Patents by Inventor Klaus E. Kuettner

Klaus E. Kuettner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080213807
    Abstract: Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders.
    Type: Application
    Filed: April 28, 2008
    Publication date: September 4, 2008
    Applicants: RUSH-PRESBYTERIAL-ST. LUKE'S MEDICAL CENTER, STRYKER CORPORATION
    Inventors: Susanna Chubinskaya, David C. Rueger, Klaus E. Kuettner
  • Patent number: 6720156
    Abstract: The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BIAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: April 13, 2004
    Assignees: SmithKline Beecham Corporation, Rush-Presbyterian St Luke's Medical Center
    Inventors: Jeff T. Hutchins, Klaus E. Kuettner, Kathryn Mason Lindley, Thomas M. Schmid, Barbara L. Schumacher, Stephen Anthony Stimpson, Jui-Lan Su
  • Publication number: 20030180948
    Abstract: The present invention relates to SZP polypeptides and nucleic acids encoding the polypeptides. The invention further relates to methods of making and using the polypeptides and nucleic acids. Also, the invention relates to immortalized chondrocytes or SZP-producing cells and methods of using the cells. The invention also relates to a method of culturing immortalized or non-immortalized chondrocytes in serum-free medium. The invention also relates to a method of imaging an articular surface or synovium of a joint using detectably tagged SZP or detectably tagged SZP binding proteins.
    Type: Application
    Filed: December 31, 2001
    Publication date: September 25, 2003
    Inventors: Jeff T. Hutchins, Klaus E. Kuettner, Thomas M. Schmid, Barbara L. Schumacher, Jui-Lan Su, Eric P. Dixon
  • Publication number: 20020192679
    Abstract: Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders.
    Type: Application
    Filed: February 20, 2002
    Publication date: December 19, 2002
    Inventors: Susanna Chubinskaya, David C. Rueger, Klaus E. Kuettner
  • Publication number: 20020009761
    Abstract: The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BlAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.
    Type: Application
    Filed: February 9, 2001
    Publication date: January 24, 2002
    Inventors: Jeff T. Hutchins, Klaus E. Kuettner, Kathryn Mason Lindley, Thomas M. Schmid, Barbara L. Schumacher, Stephen Anthony Stimpson, Jui-Lan Su
  • Patent number: 4746729
    Abstract: A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: May 24, 1988
    Inventors: Klaus E. Kuettner, Dominique Tripier, Dietrich Brocks, Michael T. DiMuzio
  • Patent number: 4356261
    Abstract: Chondrocytes are cultured to produce cartilage tissue from which an anti-invasion factor (AIF) may be recovered. Mammalian cartilage providing at least about 60% viable chondrocytes is enzymatically digested to denude the cells of their extracellular matrix. The denuded cells are plated at high density and cultured to produce cartilage tissue.
    Type: Grant
    Filed: April 22, 1980
    Date of Patent: October 26, 1982
    Assignee: Rush-Presbyterian-St. Luke's Medical Center
    Inventor: Klaus E. Kuettner
  • Patent number: 4176177
    Abstract: A method for regulating bone resorption wherein the bone is exposed to an effective amount of a composition of matter obtained from avascular or poorly vascularized tissue by extracting the tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted and recovering from the aqeuous extract substances having molecular weight below about 50,000.
    Type: Grant
    Filed: November 16, 1978
    Date of Patent: November 27, 1979
    Assignee: Rush-Presbyterian-St. Luke's Medical Center
    Inventor: Klaus E. Kuettner
  • Patent number: 4042457
    Abstract: A composition of matter having activity as an inhibitor of cell proliferation is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: August 16, 1977
    Assignee: Rush-Presbyterian-St. Luke's Medical Center
    Inventors: Klaus E. Kuettner, Reuben Eisenstein, Nino Sorgente
  • Patent number: RE30239
    Abstract: A composition of matter having activity as an inhibitor of cell proliferation .Iadd.and tissue invasion.Iaddend.is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: March 25, 1980
    Inventors: Klaus E. Kuettner, Reuben Eisenstein, Nino Sorgente