Patents by Inventor Klaus Gebauer

Klaus Gebauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9950277
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: April 24, 2018
    Assignee: GE HEALTHCARE BIOPROCESS R&D AB
    Inventor: Klaus Gebauer
  • Patent number: 9943781
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: April 17, 2018
    Assignee: GE HEALTHCARE BIOPROCESS R&D AB
    Inventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Uselius
  • Publication number: 20180043284
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Application
    Filed: October 25, 2017
    Publication date: February 15, 2018
    Applicant: GE Healthcare BioProcess R&D AB
    Inventor: KLAUS GEBAUER
  • Publication number: 20170361245
    Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication Go between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the
    Type: Application
    Filed: December 23, 2015
    Publication date: December 21, 2017
    Inventors: Klaus Gebauer, Bjorn Markus Olovsson
  • Publication number: 20170341043
    Abstract: Embodiments of the method disclosed regard use of a torque sensor (e.g., transducer) and using the measured torque to detect the different fluid and mixing properties, conditions, and abnormalities in a mixing process. The torque produced in the mixing process relates to different fluid properties such as viscosity and density. It also relates to different mixing conditions such as presence of obstacles and changes or issues with gas sparging. Moreover, torque measurements enable determination of power transmitted to fluid by actual measurement, in contrast to using solely empirical impeller power number and speed, and allowing for actual mass transfer determination (i.e., gas transfer calculations).
    Type: Application
    Filed: May 27, 2016
    Publication date: November 30, 2017
    Inventors: Ashraf Said Atalla, Klaus Gebauer, Sima Didari
  • Publication number: 20170282137
    Abstract: The system and method of the invention pertains to use of a back iron on one or both ends of the impeller to increase the magnetic field density, and thus strengthen the magnetic coupling. In addition, pie-shaped (i.e. wedge) magnets, or variations thereof, increase the utilization volume and hence provide higher torque to allow the use of less expensive material (e.g. ferrites). In another embodiment, the rotor side is constructed with a Halbach array which increases the torque without the need to add a back iron piece. In another embodiment, an axial flux stator is implemented to replace the drive-end magnets and the drive motor.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Inventors: Ashraf Said Atalla, Klaus Gebauer, Richard Lee Damren, David Allan Torrey, Sima Didari
  • Publication number: 20170281921
    Abstract: The invention relates to a An aseptic connector comprising a first connection unit (102; 202; 302; 402; 502) provided with a first terminal end surface (104; 204; 304; 404; 504) and a second connection unit (106; 206; 306; 406; 506) provided with a second terminal end surface (108; 208; 308; 408; 508); said first and second terminal end surfaces are each provided with at least one first and second opening (110, 112; 210, 212; 310, 312; 410, 412; 510, 512), which openings are orientated to substantially coincide when said first and second connection units are connected to each other; said first and second openings are sealed by at least one film (114; 214; 314; 414; 514) arranged on said first and second connection units, so that the contact between the film and each connection unit is aseptic; said at least one film is adapted to be mated with a corresponding film on the other connection unit when said first and second connection units are connected to each other; and said mated films are adapted to be pulled
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Eric Faldt, Klaus Gebauer
  • Publication number: 20170282138
    Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Inventors: Ashraf Said Atalla, Klaus Gebauer, James Pellegrino Alexander, David Allan Torrey
  • Publication number: 20170219541
    Abstract: The invention discloses a flow control block for a stack of chromatography column modules, as well as a stack of chromatography modules comprising at least one flow control block. The flow control block is in a first position or configuration capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series.
    Type: Application
    Filed: July 6, 2015
    Publication date: August 3, 2017
    Inventors: Klaus Gebauer, Mats Lundkvist, Bjorn Olovsson
  • Patent number: 9718028
    Abstract: The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate o
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 1, 2017
    Assignee: General Electric Company
    Inventors: Karl Ekstrom, Klaus Gebauer, Hakan Lundstrom, Patrik Akerstrom
  • Publication number: 20170182432
    Abstract: The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.
    Type: Application
    Filed: March 14, 2017
    Publication date: June 29, 2017
    Applicant: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Patent number: 9675947
    Abstract: The present invention relates to a mixing system comprising a vessel (1) for housing a disposable fluid mixing bag (2), which vessel (1) comprises a base (3) supporting the fluid mixing bag (2) and a sidewall (4) extending vertically upwards from the base (3). The sidewall (4) of the vessel comprises a door opening (5) which is closable by a sliding door (6). The system with the sliding door provides an easy access to the inside of the vessel (1) in a space saving manner.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 13, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Patrick Jonsson, David Ronnholm
  • Patent number: 9663753
    Abstract: The invention discloses a system for perfusion culture of cells which comprises: a bioreactor; a filter unit with a retentate inlet end, a retentate outlet end and a permeate outlet port; a reciprocating pump fluidically connected to the retentate inlet end, with the retentate inlet end fluidically connected to the bioreactor via an inlet check valve arranged to allow flow in the direction from the bioreactor to the retentate inlet end and to block flow in the reverse direction, and where the retentate outlet end is fluidically connected to the bioreactor via an outlet check valve arranged to allow flow in the direction from the retentate outlet end to the bioreactor and to block flow in the reverse direction; and where the inlet and outlet check valves are each fluidically connected to a tubing branch point, which is further connected to the bioreactor via a length of tubing.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: May 30, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Publication number: 20170124845
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 4, 2017
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Publication number: 20170097327
    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
    Type: Application
    Filed: December 14, 2016
    Publication date: April 6, 2017
    Applicant: GE Healthcare BioProcess R&D AB
    Inventor: KLAUS GEBAUER
  • Patent number: 9597610
    Abstract: The invention relates to a system for packing chromatography columns with a chromatography medium and packing method for use in such columns. In particular, the invention relates to a method and system for packing chromatography columns where the column and chromatography media are pre-sterilized.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: March 21, 2017
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Patent number: 9597611
    Abstract: A method for providing an aseptic chromatography column includes the steps of pre-sterilizing an empty chromatography column, pre-sterilizing a chromatography medium, introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thus providing an aseptic chromatography column comprising chromatography medium.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: March 21, 2017
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Publication number: 20170044477
    Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
    Type: Application
    Filed: April 27, 2015
    Publication date: February 16, 2017
    Inventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
  • Patent number: 9571904
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: February 14, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: D802710
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: November 14, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Amit Kumar Singh, Klaus Gebauer, Supti Datta, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Ajit S. Vernekar, Mats Olsson, Amit Kumar Sharma, Sasi Kumar Nutalapati, Fredrik Oskar Lundstrom, Jean Pierre Neff