Patents by Inventor Kiyoteru Nagahara

Kiyoteru Nagahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10221435
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 5, 2019
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 10011681
    Abstract: Provided is a purified lactic acid-glycolic acid copolymer, preferably in the form of powder, having a reduced content of dimers such as residual lactide and glycolide that can be produced by a simple industrial process without the use of any high-shear special device. Further provided is a high-purity lactic acid-glycolic acid copolymer which has small amounts of dimers such as residual lactide and glycolide and small amounts of a low-molecular weight lactic acid-glycolic acid copolymer or a salt thereof and which has a small ratio of weight average molecular weight to number average molecular weight (Mw/Mn). The copolymer can be produced in accordance with a defined process.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: July 3, 2018
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Kiyoteru Nagahara, Yasushi Fukuiri, Tomoyuki Kawabata
  • Publication number: 20170327853
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: June 6, 2017
    Publication date: November 16, 2017
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Tadashi ARAKI, Tomonori HIDESAKI, Seiichi WATANABE, Keita NISHIDA, Kiyoteru NAGAHARA, Mitsuo KOITO
  • Patent number: 9695452
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 4, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Publication number: 20160060388
    Abstract: Provided is a purified lactic acid-glycolic acid copolymer, preferably in the form of powder, having a reduced content of dimers such as residual lactide and glycolide that can be produced by a simple industrial process without the use of any high-shear special device. Further provided is a high-purity lactic acid-glycolic acid copolymer which has small amounts of dimers such as residual lactide and glycolide and small amounts of a low-molecular weight lactic acid-glycolic acid copolymer or a salt thereof and which has a small ratio of weight average molecular weight to number average molecular weight (Mw/Mn). The copolymer can be produced in accordance with a defined process.
    Type: Application
    Filed: April 8, 2014
    Publication date: March 3, 2016
    Applicant: MITSUI CHEMICALS., INC.
    Inventors: Kiyoteru NAGAHARA, Yasushi FUKUIRI, Tomoyuki KAWABATA
  • Publication number: 20160046970
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: October 30, 2015
    Publication date: February 18, 2016
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Tadashi ARAKI, Tomonori HIDESAKI, Seiichi WATANABE, Keita NISHIDA, Kiyoteru NAGAHARA, Mitsuo KOITO
  • Patent number: 9212376
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: December 15, 2015
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Publication number: 20120077233
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: February 24, 2011
    Publication date: March 29, 2012
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 7919285
    Abstract: This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: April 5, 2011
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 7629457
    Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: December 8, 2009
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Ichirou Ikeda, Kaori Matoishi, Reiko Abe, Toshihiro Oikawa, Yasuko Matsuba, Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri
  • Publication number: 20080293098
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: October 7, 2005
    Publication date: November 27, 2008
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Publication number: 20050233420
    Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
    Type: Application
    Filed: October 19, 2004
    Publication date: October 20, 2005
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Ichirou Ikeda, Kaori Matoishi, Reiko Abe, Toshihiro Oikawa, Yasuko Matsuba, Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri
  • Patent number: 6936709
    Abstract: A protected 2?-deoxycytidine is purified by precipitating the protected 2?-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2?-deoxycytidine and water, and by recovering the protected 2?-deoxycytidine: wherein R1 represents a 4-methoxytrityl, 4, 4?-dimethoxytrityl, or triphenylmethyl group; and B1 represents a cytosine group having a protected amino group. The compound represented by general formula (3) is, in particular, a protected 2?-deoxycytidine represented by formula (4): The 2?-deoxycytidine is used as a raw material for antisense DNA.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 30, 2005
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri, Yasuko Matsuba
  • Patent number: 6858721
    Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: February 22, 2005
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Ichirou Ikeda, Kaori Matoishi, Reiko Abe, Toshihiro Oikawa, Yasuko Matsuba, Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri
  • Publication number: 20040219646
    Abstract: In reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in an aqueous reaction medium in the presence of a metal cation to produce a nucleoside compound, the timing or method of addition of at least one of these components to the aqueous reaction medium is varied; thereby, a nucleoside compound can be produced at a high yield efficiently without inviting the high viscosity or solidification of the reaction mixture, even when the above components are used in such amounts that the reaction mixture becomes highly viscous or is solidified when the components are used without the above variation of the addition timing or method. Thus, there can be provided a process for producing a nucleoside compound, which comprises a step of reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in the presence of nucleoside phosphorylase activity, which gives a nucleoside compound at an improved conversion, and which has wide applicability.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 4, 2004
    Inventors: Tadashi Araki, Ichiro Ikeda, Katsuyuki Takahashi, Kiyoshi Ito, Tamotsu Asano, Seiya Nikumaru, Takeshi Nakamura, Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri
  • Publication number: 20030229223
    Abstract: A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2′-deoxycytidine: 1
    Type: Application
    Filed: June 4, 2003
    Publication date: December 11, 2003
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri, Yasuko Matsuba
  • Publication number: 20030207405
    Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
    Type: Application
    Filed: April 30, 2002
    Publication date: November 6, 2003
    Inventors: Tadashi Araki, Ichirou Ikeda, Kaori Matoishi, Reiko Abe, Toshihiro Oikawa, Yasuko Matsuba, Hiroki Ishibashi, Kiyoteru Nagahara, Yasushi Fukuiri