApplicationFiled: February 22, 2016Publication date: August 18, 2016Inventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Publication number: 20160222416Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.Type: ApplicationFiled: July 8, 2014Publication date: August 4, 2016Inventors: George M. Church, Kevin M. Esvelt, Prashant G. Mali
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Patent number: 9267135Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: GrantFiled: June 30, 2014Date of Patent: February 23, 2016Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Prashant G. Mali, Kevin M. Esvelt
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Patent number: 9023594Abstract: The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell allows for continuous selection and mutation of the nucleic acid.Type: GrantFiled: September 8, 2009Date of Patent: May 5, 2015Assignee: President and Fellows of Harvard CollegeInventors: David R. Liu, Kevin M. Esvelt
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Publication number: 20140356959Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.Type: ApplicationFiled: June 30, 2014Publication date: December 4, 2014Inventors: George M. CHURCH, Prashant G. MALI, Kevin M. ESVELT