Patents by Inventor Klaus-Juergen Pees

Klaus-Juergen Pees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7329663
    Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: February 12, 2008
    Assignee: Wyeth
    Inventors: Mark R. Schmitt, Donald R. Kirsch, Jane E. Harris, Carl F. Beyer, Klaus-Jüergen Pees, Paul A. Carter, Waldemar Pfrengle, Guido Albert
  • Publication number: 20070208037
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, ?wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or ?R1 and R5 together with the interjacent nitrogen atom form a het
    Type: Application
    Filed: May 7, 2007
    Publication date: September 6, 2007
    Inventors: Klaus-Juergen PEES, Waldemar Pfrengle, Gavin Heffernan
  • Patent number: 7230104
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a hetero
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: June 12, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Patent number: 7105664
    Abstract: 5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines of formula I: (I) in which R1 is hydrogen, fluoro, alkyl, alkenyl, alkynyl, alkadienyl, where the carbon chains of these radicals may be unsubstituted or substituted as defined in the description; R2 is hydrogen, alkyl, alkenyl, alkynyl, alkadienyl, where these radicals may be unsubstituted or substituted; R3 is fluoroalkyl or fluoroalkenyl; X is halogen; n is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy. Processes for their preparation, compositions containing them and to their use for combating phytopathogenic fungi.
    Type: Grant
    Filed: April 6, 2002
    Date of Patent: September 12, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Jordi Tormo i Blasco, Eberhard Ammermann, Klaus-Jürgen Pees, Guido Albert, Annerose Rehnig, Debra Search
  • Patent number: 7084146
    Abstract: The novel compounds of formula I: wherein R1 is hydrogen or methyl; R2 is hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl or phenyl group; Hal is halogen; and L1 through L5 are each hydrogen, halogen, alkyl, alkoxy or nitro, provided that at least one of L1 through L5 represents nitro or alkoxy; show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: August 1, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
  • Publication number: 20050282847
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a he
    Type: Application
    Filed: July 22, 2005
    Publication date: December 22, 2005
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Publication number: 20050282828
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxy-carbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, MR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a he
    Type: Application
    Filed: July 22, 2005
    Publication date: December 22, 2005
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Patent number: 6943252
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen atom form a heter
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: September 13, 2005
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Publication number: 20040147744
    Abstract: Pyrimidines of formula I 1
    Type: Application
    Filed: July 9, 2003
    Publication date: July 29, 2004
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Patent number: 6730680
    Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I wherein R1 is alkyl, alkenyl, alkynyl, alkadienyl or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom,  where these radicals may be unsubstituted or substituted as defined in the specification, Y is oxygen, sulfur, NR2 or a single bond; wherein R2 is defined in the specification; and R1 and R2 together with the interjacent nitrogen atom may represent a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted by one or more Rc radicals; m is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, alkoxy, and X is halogen; processes and intermediates f
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: May 4, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Jüergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
  • Patent number: 6632821
    Abstract: Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or tri-alkyl-silyl, formyl or alkoxycarbonyl, wherein R1 groups are unsubstituted or substituted as defined in the specification; R2 represents phenyl, cycloalkyl or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which are unsubstituted or substituted; R3 represents hydrogen, halogen or alkyl, alkoxy, alkylthio, alkylamino or dialkylamino; which are unsubstituted or substituted; R4 represents hydrogen or alkyl, alkenyl or alkynyl; which are unsubstituted or substituted; and X represents O, S, NR5 or a single bond, wherein R5 represents hydrogen or alkyl; or R1 and R5 together with the interjacent nitrogen ato
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: October 14, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Publication number: 20030158190
    Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I 1
    Type: Application
    Filed: December 10, 2002
    Publication date: August 21, 2003
    Inventors: Klaus Juergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Muller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schafer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Reinhard Stierl
  • Publication number: 20030088096
    Abstract: Pyrimidines of formula I 1
    Type: Application
    Filed: June 12, 2001
    Publication date: May 8, 2003
    Applicant: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Waldemar Pfrengle, Gavin Heffernan
  • Patent number: 6559151
    Abstract: 6-(2-Trifluoromethyl-phenyl)-triazolopyrimidines of formula I in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, alkadienyl, or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or where R1 and R2 radicals may be unsubstituted or substituted as defined in the specification; or R1 and R2 together with the interjacent nitrogen atom represents a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted as defined in the specification; R3 is hydrogen, halogen, alkyl, alkoxy and haloalkyl; and X is halogen; processes and intermediates for preparing these compounds, compositions comprising them a
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: May 6, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Jüergen Pees, Frank Schieweck, Jordi Tormo I Blasco, Hubert Sauter, Oliver Cullman, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schäfer, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
  • Patent number: 6552026
    Abstract: 6-Phenyl-Pyrazolopyrimidines of formula I wherein R1 is alkyl, alkenyl, alkynyl, alkadienyl or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or 5- or 6-membered heteroaryl, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom,  where these radicals may be unsubstituted or substituted as defined in the specification, Y is oxygen, sulfur, NR2 or a single bond; wherein R2is defined in the specification; and R1 and R 2 together with the interjacent nitrogen atom may represent a 5- or 6-membered heterocyclic ring, containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, which may be substituted by one or more Rc radicals; m is 0 or an integer from 1 to 4; L each independently is halogen, nitro, alkyl, alkoxy, and X is halogen; processes and intermediates fo
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: April 22, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Jüergen Pees, Jordi Tormo i Blasco, Hubert Sauter, Oliver Cullman, Markus Gewehr, Wassilios Grammenos, Bernd Müller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Rheinhard Stierl
  • Publication number: 20030055069
    Abstract: The novel compounds of formula I: 1
    Type: Application
    Filed: April 23, 2001
    Publication date: March 20, 2003
    Applicant: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle
  • Publication number: 20020068744
    Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 29, 2001
    Publication date: June 6, 2002
    Applicant: American Home Products Corporation
    Inventors: Mark R. Schmitt, Donald R. Kirsch, Jane E. Harris, Carl F. Beyer, Klaus-Juergen Pees, Paul A. Carter, Waldemar Pfrengle, Guido Albert
  • Publication number: 20020061882
    Abstract: 6-(2-Trifluoromethyl-phenyl)-triazolopyrimidines of formula I 1
    Type: Application
    Filed: December 12, 2000
    Publication date: May 23, 2002
    Applicant: BASF Corporation
    Inventors: Klaus-Juergen Pees, Frank Schieweck, Jordi Tormo I Blasco, Hubert Sauter, Oliver Cullman, Bernd Muller, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Eberhard Ammermann, Siegried Strathmann, Gisela Lorenz, Reinhard Stierl
  • Patent number: 6380202
    Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity and high systemicity. The new compounds are processed with carriers and adjuvants to fungicidal compositions.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: April 30, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Annerose Rehnig, Guido Albert
  • Patent number: RE40332
    Abstract: The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity. The new compounds may be processed with carriers and adjuvants to produce fungicidal compositions.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: May 20, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus-Juergen Pees, Guenter Krummel, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Leslie May, Waldemar Pfrengle