Patents by Inventor Kimihisa Ueno

Kimihisa Ueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9643952
    Abstract: The invention provides a pyridone compound represented by the following formula (I) [wherein, R1 represents cycloalkyl optionally having substituent(s) and the like, R2 represents a hydrogen atom and the like, R3 represents hydroxy and the like, and R4A represents the following formula (R4A-1) (wherein, R4 and R5 are the same or different and each represents a hydrogen atom and the like), and the like], or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases, and the like.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: May 9, 2017
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Rina Nakamura, Seiji Aratake, Kenji Uchida, Kimihisa Ueno, Maasa Motosawa, Takahiro Kabeya
  • Patent number: 9475805
    Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: October 25, 2016
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
  • Publication number: 20150315172
    Abstract: The invention provides a pyridone compound represented by the following formula (I) [wherein, R1 represents cycloalkyl optionally having substituent(s) and the like, R2 represents a hydrogen atom and the like, R3 represents hydroxy and the like, and R4A represents the following formula (R4A-1) (wherein, R4 and R5 are the same or different and each represents a hydrogen atom and the like), and the like], or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases, and the like.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 5, 2015
    Inventors: Rina NAKAMURA, Seiji ARATAKE, Kenji UCHIDA, Kimihisa UENO, Maasa MOTOSAWA, Takahiro KABEYA
  • Publication number: 20150291587
    Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
    Type: Application
    Filed: May 26, 2015
    Publication date: October 15, 2015
    Inventors: Arata YANAGISAWA, Keiji UEHARA, Masahiro MATSUBARA, Kimihisa UENO, Michihiko SUZUKI, Takeshi KUBOYAMA, Keisuke YAMAMOTO, Tomohiro TAMURA
  • Patent number: 8969345
    Abstract: A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPAR? agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: March 3, 2015
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Keisuke Yamamoto, Tomohiro Tamura, Rina Nakamura, Kimihisa Ueno, Shintaro Hosoe
  • Publication number: 20140163008
    Abstract: A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPAR? agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.
    Type: Application
    Filed: August 3, 2011
    Publication date: June 12, 2014
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Keisuke Yamamoto, Tomohiro Tamura, Rina Nakamura, Kimihisa Ueno, Shintaro Hosoe
  • Patent number: 8729264
    Abstract: Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 20, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Daisuke Nakashima, Kimihisa Ueno, Mirai Mizutani, Daisuke Harada, Katsuya Kobayashi, Kazuki Hemmi
  • Publication number: 20130267711
    Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
    Type: Application
    Filed: June 3, 2013
    Publication date: October 10, 2013
    Inventors: Arata YANAGISAWA, Keiji UEHARA, Masahiro MATSUBARA, Kimihisa UENO, Michihiko SUZUKI, Takeshi KUBOYAMA, Keisuke YAMAMOTO, Tomohiro TAMURA
  • Patent number: 8486980
    Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: July 16, 2013
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
  • Patent number: 8242151
    Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: August 14, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
  • Publication number: 20110201640
    Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
    Type: Application
    Filed: August 6, 2009
    Publication date: August 18, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
  • Publication number: 20100256134
    Abstract: Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
    Type: Application
    Filed: September 26, 2008
    Publication date: October 7, 2010
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Daisuke Nakashima, Kimihisa Ueno, Mirai Mizutani, Daisuke Harada, Katsuya Kobayashi, Kazuki Hemmi
  • Publication number: 20090176760
    Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
    Type: Application
    Filed: February 7, 2008
    Publication date: July 9, 2009
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
  • Patent number: 7524852
    Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: April 28, 2009
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hitoshi Arai, Tsutomu Matsumura, Hiroshi Ishida, Yosuke Yamaura, Seiji Aratake, Etsuo Ohshima, Koji Yanagawa, Motoki Miyama, Koji Suzuki, Ari Kawabe, Satoshi Nakanishi, Katsuya Kobayashi, Takashi Sato, Ichiro Miki, Kimihisa Ueno, Shinya Fujii, Miho Iwase
  • Publication number: 20070191402
    Abstract: The present invention provides a screening method of a substance which inhibits binding of a condensed purine derivative to a pancreatic ? cell or a treated product of the cell, a substance which inhibits binding of a condensed purine derivative to a protein capable of the condensed purine derivative, and a substance which inhibits the expression or enzymatic activity of a protein capable of a condensed purine derivative, which comprises using the condensed purine derivative and a pancreatic ? cell or a treated product of the cell or a protein capable of binding to the condensed purine derivative.
    Type: Application
    Filed: May 16, 2003
    Publication date: August 16, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Hiroki Ishiguro, Yuko Saeki, Seiji Sugimoto, Masahiro Matsubara, Kimihisa Ueno, Kiyotoshi Mori, Satoshi Nakanishi, Hiroshi Yano
  • Publication number: 20070037834
    Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.
    Type: Application
    Filed: June 6, 2003
    Publication date: February 15, 2007
    Inventors: Hitoshi Arai, Tsutomu Matsumura, Hiroshi Ishida, Yosuke Yamaura, Seiji Aratake, Etsuo Ohshima, Koji Yanagawa, Motoki Miyama, Koji Suzuki, Ari Kawabe, Satoshi Nakanishi, Katsuya Kobayashi, Takashi Sato, Ichiro Miki, Kimihisa Ueno, Shinya Fujii, Miho Iwase
  • Publication number: 20060252780
    Abstract: A fused pyrimidine derivative is presented. The derivatie has an insulin secretion stimulating activity represented by Formula (I): {wherein R1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X1 and X2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II): represents formula (III): [wherein X—Y—Z represents R2C?CR3—NR4 (wherein R2, R3 and R4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 23, 2004
    Publication date: November 9, 2006
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Takao Nakajima, Kimihisa Ueno, Yuji Nomoto, Yuichi Matsumoto, Hiroshi Yano, Satoshi Nakanishi, Kotaro Takasaki, Hideaki Kusaka
  • Patent number: 7005430
    Abstract: A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C?O or N?C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C?O and R2 represents a substituted lower
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 28, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kimihisa Ueno, Akira Ogawa, Yoshihisa Ohta, Yuji Nomoto, Kotaro Takasaki, Hideaki Kusaka, Hiroshi Yano, Chiharu Nakagawa, Satoshi Nakanishi
  • Publication number: 20040180925
    Abstract: A compound represented by general formula (I):
    Type: Application
    Filed: November 10, 2003
    Publication date: September 16, 2004
    Inventors: Kenji Matsuno, Kimihisa Ueno, Yasuhiro Iwata, Yuichi Matsumoto, Satoshi Nakanishi, Kotaro Tasaki, Hideaki Kusaka, Yuji Nomoto, Akira Ogawa
  • Publication number: 20030176698
    Abstract: A condensed purine derivative represented by Formula (I): 1
    Type: Application
    Filed: October 22, 2002
    Publication date: September 18, 2003
    Inventors: Kimihisa Ueno, Akira Ogawa, Yoshihisa Ohta, Yuji Nomoto, Kotaro Takasaki, Hideaki Kusaka, Hiroshi Yano, Chiharu Nakagawa, Satoshi Nakanishi