Patents by Inventor Kevin McIntosh
Kevin McIntosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092818Abstract: The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5?-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.Type: ApplicationFiled: December 17, 2021Publication date: March 21, 2024Applicant: Merck Sharp & Dohme LLCInventors: Tamas Benkovics, Patrick S. Fier, Anna Fryszkowska, Mark A. Huffman, Tetsuji Itoh, Jongrock Kong, Peter E. Maligres, Kevin M. Maloney, John McIntosh, Grant S. Murphy, Steven M. Silverman, Hao Yang
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Patent number: 8669106Abstract: The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.Type: GrantFiled: January 9, 2009Date of Patent: March 11, 2014Assignees: Arteriocyte Inc., Universite Pierre ET Marie Curie (Paris VI)Inventors: Ramasamy Sakthivel, Donald J. Brown, Hai-Quan Mao, Luc Douay, Vincent J. Pompili, Kevin McIntosh, Hiranmoy Das, Yukang Zhao
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Patent number: 8545754Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.Type: GrantFiled: April 23, 2009Date of Patent: October 1, 2013Assignee: Medtronic, Inc.Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
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Publication number: 20130165200Abstract: Embodiments of the present invention are directed to gaming devices having a pattern display associated with game play on the gaming device, and methods of operating the gaming device to generate, modify, and interact with a pattern on the pattern display. In one instance, a method of operating a gaming device includes determining a pattern-modifying game outcome in response to a received player input, modifying a displayed pattern, and awarding a prize when the modified pattern satisfies a predetermined prize threshold.Type: ApplicationFiled: December 27, 2011Publication date: June 27, 2013Applicant: VCAT, LLCInventors: L. Donald Speer, II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Publication number: 20120231885Abstract: Embodiments of the present invention are directed to gaming devices and gaming systems having an outcome based display of summarized past gaming results and a method of processing and displaying the past gaming results. In one example, a gaming device may record game information corresponding to the gaming event on the device and a memory and store this recorded information in a memory. The recorded information may be processed by the gaming device or another device connected to the gaming device to generate a summarized display of the recorded information to depict to a current gaming player or prospective gaming player.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: VCAT, LLCInventors: L. Donald Speer II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Patent number: 8182326Abstract: Embodiments of the present invention are directed to gaming devices and gaming systems having an outcome based display of summarized past gaming results and a method of processing and displaying the past gaming results. In one example, a gaming device may record game information corresponding to the gaming event on the device and a memory and store this recorded information in a memory. The recorded information may be processed by the gaming device or another device connected to the gaming device to generate a summarized display of the recorded information to depict to a current gaming player or prospective gaming player.Type: GrantFiled: March 5, 2009Date of Patent: May 22, 2012Assignee: VCAT, LLCInventors: L. Donald Speer, II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Publication number: 20110009181Abstract: Embodiments of the present invention are directed to methods for searching for or otherwise identifying particular patterns or outcome trends associated with a gaming device, and gaming systems for implementing these methods. In one example, a gaming system may include a plurality of gaming devices having pattern displays, a server connected to the gaming devices through a network and configured to identify display information from the pattern displays of the gaming devices, and a search device operable by a player to search for desired display information and configured to identify a gaming device having pattern information displayed that substantially matches the desired display information.Type: ApplicationFiled: July 10, 2009Publication date: January 13, 2011Applicant: VCAT, LLCInventors: L. Donald Speer, II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Publication number: 20100272607Abstract: Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit, the apparatus having an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus, the apparatus comprising: a core in communication with the inlet such that blood from a patient can be supplied to the core, the core comprising a first element and a second element that interfit to define openings, wherein the elements and the openings together enhance flow of blood from the patient radially outward from the core; a heat exchanger that is arranged about the core and through which blood from the core can move radially outward; and an oxygenator that is arranged about the heat exchanger and through which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.Type: ApplicationFiled: April 23, 2009Publication date: October 28, 2010Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
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Publication number: 20100272604Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises at least one integrated pump that is provided in a core of the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the at least one integrated pump and between which blood from the at least one integrated pump can move radially outward; an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and through which blood from the heat exchanger can move radially outward; and an optional filter arranged around the oxygenator and through which blood from the oxygenator can move radially outward before exiting the apparatus through the outlet.Type: ApplicationFiled: March 4, 2010Publication date: October 28, 2010Applicant: Medtronic, Inc.Inventors: Walt L. Carpenter, Kevin McIntosh
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Publication number: 20100274170Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.Type: ApplicationFiled: April 23, 2009Publication date: October 28, 2010Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
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Publication number: 20100227662Abstract: Embodiments of the present invention are directed to gaming devices and gaming systems having an outcome based display of summarized past gaming results and a method of processing and displaying the past gaming results. In one example, a gaming device may record game information corresponding to the gaming event on the device and a memory and store this recorded information in a memory. The recorded information may be processed by the gaming device or another device connected to the gaming device to generate a summarized display of the recorded information to depict to a current gaming player or prospective gaming player.Type: ApplicationFiled: March 5, 2009Publication date: September 9, 2010Applicant: VCAT, LLCInventors: L. Donald Speer, II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Publication number: 20100227687Abstract: Embodiments of the present invention are directed to a method and system for displaying a pattern associated with a gaming device to heighten the gaming interest of players or potential players. These methods and systems include displaying an initial pattern and altering the initial pattern as play on the gaming device progresses, or as pattern modifying signals are otherwise received. The displayed pattern may be presented on any display device, including but not limited to the game screen or on any screen or panel on a gaming device, in a secondary display device attached or detached from the gaming device or table game, or any other display applications used on or with a gaming device or table.Type: ApplicationFiled: March 5, 2009Publication date: September 9, 2010Applicant: VCAT, LLCInventors: L. Donald Speer, II, W. Greg Shay, Kevin McIntosh, Donne Grable
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Publication number: 20100183561Abstract: Novel uses of Platelet Rich Plasma (PRP) for infection prevention, bone repair and transmyocardial vascularization is disclosed. The present disclosure is directed to methods for preparing concentrated mesenchymal or haematopoietic stem cells, and autologous platelet-rich plasma (PRP) from the blood utilizing the Magallen® System. The stem cells and/or PRP may be combined with secondary biological agents such as antibiotics, fibrinogen and thrombin, and appropriately used in variety of medical conditions, such as, cardiovascular, thoracic, transplantation, head and neck, oral, gastrointestinal, orthopedic, neurosurgical, and plastic surgery.Type: ApplicationFiled: July 7, 2009Publication date: July 22, 2010Applicant: ARTERIOCYTE MEDICAL SYSTEMSInventors: Ramasamy Sakthivel, Donald J. Brown, Yukang Zhao, Adam Sorkin, Vincent Pompili, Kevin Mcintosh
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Publication number: 20080044852Abstract: The present invention provides biological compositions and methods for making the same.Type: ApplicationFiled: April 26, 2007Publication date: February 21, 2008Inventors: Tessy Kanayinkal, Laura Yonce, Debra Mullins-Hirte, Trevor Huang, Rohit Cariappa, Kenneth Merte, James Keogh, Kevin McIntosh, Brian Steffens, Asha Nayak, Erick Johnson
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Publication number: 20070122393Abstract: The present invention encompasses methods and compositions for generating an isolated adipose tissue-derived stromal cell exhibiting a low level of immunogenicity. The present invention encompasses methods and compositions for reducing an immune response associated with transplantation by administering the recipient with an amount of adipose tissue-derived stromal cells effective to reduce or inhibit host rejection and/or host versus graft disease.Type: ApplicationFiled: July 14, 2006Publication date: May 31, 2007Inventors: Kevin McIntosh, James Mitchell, Jeffrey Gimble
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Publication number: 20070045201Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.Type: ApplicationFiled: September 8, 2006Publication date: March 1, 2007Inventors: Victor Dolecek, Gary Berg, Kenneth Merte, David Malcolm, Kevin McIntosh, Vitaly Sitko
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Publication number: 20060253082Abstract: Dispensing assemblies, methods, and kits of parts for dispensing two separate fluids to an treatment site, including entraining non-atomized flow of a first fluid in an atomized flow of a second fluid, delivering a first fluid upstream from a second fluid, delivering a first fluid and a second fluid with re-shapeable malleable tubes, delivering first and second fluids with releasable connectors maintained by a handle assembly, and kits of parts with angularly offset pockets.Type: ApplicationFiled: January 27, 2006Publication date: November 9, 2006Inventors: Kevin McIntosh, Victor Dolecek
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Publication number: 20060153819Abstract: The present invention encompasses methods and compositions for reducing an immune response to a transplant recipient receiving NSCs by treating said recipient with an amount of bone marrow stromal effective to reduce or inhibit host rejection of the NSCs.Type: ApplicationFiled: January 10, 2006Publication date: July 13, 2006Inventor: Kevin McIntosh
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Publication number: 20060124561Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.Type: ApplicationFiled: November 10, 2005Publication date: June 15, 2006Inventors: Victor Dolecek, Gary Berg, Kenneth Merte, David Malcolm, Kevin McIntosh, Vitaly Sitko
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Publication number: 20060057125Abstract: The present invention encompasses methods and compositions for reducing an immune response to a transplant in a recipient by treating said recipient with an amount of liver stromal cells effective to reduce or inhibit host rejection of the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with liver stromal cells.Type: ApplicationFiled: September 8, 2005Publication date: March 16, 2006Inventor: Kevin McIntosh