Patents by Inventor Klaus-Juergen Pees
Klaus-Juergen Pees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7329663Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 29, 2001Date of Patent: February 12, 2008Assignee: WyethInventors: Mark R. Schmitt, Donald R. Kirsch, Jane E. Harris, Carl F. Beyer, Klaus-Jüergen Pees, Paul A. Carter, Waldemar Pfrengle, Guido Albert
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Publication number: 20070208037Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, ?wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or ?R1 and R5 together with the interjacent nitrogen atom form a hetType: ApplicationFiled: May 7, 2007Publication date: September 6, 2007Inventors: Klaus-Juergen PEES, Waldemar Pfrengle, Gavin Heffernan
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Patent number: 7230104Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a heteroType: GrantFiled: July 22, 2005Date of Patent: June 12, 2007Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Patent number: 7105664Abstract: 5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines of formula I: (I) in which R1 is hydrogen, fluoro, alkyl, alkenyl, alkynyl, alkadienyl, where the carbon chains of these radicals may be unsubstituted or substituted as defined in the description; R2 is hydrogen, alkyl, alkenyl, alkynyl, alkadienyl, where these radicals may be unsubstituted or substituted; R3 is fluoroalkyl or fluoroalkenyl; X is halogen; n is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy. Processes for their preparation, compositions containing them and to their use for combating phytopathogenic fungi.Type: GrantFiled: April 6, 2002Date of Patent: September 12, 2006Assignee: BASF AktiengesellschaftInventors: Jordi Tormo i Blasco, Eberhard Ammermann, Klaus-Jürgen Pees, Guido Albert, Annerose Rehnig, Debra Search
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Patent number: 7084146Abstract: The novel compounds of formula I: wherein R1 is hydrogen or methyl; R2 is hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl or phenyl group; Hal is halogen; and L1 through L5 are each hydrogen, halogen, alkyl, alkoxy or nitro, provided that at least one of L1 through L5 represents nitro or alkoxy; show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: April 23, 2001Date of Patent: August 1, 2006Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
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Publication number: 20050282847Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a heType: ApplicationFiled: July 22, 2005Publication date: December 22, 2005Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Publication number: 20050282828Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, MR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a heType: ApplicationFiled: July 22, 2005Publication date: December 22, 2005Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Patent number: 6943252Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a heterType: GrantFiled: July 9, 2003Date of Patent: September 13, 2005Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Publication number: 20040147744Abstract: Pyrimidines of formula I 1Type: ApplicationFiled: July 9, 2003Publication date: July 29, 2004Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Patent number: 6730680Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I wherein R1 is alkyl, alkenyl, alkynyl, alkadienyl or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, where these radicals may be unsubstituted or substituted as defined in the specification, Y is oxygen, sulfur, NR2 or a single bond; wherein R2 is defined in the specification; and R1 and R2 together with the interjacent nitrogen atom may represent a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted by one or more Rc radicals; m is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, alkoxy, and X is halogen; processes and intermediates fType: GrantFiled: December 10, 2002Date of Patent: May 4, 2004Assignee: BASF AktiengesellschaftInventors: Klaus Jüergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
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Patent number: 6632821Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atoType: GrantFiled: June 12, 2001Date of Patent: October 14, 2003Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Publication number: 20030158190Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I 1Type: ApplicationFiled: December 10, 2002Publication date: August 21, 2003Inventors: Klaus Juergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Muller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schafer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Reinhard Stierl
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Publication number: 20030088096Abstract: Pyrimidines of formula I 1Type: ApplicationFiled: June 12, 2001Publication date: May 8, 2003Applicant: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
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Patent number: 6559151Abstract: 6-(2-Trifluoromethyl-phenyl)-triazolopyrimidines of formula I in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, alkadienyl, or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or where R1 and R2 radicals may be unsubstituted or substituted as defined in the specification; or R1 and R2 together with the interjacent nitrogen atom represents a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted as defined in the specification; R3 is hydrogen, halogen, alkyl, alkoxy and haloalkyl; and X is halogen; processes and intermediates for preparing these compounds, compositions comprising them aType: GrantFiled: December 12, 2000Date of Patent: May 6, 2003Assignee: BASF AktiengesellschaftInventors: Klaus Jüergen Pees, Frank Schieweck, Jordi Tormo I Blasco, Hubert Sauter, Oliver Cullman, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schäfer, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
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Patent number: 6552026Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I wherein R1 is alkyl, alkenyl, alkynyl, alkadienyl or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, where these radicals may be unsubstituted or substituted as defined in the specification, Y is oxygen, sulfur, NR2 or a single bond; wherein R2is defined in the specification; and R1 and R 2 together with the interjacent nitrogen atom may represent a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted by one or more Rc radicals; m is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, alkoxy, and X is halogen; processes and intermediates foType: GrantFiled: December 12, 2000Date of Patent: April 22, 2003Assignee: BASF AktiengesellschaftInventors: Klaus Jüergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
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Publication number: 20030055069Abstract: The novel compounds of formula I: 1Type: ApplicationFiled: April 23, 2001Publication date: March 20, 2003Applicant: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
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Publication number: 20020068744Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 29, 2001Publication date: June 6, 2002Applicant: American Home Products CorporationInventors: Mark R. Schmitt, Donald R. Kirsch, Jane E. Harris, Carl F. Beyer, Klaus-Juergen Pees, Paul A. Carter, Waldemar Pfrengle, Guido Albert
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Publication number: 20020061882Abstract: 6-(2-Trifluoromethyl-phenyl)-triazolopyrimidines of formula I 1Type: ApplicationFiled: December 12, 2000Publication date: May 23, 2002Applicant: BASF CorporationInventors: Klaus-Juergen Pees, Frank Schieweck, Jordi Tormo I Blasco, Hubert Sauter, Oliver Cullman, Bernd Muller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Reinhard Stierl
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Patent number: 6380202Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity and high systemicity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: April 30, 2002Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Annerose Rehnig, Guido Albert
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Patent number: RE40332Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity. The new compounds may be processed with carriers and adjuvants to produce fungicidal compositions.Type: GrantFiled: August 20, 2003Date of Patent: May 20, 2008Assignee: BASF AktiengesellschaftInventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle