Patents by Inventor Kiyoshi Nakayama

Kiyoshi Nakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10933065
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: March 2, 2021
    Assignee: ArQule Inc.
    Inventors: Jean-Marc Lapierre, Sudharshan Eathiraj, Nivedita Namdev, Brian Schwartz, Yusuke Ota, Takayuki Momose, Tomoyuki Tsunemi, Hiroaki Inagaki, Kiyoshi Nakayama
  • Patent number: 10875083
    Abstract: A forged crankshaft manufacturing apparatus processes a forged blank with no flash. The forged blank includes at least one rough crank arm having an excess portion protruding from an outer periphery of a side portion thereof. The manufacturing apparatus includes a first die and a second die paired with each other, a retaining device, and a moving device. The first die and the second die bend or crash the excess portion. The retaining device retains at least one of the rough journals or at least one of the rough pins such that a rough pin decentering direction is perpendicular to a reducing direction in which the first die and the second die apply force for reduction. The moving device supports the retaining device such that the retaining device is movable in the reducing direction.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: December 29, 2020
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Tomohisa Yamashita, Kunihiro Yabuno, Ken Yoshino, Sho Takamoto, Hiroyuki Kurokawa, Kenji Tamura, Junichi Okubo, Kiyoshi Nakayama, Toru Horiuchi
  • Patent number: 10851092
    Abstract: The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) as defined herein: (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: December 1, 2020
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hiroaki Inagaki, Yoshihiro Shibata, Hidenori Namiki, Hideaki Kageji, Kiyoshi Nakayama, Yasuyuki Kaneta
  • Publication number: 20200176774
    Abstract: Provided is a magnesium secondary battery including a positive electrode member 23 including at least a positive electrode active material layer 23B, a separator 24 disposed facing the positive electrode member 23, a negative electrode member 25 containing magnesium or a magnesium compound disposed facing the separator 24, and an electrolytic solution containing a magnesium salt. The positive electrode active material layer 23B includes magnesium sulfide having a zinc blende type crystal structure.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 4, 2020
    Inventors: Kazuhiro KAMIGUCHI, Ryuhei MATSUMOTO, Kiyoshi KUMAGAE, Shizuka HOSOI, Yuri NAKAYAMA
  • Patent number: 10673241
    Abstract: Systems and methods for controlling battery charge levels to maximize savings in a behind the meter energy management system include predicting a demand charge threshold with a power demand management controller based on historical load. A net energy demand is predicted for a current day with a short-term forecaster. A demand threshold maximizes financial savings using the net energy demand using a rolling time horizon optimizer by concurrently optimizing the demand charge savings and demand response rewards. A load reduction capability factor of batteries is determined with a real-time controller corresponding to an amount of energy to fulfill the demand response rewards. The net energy demand is compared with the demand threshold to determine a demand difference. Battery charge levels of the one or more batteries are controlled with the real time controller according to the demand difference and the load reduction capability factor.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: June 2, 2020
    Assignee: NEC Corporation
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma, Ali Hooshmand
  • Patent number: 10673242
    Abstract: Systems and methods for controlling battery charge levels to maximize savings in a behind the meter energy management system include predicting a demand charge threshold with a power demand management controller based on historical load. A net energy demand is predicted for a current day with a short-term forecaster. A demand threshold maximizes financial savings using the net energy demand using a rolling time horizon optimizer by concurrently optimizing the demand charge savings and demand response rewards. A load reduction capability factor of batteries is determined with a real-time controller corresponding to an amount of energy to fulfill the demand response rewards. The net energy demand is compared with the demand threshold to determine a demand difference. Battery charge levels of the one or more batteries are controlled with the real time controller according to the demand difference and the load reduction capability factor.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: June 2, 2020
    Assignee: NEC Corporation
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma, Ali Hooshmand
  • Patent number: 10626810
    Abstract: A control apparatus for a diesel engine includes a neighboring temperature estimating section which estimates a temperature of a neighborhood of a glow plug that heats an interior of a cylinder upon startup, and a supercharging pressure control section which controls a supercharging pressure in such a way that a rotation fluctuation of the engine does not increase, on the basis of the estimated temperature of the neighborhood of the glow plug.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: April 21, 2020
    Assignee: NISSAN MOTOR CO., LTD.
    Inventors: Toru Nishizawa, Shuichi Iio, Kiyoshi Ohga, Ryota Nakayama, Takashi Yamazaki, Yoshihiro Imaoka, Yasushi Ohmura, Isshou Uehara, Masahiko Nakano, Manabu Hasegawa
  • Patent number: 10585123
    Abstract: A computer-implemented method, system, and computer program product are provided for anomaly detection in a power system. The method includes receiving, by a processor-device, a plurality of measurements from a plurality of meters throughout the power system. The method also includes generating, by the processor-device, temporal causal networks based on pair-wise relationships between the plurality of measurements from the plurality of meters over time. The method additionally includes determining, by the processor-device, invariant relationships for the plurality of meters between the temporal causal networks. The method further includes predicting, by the processor-device, an anomaly from the invariant relationships for the plurality of meters with a residual anomaly threshold. The method also includes disabling one of the plurality of meters that originated the anomaly.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: March 10, 2020
    Assignee: NEC Corporation
    Inventors: Kiyoshi Nakayama, Chenrui Jin, Ratnesh Sharma, Nikhil Muralidhar
  • Publication number: 20200061071
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Inventors: Jean-Marc LAPIERRE, Sudharshan EATHIRAJ, Nivedita NAMDEV, Brian SCHWARTZ, Yusuke OTA, Takayuki MOMOSE, Tomoyuki TSUNEMI, Hiroaki INAGAKI, Kiyoshi NAKAYAMA
  • Publication number: 20200039974
    Abstract: The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) as defined herein: (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 6, 2020
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Hiroaki Inagaki, Yoshihiro Shibata, Hidenori Namiki, Hideaki Kageji, Kiyoshi Nakayama, Yasuyuki Kaneta
  • Publication number: 20190358233
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Craig BATES, Sudharshan Eathiraj, Hiroaki Inagaki, Jean-Marc Lapierre, Takayuki Momose, Kiyoshi Nakayama, Takashi Odagiri, Masahiro Ota, Yusuke Ota, Yoshihiro Shibata, Manish Tandon, Tomoyuki Tsunemi
  • Publication number: 20190288513
    Abstract: A system and methods are provided for a decentralized transactive energy management. The method includes calculating, by a processor-device, power balancing at one of a plurality of nodes responsive to current statistics at the one of a plurality of nodes. The method also includes estimating, by the processor-device, a present energy demand for the one of a plurality of nodes responsive to the current statistics. The method additionally includes obtaining, by the processor-device, an amount of excess energy available another of the plurality of nodes. The method further includes optimizing, by the processor-device, a power flow between the one of the plurality of nodes and the another of the plurality of nodes to satisfy the present energy demand for the one of the plurality of nodes. The method also includes transferring the excess energy from the another of the plurality of nodes to the one of the plurality of nodes.
    Type: Application
    Filed: January 25, 2019
    Publication date: September 19, 2019
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma
  • Publication number: 20190192520
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Jean-Marc LAPIERRE, Sudharshan EATHIRAJ, Nivedita NAMDEV, Brian SCHWARTZ, Yusuke OTA, Takayuki MOMOSE, Tomoyuki TSUNEMI, Hiroaki INAGAKI, Kiyoshi NAKAYAMA
  • Publication number: 20190170376
    Abstract: [Problem to be Solved] To provide a gas humidity regulating method and a regulator that can regulate a temperature during humidity control and improve humidity-control efficiency. In an air humidity regulating method for gas subjected to treatment, a first medium 22 is caused to flow onto a heat exchanging pipe 17 of a gas-liquid contact part 18 in a dehumidifier 11; meanwhile, a second medium 24 is passed through the heat exchanging pipe 17. In this state, air is fed into a gas-liquid contact case 13 from an inlet port 14 and gas-liquid contact is made by the first medium 22 on the gas-liquid contact part 18 so as to absorb water content from the air into the first medium 22. The first medium 22 contains an ionic liquid having high absorbency. The temperature of the first medium 22 is regulated by the second medium 24. After that, treated air is discharged from an outlet port 15 of the gas-liquid contact case 13.
    Type: Application
    Filed: October 4, 2017
    Publication date: June 6, 2019
    Inventors: Xinming WANG, Hiroshi NAKAYAMA, Kiyoshi SAITO, Seiichi YAMAGUCHI, Olivier ZEHNACKER, Yoichi MIYAOKA
  • Publication number: 20190148945
    Abstract: Systems and methods for controlling battery charge levels to maximize savings in a behind the meter energy management system include predicting a demand charge threshold with a power demand management controller based on historical load. A net energy demand is predicted for a current day with a short-term forecaster. A demand threshold maximizes financial savings using the net energy demand using a rolling time horizon optimizer by concurrently optimizing the demand charge savings and demand response rewards. A load reduction capability factor of batteries is determined with a real-time controller corresponding to an amount of energy to fulfill the demand response rewards. The net energy demand is compared with the demand threshold to determine a demand difference. Battery charge levels of the one or more batteries are controlled with the real time controller according to the demand difference and the load reduction capability factor.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 16, 2019
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma, Ali Hooshmand
  • Publication number: 20190147552
    Abstract: Systems and methods for controlling battery charge levels to maximize savings in a behind the meter energy management system include predicting a demand charge threshold with a power demand management controller based on historical load. A net energy demand is predicted for a current day with a short-term forecaster. A demand threshold maximizes financial savings using the net energy demand using a rolling time horizon optimizer by concurrently optimizing the demand charge savings and demand response rewards. A load reduction capability factor of batteries is determined with a real-time controller corresponding to an amount of energy to fulfill the demand response rewards. The net energy demand is compared with the demand threshold to determine a demand difference. Battery charge levels of the one or more batteries are controlled with the real time controller according to the demand difference and the load reduction capability factor.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 16, 2019
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma, Ali Hooshmand
  • Publication number: 20190113549
    Abstract: A computer-implemented method, system, and computer program product are provided for anomaly detection in a power system. The method includes receiving, by a processor-device, a plurality of measurements from a plurality of meters throughout the power system. The method also includes generating, by the processor-device, temporal causal networks based on pair-wise relationships between the plurality of measurements from the plurality of meters over time. The method additionally includes determining, by the processor-device, invariant relationships for the plurality of meters between the temporal causal networks. The method further includes predicting, by the processor-device, an anomaly from the invariant relationships for the plurality of meters with a residual anomaly threshold. The method also includes disabling one of the plurality of meters that originated the anomaly.
    Type: Application
    Filed: October 4, 2018
    Publication date: April 18, 2019
    Inventors: Kiyoshi Nakayama, Chenrui Jin, Ratnesh Sharma, Nikhil Muralidhar
  • Patent number: 10245263
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: April 2, 2019
    Assignee: ArQule, Inc.
    Inventors: Jean-Marc Lapierre, Sudharshan Eathiraj, Nivedita Namdev, Brian Schwartz, Yusuke Ota, Takayuki Momose, Tomoyuki Tsunemi, Hiroaki Inagaki, Kiyoshi Nakayama
  • Publication number: 20180330250
    Abstract: A computer-implemented method for detecting and predicting anomalies in an energy management system is presented. The method includes detecting, in real-time, a first set of outliers for a plurality of energy devices under operation, predicting a second set of outliers for running the plurality of energy devices, analyzing historical energy data of the plurality of energy devices to extract a third set of outliers, receiving feedback, in real-time, from a user regarding each of the first, second, and third sets of outliers, and training the energy management system with the real-time feedback received from the user to automatically optimize a threshold of error detection.
    Type: Application
    Filed: May 8, 2018
    Publication date: November 15, 2018
    Applicant: NEC Laboratories America, Inc.
    Inventors: Kiyoshi Nakayama, Ratnesh Sharma
  • Patent number: 10103550
    Abstract: A method of aggregated virtual power plant (VPP) control includes receiving control variable values. The control variables are received for control variables related to energy production and loads of devices electrically coupled to an electrical grid and communicatively coupled to the VPP controller server. The method includes inputting the control variable values into an objective algorithm. The method may include executing the objective algorithm. Executing the objective algorithm includes adjusting energy loads and energy production of prosumers, adjusting an energy amount supplied from a supply side for multiple time intervals, and adjusting curtailment of the energy loads in the prosumers based thereon. The method includes generating a VPP DR event schedule and communicating it to VPP client servers. The VPP DR event schedule includes control signals that are configured to affect an operating condition of the devices that are controlled by the VPP client servers.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: October 16, 2018
    Assignee: FUJITSU LIMITED
    Inventors: Kiyoshi Nakayama, Wei-Peng Chen