Patents by Inventor Klaus Nickisch

Klaus Nickisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140364600
    Abstract: Described herein are imidazolyl compounds which either act as pure antiprogestins and methods of using such pure antagonists for gynecological indications and breast cancer.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 11, 2014
    Inventors: Klaus Nickisch, Walter Elger, Bindu Santhamma
  • Patent number: 8673968
    Abstract: Described herein are compounds which exhibit progesterone antagonistic effects and methods of treating cancer using such compounds.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: March 18, 2014
    Assignee: Evestra, Inc.
    Inventors: Klaus Nickisch, James Cessac, Kesavaram Narkunan, Baishakhi Das
  • Publication number: 20130123523
    Abstract: Described herein is a process for the synthesis of etonogestrel and desogestrel and intermediates used to form etonogestrel and desogestrel.
    Type: Application
    Filed: November 10, 2011
    Publication date: May 16, 2013
    Inventors: Klaus Nickisch, Bindu Santhamma
  • Publication number: 20130029953
    Abstract: Described herein are compounds which either act as pure antiprogestins or as antiprogestins with partial agonistic activity and methods of treating cancer using such compounds.
    Type: Application
    Filed: July 28, 2011
    Publication date: January 31, 2013
    Inventors: Klaus Nickisch, Kesavaram Narkunan, Baishakhi Debnath, Bindu Santhamma
  • Patent number: 8334375
    Abstract: Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: December 18, 2012
    Assignee: Evestra, Inc.
    Inventors: Klaus Nickisch, Kirk Acosta, Bindu Santhamma
  • Patent number: 8222237
    Abstract: Described herein are 3-(6,6-ethylene-17?-hydroxy-3-oxo-17?-pregna-4-ene-17?-yl)propionic acid ?-lactone derivatives having progestational and aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: July 17, 2012
    Assignee: Evestra, Inc.
    Inventors: Klaus Nickisch, Pemmaraju Rao, Kesavaram Narkunan, James Cessac
  • Publication number: 20110250274
    Abstract: Disclosed herein are oral dosage forms and methods of their use, in particular oral dosage systems for the delivery of estriol compounds. Embodiments described herein relate to rapidly disintegrating oral dosage formulations that disintegrate in the saliva of the buccal and/or sublingual and/or esophageal cavity. Oral dosage forms described herein relate to stabilized amorphous and nanocrystalline forms of the active ingredients of the formulations.
    Type: Application
    Filed: September 18, 2009
    Publication date: October 13, 2011
    Inventors: Ze'ev Shaked, Walter Elger, Klaus Nickisch
  • Publication number: 20110236462
    Abstract: Described herein is an intravaginal drug delivery system. In an embodiment the intravaginal drug delivery system includes a progestin and estrogen compound, and releases the active ingredients in a fixed physiological ratio over a prolonged period of time to produce a contraceptive state in a female.
    Type: Application
    Filed: March 28, 2011
    Publication date: September 29, 2011
    Inventors: Ze'ev Shaked, Klaus Nickisch, James DiNunzio, Feng Zhang, Marcelo Omelczuk
  • Patent number: 7960368
    Abstract: Described herein are bismethylene-17? carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: June 14, 2011
    Assignee: Everstra, Inc.
    Inventors: Klaus Nickisch, Pemmaranu N. Rao, James W. Cessac, Anne Marie Simmons
  • Publication number: 20100273759
    Abstract: Described herein are compounds which exhibit progesterone antagonistic effects and methods of treating cancer using such compounds.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 28, 2010
    Inventors: Klaus Nickisch, James Cessac, Kesavaram Narkunan, Baishakhi Das
  • Publication number: 20100261896
    Abstract: Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 14, 2010
    Inventors: Klaus Nickisch, Kirk Acosta, Bindu Santhamma
  • Publication number: 20100137264
    Abstract: Described herein are 3-(6,6-ethylene-17?-hydroxy-3-oxo-17?-pregna-4-ene-17?-yl)propionic acid ?-lactone derivatives having progestational and aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Inventors: Klaus Nickisch, Pemmaraju Rao, Kesavaram Narkunan, James Cessac
  • Publication number: 20100130455
    Abstract: Described herein are bismethylene-17? carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
    Type: Application
    Filed: March 4, 2009
    Publication date: May 27, 2010
    Inventors: Klaus Nickisch, Pemmaranu N. Rao, James W. Cessac, Anne Marie Simmons
  • Patent number: 7547776
    Abstract: The present invention generally relates to a fludarabine-phosphate with a purity of at least 99.5%.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: June 16, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Ulf Tilstam, Thomas Schmitz, Klaus Nickisch
  • Patent number: 6933395
    Abstract: Process for the production of drospirenone (6?,7?; 15?,16?-dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7?-(3-hydroxy-1-propyl)-6?,7?; 15?,16?-dimethylene-5?-androstane-3?,5,17?-triol (ZK 92836) and 6?,7?; 15?,16?-dimethylene-5?-hydroxy-3-oxo-17?-androstane-21,17-carbolactone (ZK 90965) as intermediate products of the process.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: August 23, 2005
    Assignee: Schering AG
    Inventors: Jörg-Thorsten Mohr, Klaus Nickisch
  • Patent number: 6121465
    Abstract: Process for the production of drospirenone (6.beta., 7.beta.; 15.beta., 16.beta.-dimethylene-3-oxo-17.alpha.-pregn-4-ene-21, 17-carbolactone, DRSP) (1) and 7.alpha.-(3-hydroxy-1-propyl)-6.beta., 7.beta.; 15.beta., 16.beta.-dimethylene-5.beta.-androstane-3.beta., 5, 17.beta.-triol (ZK 92836) and 6.beta., 7.beta.; 15.beta., 16.beta.-dimethylene-5.beta.-hydroxy-3-oxo-17.alpha.-androstane-21, 17-carbolactone (ZK 90965) as intermediate products of the process.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: September 19, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Jorg-Thorsten Mohr, Klaus Nickisch
  • Patent number: 6046322
    Abstract: A reduced temperature crystallization process for the obtaining fludarabine phosphate at a purity of at least 99.5%.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: April 4, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulf Tilstam, Thomas Schmitz, Klaus Nickisch
  • Patent number: 5908944
    Abstract: This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compounds as well as a process for the 1,4-addition of a methyl or ethyl group to an .alpha.,.beta.-unsaturated or an .alpha.,.beta.-double unsaturated ketone or an .alpha.,.beta.-unsaturated aldehyde using the agent according to the invention.By using only catalytic amounts of copper and a CKW (chlorinatedhydrocarbon)-free reaction medium, the new methylation/ethylation agent/process is distinguished by its environmental compatibility and it is, for example, suitable for the production of initial products for the synthesis of biologically effective compounds.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: June 1, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Jurgen Westermann, Klaus Nickisch
  • Patent number: 5908945
    Abstract: Disclosed is an alkylating agent that contains an aluminum reagent Alk.sub.3-m AlL.sub.m, in which Alk means a methyl, ethyl, n- or i-propyl, n-, i- or tert-butyl, pentyl, hexyl, heptyl or octyl group, which all can also be branched, L means an ethoxy group, a chlorine or bromine atom, and m is equal to 1 or 2, as an alkyl source or else zinc dimethyl as a methyl source, which contains in addition catalytic amounts of one or more copper(I) and/or copper(II) compounds and one (or more) silyl reagent(s) of general formula IIIR.sup.1 R.sup.2 R.sup.3 SiZ (III),in whichR.sup.1, R.sup.2 and R.sup.3 are as defined herein, as well as a process for 1,4-addition of an alkyl group to an .alpha.,.beta.-unsaturated ketone or an .alpha.,.beta.-double unsaturated ketone or to an .alpha.,.beta.-unsaturated aldehyde with use of the agent according to the invention.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: June 1, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Jurgen Westermann, Klaus Nickisch
  • Patent number: 5744616
    Abstract: A process for the production of 1,4,7,10-tetraazacyclododecane (cyclene) and its derivatives on an industrial scale comprises cyclotetramerizing of benzylaziridine that is produced in situ.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: April 28, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Orlin Petrov, Annette Prelle, Klaus Graske, Klaus Nickisch, Bernd Raduchel, Johannes Platzek