Patents by Inventor Kiyohiko Hatake

Kiyohiko Hatake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190078153
    Abstract: A method of analyzing eukaryotic cells includes conducting a reaction using an antibody against a surface antigen of a cell to be analyzed for genetic abnormality or a cell not to be analyzed for the abnormality, to distinguish cells to be analyzed for the abnormality, subjecting the cells to permeation treatment, and to immobilization treatment after at least one of the antigen-antibody reaction and permeation treatment steps, conducting fluorescence in situ hybridization using at least one nucleic acid probe, each probe having a different fluorescent label and specifically binding to a genetic sequence to be detected, obtaining fluorescence signals from the probes in the cells using a three-dimensional image analysis method, and determining whether any cells have the abnormality by analyzing the cells distinguished to be analyzed for the abnormality, at least one signal count of the fluorescence signals, the signal count corresponding respectively to the probe.
    Type: Application
    Filed: November 7, 2018
    Publication date: March 14, 2019
    Applicants: OLYMPUS CORPORATION, JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Yuji MISHIMA, Kiyohiko HATAKE, Takashi ABE
  • Publication number: 20120115146
    Abstract: The present invention relates to a method for analyzing genetically abnormal cells including (a) preparing a cell sample containing eukaryotic cells, (b) conducting an antigen-antibody reaction to cells contained in the cell sample using antibodies which specifically bind to a molecule existing on the cell surface of eukaryotic cells after (a), (c) subjecting the cells contained in the cell sample to a permeation treatment after (b), (d) subjecting the cells contained in the cell sample to an immobilization treatment after (b), (e) conducting FISH to the cells contained in the cell sample using nucleic acid probes after (d), (f) analyzing fluorescence signals from the nucleic acid probes in the cells contained in the cell sample using a three-dimensional image analysis method after (e), and (g) determining whether the cells contained in the cell sample are genetically abnormal cells or not based on the results of (b) and (f).
    Type: Application
    Filed: November 7, 2011
    Publication date: May 10, 2012
    Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH, OLYMPUS CORPORATION
    Inventors: Yuji MISHIMA, Kiyohiko Hatake, Takashi Abe
  • Patent number: 7419667
    Abstract: A lactoferrin hydrolysate mixture or lactoferrin partial peptide that can be obtained by hydrolyzing lactoferrin with a hydrolytic enzyme and has an action of enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer is used as an active ingredient of a drug for enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: September 2, 2008
    Assignee: Morinaga Milk Industry Co. Ltd.
    Inventors: Kiyohiko Hatake, Yasuhito Terui, Yuji Mishima, Akio Yamada, Takuma Sakurai, Takehito Itoh
  • Publication number: 20060204501
    Abstract: A lactoferrin hydrolysate mixture or lactoferrin partial peptide that can be obtained by hydrolyzing lactoferrin with a hydrolytic enzyme and has an action of enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer is used as an active ingredient of a drug for enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer.
    Type: Application
    Filed: March 9, 2005
    Publication date: September 14, 2006
    Inventors: Kiyohiko Hatake, Yasuhito Terui, Yuji Mishima, Akio Yamada, Takuma Sakurai, Takehito Itoh