Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.

Abstract: Disclosed is a fluid interception device for a cleaning and disinfecting system for medical devices, equipped with a processing chamber, including a hollow box-shaped condenser body, including: a transit port, in fluid communication with a transit duct of the cleaning and disinfecting system; and a vent port in communication with the external environment. The hollow box-shaped condenser body includes: condensation nozzles, in fluid communication with drain holes in a lower portion of the hollow box-shaped condenser body; and water feeding nozzles, above and in fluid communication with the transit port. Between the condensation nozzles and water feeding nozzles, a separation septum being arranged which defines and divides a condensation chamber and a feeding chamber. The transit port is arranged on the side of the feeding chamber and the separation septum providing at least one flow port which places the transit port in communication with the condensation chamber.

Abstract: An image processing method to provide a final panoramic image of at least a portion of a head of a patient, wherein a plurality of different provisional panoramic images are calculated from captured frame data sets through the variation of a reconstruction parameter; the provisional panoramic images are scanned for recognizable structures; the imaging quality of the recognizable structures is determined; the variation of the at least one reconstruction parameter for the calculation of different provisional panoramic images of those frame data sets which have recognizable structures with the highest imaging quality is determined; and with reference to the determined variation of the reconstruction parameter of step a final panoramic image is calculated. A computer-readable storage medium comprising instructions which cause a computer to perform the method and an imaging system having such a storage medium are also described.

Abstract: A tool holder which is provided with a plurality of different free jet turbines so that it can be operated, depending on the machining task, with different working rotational speeds and in different operating points.

Abstract: The disclosure relates to a method and to an image processing facility configured to carry out the method for the segmentation of image data of a target object. In the method, a first segmentation is generated by a trained algorithm. Furthermore, a statistical shape and appearance model is provided, which is trained on corresponding target objects. An interference region is further determined, in which the image data is impaired by an image artifact. A final segmentation of the image data is then generated by adjusting the shape and appearance model to the respective target object outside the interference region and using the first segmentation in the interference region.

Abstract: A multi-part adjusting element is proposed, which makes possible a very precise adjustment of a shaft bearing.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: The disclosure relates to a method and to an image processing facility configured to carry out the method for the segmentation of image data of a target object. In the method, a first segmentation is generated by a trained algorithm. Furthermore, a statistical shape and appearance model is provided, which is trained on corresponding target objects. An interference region is further determined, in which the image data is impaired by an image artifact. A final segmentation of the image data is then generated by adjusting the shape and appearance model to the respective target object outside the interference region and using the first segmentation in the interference region.

Abstract: A multi-part adjusting element is proposed, which makes possible a very precise adjustment of a shaft bearing.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: A sterilization method and system are disclosed, where a sterilization cycle includes at least an evacuation step of a sterilization chamber is performed one or more times and provides that: the chamber is isolated from the condenser; at least a steam generator is operated to inject a predetermined amount of heated steam directly into the condenser; the steam in the condenser is cooled and condensed, so as to reduce its volume and accordingly lower the pressure within the condenser to below that present in the sterilization chamber; and the condenser is placed in communication with the sterilization chamber to perform an evacuation.

Abstract: A domestic refrigeration appliance has a housing in which there is formed at least one receiving space for food that is delimited by walls of an internal container. An icemaker has an external housing that is separate from the internal container and that is preferably inserted in an inset region of the internal container and that has a charging opening. A separate frame is arranged on a front edge of the external housing. The separate frame delimits the charging opening.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: There is described a method and a system for monitoring a medical, in particular dental, device comprising at least two components, wherein at least one process parameter of the medical device which is sensitive to the functioning of the at least two components, is measured and stored for a plurality of operation cycles of the medical device and a maintenance requirement is recorded, when the process parameter reaches at least one preset and/or over a plurality of operation cycles calculated reference value, wherein a control unit assigns a maintenance requirement to one of the at least two components based on probabilistic evaluation of the recorded process parameters.

Abstract: A system is proposed that is made up of a tool holder 1, a collet 15 with a clamping nut 19, and a tool insert 27, in which the collet 15 and the tool insert are fixed and positioned on various function surfaces within the tool holder 1. Nevertheless, the clamping means are the same, namely a thread on the tool holder 1.

Abstract: A sterilization method and system are disclosed, where a sterilization cycle includes at least an evacuation step of a sterilization chamber is performed one or more times and provides that: the chamber is isolated from the condenser; at least a steam generator is operated to inject a predetermined amount of heated steam directly into the condenser; the steam in the condenser is cooled and condensed, so as to reduce its volume and accordingly lower the pressure within the condenser to below that present in the sterilization chamber; and the condenser is placed in communication with the sterilization chamber to perform an evacuation.

Abstract: A domestic refrigeration appliance has a housing in which there is formed at least one receiving space for food that is delimited by walls of an internal container. An icemaker has an external housing that is separate from the internal container and that is preferably inserted in an inset region of the internal container and that has a charging opening. A separate frame is arranged on a front edge of the external housing. The separate frame delimits the charging opening.

Abstract: There is described a method and a system for monitoring a medical, in particular dental, device comprising at least two components, wherein at least one process parameter of the medical device which is sensitive to the functioning of the at least two components, is measured and stored for a plurality of operation cycles of the medical device and a maintenance requirement is recorded, when the process parameter reaches at least one preset and/or over a plurality of operation cycles calculated reference value, wherein a control unit assigns a maintenance requirement to one of the at least two components based on probabilistic evaluation of the recorded process parameters.

Abstract: A cleaning, disinfecting, care and/or sterilization device for at least one medical or dental instrument comprising a housing, a treatment chamber for receiving the at least one medical or dental instrument, a media supply for feeding and/or discharging media into the treatment chamber and a control unit operable to control and/or regulate a cleaning, disinfecting, care and/or sterilization process, wherein the control unit comprises a wireless communication device to communicate with remote accessories of the cleaning, disinfecting, care and/or sterilization device and wherein the wireless communication device is capable of creating a wireless local area network allowing the remote accessories to communicate with the control unit of the cleaning, disinfecting, care and/or sterilization device.