Patents by Inventor Kirsty A. McFarland

Kirsty A. McFarland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210293707
    Abstract: A well reader and actuator (100) for a well array (50) has an array of detectors, each detector for detecting a fluorescence signal from fluorophores in a respective well of the well array and an excitation subsystem for exciting the fluorophores in the wells of the well array. Embodiments of this invention can be used to carry out two important functions in a highly parallel manner: by addressing individual wells in a 32, 96, 384 etc. well array, where each well contains a potential chemical or biological reaction. The two functions are: 1) through thermal, optical or other means and combinations thereof the rate of a chemical or biological reaction is controlled or gated (e.g. colder wells inhibit a reaction, or an enzymatic reaction requires blue light to proceed); and 2) through use of fluorescent species that are sensitive to the target reaction—or reactions—an optical readout of fluorescent intensity and/or lifetime is tracked to monitor the evolution of the reaction.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 23, 2021
    Inventors: Ian W. Frank, Andrew P. Magyar, Cory Larsen, Jonathan S. Ung, Kasey J. Russell, Kirsty A. McFarland, Jeffrey A. Korn
  • Publication number: 20210220823
    Abstract: Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 22, 2021
    Inventors: Kirsty A. McFarland, Charles A. Lissandrello, Andrew P. Magyar, Erin Rosenberger
  • Publication number: 20210198726
    Abstract: Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 1, 2021
    Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ting Pang, Michael Springer
  • Publication number: 20200363398
    Abstract: A method for identifying an interaction between a pathogen and a biological agent includes providing a platform for supporting cell growth, seeding different interaction sites on the platform with different biological agents, perfusing the platform with a fluid that carries substances for promoting growth and maintenance of the cells, exposing all of the interaction sites to a solution containing viruses, and detecting evidence indicative of the interaction, the evidence comprising evidence indicative of a change in structure or composition of a medium at the interaction site. The biological agent includes cells alone or cells with another substance.
    Type: Application
    Filed: January 9, 2019
    Publication date: November 19, 2020
    Inventors: Else M. Vedula, Kirsty A. McFarland, Amanda Nicole Billings-Siuti, Andrew P. Magyar
  • Publication number: 20200263152
    Abstract: Described herein are genetically engineered template-independent DNA polymerases, specifically terminal deoxynucleotidyl transferases, and methods of using these polymerases to control DNA synthesis by adding a single nucleotide (mononucleotide) at a time to the 3? end of a growing single-stranded DNA polynucleotide.
    Type: Application
    Filed: May 22, 2018
    Publication date: August 20, 2020
    Inventors: Andrew P. Magyar, Peter Cavanagh, Miles Rogers, Kirsty A. McFarland, Melissa M. Sprachman, Amanda Nicole Billings-Siuti, Nicole E. Raustad
  • Publication number: 20190354871
    Abstract: A parallelized chain-synthesizing technique includes capillary tubes, where each tube provides multiple locations or addresses where a specific arbitrary sequence for polymeric chains can be synthesized. An optical addressing system selectively delivers light to the locations to mediate or control reactions in the tubes.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 21, 2019
    Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ian Ward Frank, Kenneth T. Kotz, Stacey Markovic, Haiyao Huang, Steven J. Byrnes, Gregg E. Favalora, Melissa M. Sprachman, Ryan A. Dubay, Emma Vargo, Peter Cavanagh, Erin Rosenberger
  • Patent number: 10260083
    Abstract: The present disclosure provides compositions including recombinant K or 812 bacteriophages, methods for making the same, and uses thereof. The recombinant K or 812 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: April 16, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Peter Cavanagh, Helen Bartlett, Kirsty A. McFarland, Nicole E. Raustad, Sarah Gruszka, Jason Holder
  • Publication number: 20190048325
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes via semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 14, 2019
    Inventors: Kirsty A. McFarland, Miles T. Rogers, Connor McBrine, Jason W. Holder