Patents by Inventor Klaus Linz

Klaus Linz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES
    Publication number: 20120202810
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: April 24, 2012
    Publication date: August 9, 2012
    Applicant: Grunenthal GmbH
    Inventors: Bert NOLTE, Wolfgang SHRÖDER, Klaus LINZ, Werner ENGLBERGER, Hans SCHICK, Heinz GRAUBAUM, Birgit ROLOFF, Sigrid OZEGOWSKI, József BÁLINT, Helmut SONNENSCHEIN
  • Substituted heteroaryl derivatives
    Patent number: 8138187
    Abstract: The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 20, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Werner Englberger, Babette-Yvonne Kögel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Heinz Graubaum, Claudia Hinze
  • Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds
    Publication number: 20120029006
    Abstract: Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the ?-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.
    Type: Application
    Filed: July 28, 2011
    Publication date: February 2, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Klaus Linz, Saskia Zemolka, Bert Nolte, Stefan Schunk, Hans Schick
  • Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds
    Publication number: 20110319440
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: September 2, 2011
    Publication date: December 29, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Claudia HINZE, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Compositions containing spirocyclic cyclohexane compounds
    Patent number: 8053576
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Spirocyclic cyclohexane compounds useful to treat substance dependency
    Patent number: 8034936
    Abstract: Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: October 11, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Elmar Friderichs, Babette-Yvonne Koegel, Klaus Linz
  • (Hetero)aryl cyclohexane derivatives
    Patent number: 7977370
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: July 12, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Bert Nolte, Klaus Linz, Wolfgang Schröder, Werner Englberger, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, József Bálint
  • Spirocyclic cyclohexane compounds
    Patent number: 7951948
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: May 31, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Hydroxymethylcyclohexylamines
    Publication number: 20110059999
    Abstract: The invention relates to compounds which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 10, 2011
    Applicant: GRÜNENTHAL GMBH
    Inventors: Sven Frormann, Saskia Zemolka, Klaus Linz, Werner Englberger, Fritz Theil
  • Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency
    Publication number: 20110053970
    Abstract: Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency.
    Type: Application
    Filed: November 4, 2010
    Publication date: March 3, 2011
    Applicant: GRUENENTHAL GMBH
    Inventors: Elmar FRIDERICHS, Babette-Yvonne Koegel, Klaus Linz
  • MIXED ORL1/MU-AGONISTS FOR THE TREATMENT OF PAIN
    Publication number: 20110015220
    Abstract: The invention relates to the use of compounds which exhibit an affinity for the ?-opioid receptor of at least 100 nM (Ki value, human) and an affinity for the ORL-1 receptor, wherein the ratio between the affinities ORL1/?defined as 1/[Ki(ORL1)/Ki(?)] is from 0.1 to 30, for the treatment of pain.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 20, 2011
    Applicant: GRUNENTHAL GMBH
    Inventors: KLAUS LINZ, BABETTE-YVONNE KÖGEL, WOLFGANG SCHRÖDER, THOMAS CHRISTOPH, JEAN DE VRY, ELMAR FRIDERICHS
  • Spirocyclic Cyclohexane Compounds
    Publication number: 20100240897
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: April 19, 2010
    Publication date: September 23, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Spirocyclic cyclohexane compounds
    Patent number: 7799931
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: September 21, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • SPIRO(5.5)UNDECANE DERIVATIVES
    Publication number: 20090247505
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GMBH
    Inventors: Saskia ZEMOLKA, Stefan SCHUNK, Klaus LINZ, Wolfgang SCHRODER, Werner ENGLBERGER, Fritz THEIL, Birgit ROLOFF
  • SUBSTITUTED CYCLOHEXYLDIAMINES
    Publication number: 20090247591
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain or other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GmbH
    Inventors: Saskia Zemolka, Bert Nolte, Klaus Linz, Derek John Saunders, Wolfgang Schroder, Wemer Englberger, Fritz Theil, Hans Schick, Jens Kaufmann, Julian Gebauer, Helmut Sonnenschein
  • SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES
    Publication number: 20090247561
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GmbH
    Inventors: Saskia Zemolka, Bert Nolte, Sven Frorman, Claudia Hinze, Klaus Linz, Wolfgang Schroder, Werner Englberger, Hans Schick, Helmut Sonnenschein
  • SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES
    Publication number: 20090247530
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GMBH
    Inventors: Bert NOLTE, Wolfgang SCHRODER, Klaus LINZ, Werner ENGLBERGER, Hans SCHICK, Heinz GRAUBAUM, Birgit ROLOFF, Sigrid OZEGOWSKI, Jozsef BALINT, Helmut SONNENSCHEIN
  • (HETERO)ARYL CYCLOHEXANE DERIVATIVES
    Publication number: 20090247573
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: GRUNENTHAL GMBH
    Inventors: Saskia Zemolka, Stefan Schunk, Bert Nolte, Klaus Linz, Wolfgang Schroder, Werner Englberger, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Jozsef Balint
  • Substituted 4-aminocyclohexane derivatives
    Publication number: 20090215725
    Abstract: Substituted 4-aminocyclohexane derivatives having the formula I: wherein R1-R4 are as described herein, methods for their preparation, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted 4-aminocyclohexane derivatives for treating pain.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 27, 2009
    Applicant: GRUNENTHAL GMBH
    Inventors: Stefan SCHUNK, Saskia ZEMOLKA, Klaus LINZ, Werner ENGLBERGER, Fitz THEIL
  • SPIROCYCLIC CYCLOHEXANE COMPOUNDS
    Publication number: 20090163716
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: February 17, 2009
    Publication date: June 25, 2009
    Applicant: GRUENENTHAL GmbH
    Inventors: Claudia HINZE, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin