Abstract: A system and method for delivering irreversible electroporation treatment to a selected tissue includes introducing an endoscope into a position adjacent the selected tissue, and advancing first and second probes having electrodes at their distal ends. One probe may be inserted into the lesion or tumor and remain in place while the other probe is moved around the tumor, with activation of the electrodes occurring at each location of the probes.

Abstract: The present disclosure relates generally to positioning elongate members at a target site within a body lumen, such as for acquiring a biopsy from a peripheral airway. Some embodiments are particularly directed to an elongate member with an embedded transducer positioned at a predefined rotational angle with respect to a projected position of an instrument extended out of a distal opening of a first lumen in the elongate member. In many such embodiments, a rotational transducer may be positioned within a second lumen in the elongate member to generate a radial image including indicia of the embedded transducer. Accordingly, an operator may determine a projected position of the instrument prior to extending the instrument out of the lumen. In several embodiments, the embedded transducer may include a forward imaging transducer, such as a fiber optic.

Abstract: A device for occluding flow of materials is formed as a simple structure permitting a compact delivery configuration which may shift to an expanded deployment configuration. The device has at least one expandable portion formed of a plurality of elongated longitudinally extending frame elements. The frame elements may be spaced apart to define spaces therebetween, and a flexible occlusive material may be provided to block flow of material through such spaces. A flexible occlusive material may form one of two expandable portions of the device without the need for frame elements.

Abstract: A device includes a housing having a first opening for receiving tissue therein and a distal head disposed at least partly within the housing. The distal head is configured to rotate about a longitudinal axis of the distal head. The device also includes a first holding member coupled to the housing and a second holding member coupled to the distal head. The first and second holding members are configured so that rotating the distal head stretches a first ligation band coupled to the first and second holding members, permitting tissue drawn into the first opening to pass through an opening of the first ligation band.

Abstract: A device for treating tissue includes a capsule defining a channel extending therethrough and clip arms. Each of the arms includes a proximal part releasably coupled to a distal part, a proximal portion of the distal part configured to be received within the channel of the capsule so that the arms move proximally and distally relative to the capsule between a tissue receiving configuration, in which distal ends of the arms are separated from one another, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another. The proximal portion of each of the arms is configured to release from the corresponding distal part to lock the distal part of each of the arms over a portion of target tissue to be clipped while the proximal parts of the arms are removed from the body.

Abstract: A device for treating tissue includes a capsule defining a channel extending therethrough and clip arms. Each of the arms includes a proximal part releasably coupled to a distal part, a proximal portion of the distal part configured to be received within the channel of the capsule so that the arms move proximally and distally relative to the capsule between a tissue receiving configuration, in which distal ends of the arms are separated from one another, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another. The proximal portion of each of the arms is configured to release from the corresponding distal part to lock the distal part of each of the arms over a portion of target tissue to be clipped while the proximal parts of the alms are removed from the body.

Abstract: A device includes a housing having a first opening for receiving tissue therein and a distal head disposed at least partly within the housing. The distal head is configured to rotate about a longitudinal axis of the distal head. The device also includes a first holding member coupled to the housing and a second holding member coupled to the distal head. The first and second holding members are configured so that rotating the distal head stretches a first ligation band coupled to the first and second holding members, permitting tissue drawn into the first opening to pass through an opening of the first ligation band.

Abstract: A device for treating tissue includes a capsule defining a channel extending therethrough and clip arms. Each of the arms includes a proximal part releasably coupled to a distal part, a proximal portion of the distal part configured to be received within the channel of the capsule so that the arms move proximally and distally relative to the capsule between a tissue receiving configuration, in which distal ends of the arms are separated from one another, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another. The proximal portion of each of the aims is configured to release from the corresponding distal part to lock the distal part of each of the aims over a portion of target tissue to be clipped while the proximal parts of the alms are removed from the body.