Abstract: Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N?CZ2—, —CY2?CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.

Abstract: A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that anon-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being an adenovirus which is used as a vector and engineered by incorporating thereto a detectable reporter gene and at least 3 human PXR binding regions falling within an untranslated region of a human CYP3A gene, and virus (B) being an adenovirus which is used as a vector and engineered by incorporating thereto a human PXR cDNA; and subsequently expression level of the reporter gene is determined in the non-human animal or the cultured human cells.

Abstract: A fluid fuel pump and its electrically driven brushless motor are located at opposite ends of a common housing.

Abstract: A motor driving apparatus has a loss-of-synchronism monitoring circuit that monitors the rotation of a rotary machine such as a brushless DC motor to detect a sign of transition to a state of loss of synchronism. When the sign is detected, an energization control circuit temporarily stops driving of the rotary machine to bring it into a free running state, and thereafter carries out control so as to resume driving of the rotary machine. Further, the motor driving apparatus has an inverter and a drive control circuit that controls switching operation of the inverter based on rotation of the rotary machine.

Abstract: A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3? end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that the expression of a reporter molecule is increased by the drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 in the reporter system using the reporter vector.

Abstract: A motor driving apparatus has a loss-of-synchronism monitoring circuit that monitors the rotation of a rotary machine such as a brushless DC motor to detect a sign of transition to a state of loss of synchronism. When the sign is detected, an energization control circuit temporarily stops driving of the rotary machine to bring it into a free running state, and thereafter carries out control so as to resume driving of the rotary machine. Further, the motor driving apparatus has an inverter and a drive control circuit that controls switching operation of the inverter based on rotation of the rotary machine.

Abstract: An integrated value of discharge quantity of a fuel pump is used as a parameter evaluating a pressure loss of a fuel filter. A target discharge quantity is obtained by correcting a fuel quantity required by an engine with a filter pressure loss correction amount corresponding to an integrated value of the discharged quantity. A target rotational speed of the fuel pump is computed based on the target discharge quantity, so that the target rotational speed is corrected in accordance with the pressure loss of the fuel filter. Alternatively, the target rotational speed may be corrected in accordance with a deterioration degree of the fuel pump.

Abstract: A fuel pump control device is for a fuel supply system for an engine. The system includes a fuel tank, a subtank, a fuel pump pumping fuel in the subtank for supply to the engine, a pressure regulator regulating fuel pressure from the fuel pump within a set pressure, and a jet pump pumping fuel in the fuel tank into the subtank through pumping action by a fuel ejection flow to the fuel tank through a return pipe of the regulator. The device includes a fuel level detecting unit for detecting fuel tank level and a control unit for controlling fuel discharge amount from the fuel pump. The control unit sets jet pump drive correction amount of fuel for driving the jet pump based on the fuel tank level. The control unit increases the fuel discharge amount from the fuel pump by the correction amount to drive the jet pump.

Abstract: An X-ray computed tomography apparatus includes an X-ray source, a high voltage generating unit, an X-ray detector detecting X-rays transmitted through a subject to generate projection data, a storage unit storing the projection data in association with electrocardiographic data of the subject, a setting unit setting a specific cardiac phase in accordance with an operator's instruction, a reconstruction unit reconstructing a tomogram based on projection data sets acquired in specific periods centered on the specific cardiac phase throughout cardiac cycles, a period extending unit extending the specific period on the basis of a heart rate fluctuation range of the subject, and a control unit controlling the high voltage generating unit to generate a relatively high dose of X-rays in the extended specific period and generate a relatively low dose of X-rays in a period other than the extended specific period.

Abstract: An electric fuel pump is disclosed which includes a pump portion, a motor portion, a housing, and a fuel passage. The pump portion pressurizes fuel. The motor portion drives the pump portion. The motor portion includes a rotor with a rotating shaft and a stator that surrounds an outer periphery of the rotor. The housing surrounds, at least, an outer periphery of the stator of the motor portion. The fuel passage, through which the fuel pressurized by the pump portion passes the motor portion, is made up of a clearance between the outer periphery of the stator of the motor portion and an inner periphery of the housing. The clearance extends, at least, in the axial direction of the rotating shaft of the rotor of the motor portion.

Abstract: A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3? end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that the expression of a reporter molecule is increased by the drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 in the reporter system using the reporter vector.

Abstract: An apparatus for estimating rotor position for brushless motors capable of accurately estimating rotor position even though power source voltage fluctuates is provided. First, the power source voltage is detected, and voltage is supplied only for a certain period of time and a current response is detected. The current detection value is multiplied by the ratio of a reference voltage to the power source voltage detected to correct the current detection value. Specifically, the peak current detection value is corrected upwardly or downwardly in each direction. A voltage supplying direction in which the current detection value is maximized is searched for to estimate the rotor position and a brushless motor is started.

Abstract: An apparatus for estimating rotor position for brushless motors capable of accurately estimating rotor position is provided. The apparatus may be used as a start-up system for brushless motors. The apparatus performs accurate estimation even though power source voltage fluctuates, and is able to provide compact configuration. The apparatus supplies voltage to the coils respectively. In each supplying period, the apparatus counts voltage supply period of time until current value reaches to a current threshold value. Since a coil indicative of rotor stop position is prone to be magnetically saturated. The apparatus estimates the rotor stop position based on the voltage supply periods. Then, the apparatus starts a switching sequence based on the rotor stop position.

Abstract: Division members (31, 32) separately molded to form a hollow component are brought into contact with each other and are arranged in dies (14, 24). The peripheral edge of the contact parts is formed with a peripheral edge path (330) to be filled with a molten resin. In the peripheral edge path (330), protrusions (316, 326) are projected from the division members (31, 32) continuously over the whole periphery of the peripheral edge path (330). The molten resin is filled in the peripheral edge path 330, and is welded with the protrusions (316, 326). As a result, a weld structure is obtained in which portions having a high welding strength are continuously formed over the whole periphery of the peripheral edge path (330).

Abstract: A stator of an electric motor includes coil cores, bobbins and coils. The coil cores include six coil cores, which are arranged at equal angular intervals in a circumferential direction. The bobbins respectively cover outer peripheral surfaces of the coil cores, and the coils are respectively wound around outer peripheral surfaces of the bobbins. Among the six coils, each diametrically opposed two coils are electrically connected to each other through the corresponding connection line. Positioning members displace positions of the connection lines from one another, so that interference between the connection lines and interference between the connection line and the coils are limited.

Abstract: A control system controls a multiphase rotating machine by a 120° energization process and a PWM process. In the 120° energization process, respective ones of switching elements of a high side arm and switching elements of a low side arm of a power conversion circuit are turned on. In the PWM process, the switching elements of the power conversion circuit turn on/off so that two phases that are connected to the switching elements that are in the on-state are alternately rendered conductive to the high potential side input terminal and the low potential side input terminal of the power conversion circuit.

Abstract: The outer periphery of a disc-shaped impeller is surrounded with an annular portion. Vane grooves are formed on the inner circumferential side of the annular portion on both sides in the axial direction. The vane grooves, which are adjacent to each other, are partitioned with a partition wall that is bent at the substantially center in the axial direction. The partition wall is bent to the rear side relative to the rotative direction. The vane grooves, which are formed on both sides in the axial direction, are partitioned with a wall from each other partially on the radially inner side thereof. A partition wall, which is arranged on the rear side of the vane groove relative to the rotative direction, has a fore face that is on the fore side of the partition wall relative to the rotative direction. The fore face is an inclined flat face that is inclined to the rear side relative to the rotative direction, as extending to the radially outer side.

Abstract: Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N?CZ2-, —CY2?CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.

Abstract: A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that a non-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being an adenovirus which is used as a vector and engineered by incorporating thereto a detectable reporter gene and at least 3 human PXR binding regions falling within an untranslated region of a human CYP3A gene, and virus (B) being an adenovirus which is used as a vector and engineered by incorporating thereto a human PXR cDNA; and subsequently expression level of the reporter gene is determined in the non-human animal or the cultured human cells.

Abstract: A motor driving apparatus has a loss-of-synchronism monitoring circuit that monitors the rotation of a rotary machine such as a brushless DC motor to detect a sign of transition to a state of loss of synchronism. When the sign is detected, an energization control circuit temporarily stops driving of the rotary machine to bring it into a free running state, and thereafter carries out control so as to resume driving of the rotary machine. Further, the motor driving apparatus has an inverter and a drive control circuit that controls switching operation of the inverter based on rotation of the rotary machine.