Patents by Inventor Klaus Gebauer

Klaus Gebauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190154639
    Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube (3,19,21) having a closed first end (5) comprising an inlet/outlet (7), a media inlet (15) adjacent a second end of the column tube and an adaptor (9) positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.
    Type: Application
    Filed: January 6, 2017
    Publication date: May 23, 2019
    Inventors: Klaus Gebauer, Dan Hermansson
  • Patent number: 10261057
    Abstract: The invention discloses a flow control block for a stack of chromatography column modules, as well as a stack of chromatography modules comprising at least one flow control block. The flow control block is in a first position or configuration capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: April 16, 2019
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Klaus Gebauer, Mats Lundkvist, Bjorn Olovsson
  • Publication number: 20190043333
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Application
    Filed: October 1, 2018
    Publication date: February 7, 2019
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Publication number: 20190038996
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Applicant: GE Healthcare BioProcess R&D AB
    Inventor: KLAUS GEBAUER
  • Patent number: 10195416
    Abstract: An apparatus for substantially sterile connection of flexible tubing, including at least one tubing holder, which is adapted to receive one or more lengths of flexible tubing and which is also equipped with one or more sterilant applicators. The sterilant applicator is adapted to apply a sterilant to the length of tubing when the tubing length is received in the tubing holder. At least one cutter, which is movable in relation to the tubing holder and adapted to cut the length of tubing. A connector holder, which includes a compartment housing and a substantially sterile tubing connector. The connector holder is movable in relation to the tubing holder to a position where the length of tubing and the sterile tubing connector are aligned and can be urged together.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: February 5, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Klaus Gebauer, Eric Faldt, Nachiket Karmarkar
  • Patent number: 10183236
    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the center of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 22, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Publication number: 20190015799
    Abstract: A rigid housing comprising a bottom part and at least one wall part, said bottom part and said at least one wall part together defining an internal volume when the bottom part is provided below the at least one wall part in a processing position, said rigid housing being arranged for holding a flexible bag within the internal volume, wherein the bottom part is rotatable about an axis of rotation, wherein said axis of rotation is substantially parallel to a longitudinal axis of said rigid housing such that the bottom part can be provided in a loading position in which the bottom part has been rotated out from the position below the at least one wall part.
    Type: Application
    Filed: January 4, 2017
    Publication date: January 17, 2019
    Inventors: Klaus Gebauer, Peter Toreheim, Patrik Akerstrom, Patrick Jonsson
  • Publication number: 20180361272
    Abstract: The invention discloses a chromatography column module stackable with like chromatography modules, comprising a column chamber (2) fluidically connected to a column inlet 3) and a column outlet (4), wherein the column inlet and outlet each comprise a valve (5), arranged to move from a closed position to an open position upon connection of the column inlet or outlet with a) a column outlet or inlet of a like chromatography module or b) with an outlet or inlet of a fluidics plate. The invention further discloses a stack of chromatography column modules and the use of the stack for separation of biomolecules.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 20, 2018
    Inventors: Dan Hermansson, Klaus Gebauer, Mats Lundkvist
  • Publication number: 20180356375
    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 13, 2018
    Applicant: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Publication number: 20180304199
    Abstract: A method and a system for improving mixing of content in a container 3 provided in a filter system 1, said method comprising providing a mixing loop 13 parallel to a recirculation flow path 11 of the filter system 1.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Inventors: Klaus Gebauer, Partha Sarathy Doddapadam Srinivasa Raghavachar, Narendra G R, Nachiket Karmarkar, Ajit S. Vernekar, Prashanth Hosabettu Mohan, Sasi Kumar Nutalapati
  • Patent number: 10099047
    Abstract: A separation or reaction unit (1; 1?; 81; 81?; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1?; 81; 81?; 101) comprises at last one fluid inlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: October 16, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Patent number: 10094481
    Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Ekta Mahajan, Eric Faldt
  • Patent number: 10092856
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Patent number: 10089850
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: October 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Publication number: 20180229152
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Applicant: GE Healthcare BioProcess R&D AB
    Inventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
  • Patent number: 10048235
    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: August 14, 2018
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Publication number: 20180221823
    Abstract: The disclosed subject matter relates to an automated CFF/TFF system that provides the operations of system treatment with a system treatment solution(such as buffer) and filtration of a solution (e.g., a biofluid) can be accomplished in succession without having to re-configure the system (such as re-routing the fluid conduits) that could compromise the integrity of the system. As a result, there will be reduced contamination risk, reduced volume of buffer required and will save time for the filtration process.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 9, 2018
    Inventors: Sasi Kumar Nutalapati, Klaus Gebauer, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Ajit S. Vernekar, Amit Kumar Sharma, Fredrik Oskar Lundstrom
  • Publication number: 20180221822
    Abstract: The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 9, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Sasi Kumar Nutalapati, Klaus Gebauer, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Amit S. Vernekar, Ajit Kumar Sharma, Fredrik Oskar Lundstrom, Sangeetha Raghu Ramachandran
  • Patent number: 9975658
    Abstract: A disposable container comprising a side wall, top and bottom, wherein the side wall comprises a first flexible material and the bottom comprises a rigid or semi-rigid material. The side wall top and bottom are joined together to define the container with an interior compartment for keeping a fluid inside the container. The bottom comprises at least one opening that is fluid-tightly covered with an assembly comprising a second flexible material. The assembly comprises at least one port which provides access to the interior compartment of the container. The invention also relates to a mixing system comprising the disposable container.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: David Rönnholm, Klaus Gebauer, Rolf Hjorth, Patrick Jonsson
  • Patent number: 9958421
    Abstract: The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: May 1, 2018
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Klaus Gebauer, Elisabeth Hallgren, Raf Lemmens, Ola Lind, Bjorn Lundgren, Jamil Shanagar, Kajsa Stridsberg-Friden, Helena Widegren