Patents by Inventor Kim D. Vandegriff

Kim D. Vandegriff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyalkylene oxide valerate hemoglobin conjugates
    Patent number: 10821158
    Abstract: The present invention relates generally to polyethylene glycol (PEG) conjugated hemoglobins made by conjugation of succinimidyl-valerate activated polyethylene glycol to primary amines and N-terminal valines of the hemoglobin.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: November 3, 2020
    Inventors: Ashok Malavalli, Gnel Mkrtchyan, Kim D. Vandegriff
  • Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
    Patent number: 9493616
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: November 15, 2016
    Assignee: Sangart, Inc.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • POLYALKYLENE OXIDE VALERATE HEMOGLOBIN CONJUGATES
    Publication number: 20160022783
    Abstract: The present invention relates generally to polyethylene glycol (PEG) conjugated hemoglobins made by conjugation of succinimidyl-valerate activated polyethylene glycol to primary amines and N-terminal valines of the hemoglobin.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Ashok Malavalli, Gnel Mkrtchyan, Kim D. Vandegriff
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 9241979
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: January 26, 2016
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS
    Publication number: 20150094267
    Abstract: The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO), for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins and methods for the use of nitroxylated proteins in the treatment of various conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Gnel Mkrtchyan
  • DIASPIRIN CROSSLINKED PEGYLATED HEMOGLOBIN
    Publication number: 20150087590
    Abstract: PEGylated diaspirin-crosslinked hemoglobin conjugates having high oxygen affinity are described which have enhanced nitrite reductase activity to deliver oxygen, carbon monoxide, nitric oxide or mixtures thereof to tissues to treat various diseases and conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 26, 2015
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
  • Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
    Patent number: 8609815
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: December 17, 2013
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20130288949
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: June 21, 2013
    Publication date: October 31, 2013
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR PREPARING PEG-HEMOGLOBIN CONJUGATES USING REDUCED REACTANT RATIOS
    Publication number: 20130217860
    Abstract: The present invention relates generally to methods for preparing polyethylene glycol (“PEG”) conjugated hemoglobin (“Hb”) using reduced reactant ratios. More specifically, the present invention relates to methods for preparing PEG conjugated Hb (“PEG-Hb”) with enhanced yield and purity.
    Type: Application
    Filed: February 23, 2011
    Publication date: August 22, 2013
    Applicant: SANGART, INC.
    Inventors: Ashok Malavalli, Kim D. Vandegriff
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 8377868
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: February 19, 2013
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHOD OF DELIVERING OXYGEN USING PEG-HEMOGLOBIN CONJUGATES WITH ENHANCED NITRITE REDUCTASE ACTIVITY
    Publication number: 20120282236
    Abstract: The present invention relates generally to methods for delivering oxygen to tissue and reducing nitrite to nitric oxide in the microvasculature. Specifically, the present invention is directed towards using a deoxygenated pegylated hemoglobin conjugate having enhanced nitrite reductase activity to deliver oxygen to tissues.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 8, 2012
    Applicant: SANGART, INC.
    Inventors: Kim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
  • Method to enhance hemodynamic stability using oxygen carrying compositions
    Patent number: 8278275
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: October 2, 2012
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR PRESERVING AN ORGAN FOR TRANSPLANTATION USING A HEMOGLOBIN-CARBON MONOXIDE COMPLEX
    Publication number: 20120196270
    Abstract: The present invention relates generally to methods of preserving an organ for transplantation. Specifically, the present invention is directed towards treating an organ with a hemoglobin-carbon monoxide complex to preserve the organ before transplantation.
    Type: Application
    Filed: February 1, 2012
    Publication date: August 2, 2012
    Applicant: Sangart, Inc.
    Inventors: Mark YOUNG, Kim D. VANDEGRIFF
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Nitric Oxide (NO) to Cells
    Publication number: 20120094936
    Abstract: The present invention relates to compositions for delivering nitric oxide (NO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver NO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. Winslow, Nancy Jo Winslow, Kim D. Vandegriff
  • METHODS FOR PREPARING STABLE DEOXYGENATED PEG-HEMOGLOBIN CONJUGATE SOLUTIONS COMPRISING AN ANTIOXIDANT
    Publication number: 20120059153
    Abstract: The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.
    Type: Application
    Filed: September 1, 2011
    Publication date: March 8, 2012
    Applicant: Sangart, Inc.
    Inventors: Kim D. VANDEGRIFF, Ashok S. Malavalli
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20120004396
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 5, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • Method for making polyalkylene oxide modified hemoglobin
    Patent number: 8021858
    Abstract: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently bound to a deoxygenated hemoglobin and a p50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 20, 2011
    Assignee: Sangart, Inc.
    Inventors: Kim D. Vandegriff, Ashok S. Malavalli, Gnel M. Mkrtchyan
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 7989414
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 2, 2011
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR MAKING HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN FOR OXYGEN TRANSPORT
    Publication number: 20100105606
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 29, 2010
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • METHOD TO ENHANCE HEMODYNAMIC STABILITY USING OXYGEN CARRYING COMPOSITIONS
    Publication number: 20100087361
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Application
    Filed: November 23, 2009
    Publication date: April 8, 2010
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff