Patents by Inventor Klaus Nickisch

Klaus Nickisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5733522
    Abstract: The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I ##STR1## in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR diagnosis and diagnostic radiology, especially for contrasting the hepatobiliary system. Further, the invention relates to a process for the production of these compounds and agents.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: March 31, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Heinz Gries, Bernd Raduchel, Orlin Petrov, Andreas Muhler, Thomas Frenzel, Hubert Vogler, Hans Bauer, Klaus Nickisch, Jean-Claude Hilscher
  • Patent number: 5712099
    Abstract: The invention relates to a process for the production of arabinonucleosides of general formula I ##STR1## in which X represents a hydrogen atom or a fluorine atom,from triacetates of general formula II ##STR2## in which X has the above-mentioned meaning, and the groupsAc respectively mean acetyl groups,which is characterized in that an esterase or lipase is caused to act on these compounds.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: January 27, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Heidi Hummel-Marquardt, Mario Kennecke, Alfred Weber, Thomas Schmitz, Ulf Tisltam, Klaus Nickisch
  • Patent number: 5654467
    Abstract: The invention relates to a process for the production of C-substituted diethylenetriamines of general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings.
    Type: Grant
    Filed: October 12, 1995
    Date of Patent: August 5, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Orlin Petrov, Jean-Claude Hilscher, Klaus Nickisch, Heribert Schmitt-Willich, Heinz Gries, Bernd Raduchel, Johannes Platzek
  • Patent number: 5569661
    Abstract: A new process for the production of .beta.-carbolines by dehydrogenation of tetrahydro-.beta.-carbolines with trichloroisocyanuric acid is described.
    Type: Grant
    Filed: June 23, 1995
    Date of Patent: October 29, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Klaus Nickisch
  • Patent number: 5523428
    Abstract: A process for the production of 1-methyl-3-keto-.DELTA..sup.1,4 steroids of general formula I ##STR1## in which St symbolizes the radical of asteroid molecule, where a 3-keto-.DELTA..sup.1,4 steroid of general formula II ##STR2## in which St has the above-mentioned meaning, is reacted in an inert solvent in the presence of a nickel salt soluble therein with an organometallic compound of formula III, IV or V ##STR3## where X, Y.sub.1, Y.sub.2, Y.sub.3, Z.sub.1 and Z.sub.2 are as defined in the specification.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: June 4, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Jurgen Westermann, Klaus Nickisch, Annette Prelle
  • Patent number: 5472854
    Abstract: A process for the production of 17-oxosteroids by fermentative oxidation of 17.beta.-hydroxy steroids is described, which is characterized in that for the fermentation, a bacterial culture of the species Mycobacterium spec. NRRL B-3805, Mycobacterium spec. NRRL B-3683, Mycobacterium phlei NRRL B-8154 or Mycobacterium fortuitum NRRL B-8153 is used.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: December 5, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Alfred Weber, Mario Kennekke, Uwe Klages, Klaus Nickisch, Ralph Rohde
  • Patent number: 5401854
    Abstract: A process for the production of indole derivatives, which is characterized in that in the presence of phosphoric acid a substitution with an imine is performed, and intermediate products of this process and the production of these intermediate products are described.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: March 28, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Helmut Borner, Wolfgang Kubler, Klaus Nickisch
  • Patent number: 5391778
    Abstract: The new intermediate products of general formula I ##STR1## in which R.sup.1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms,R.sup.2 stands for a hydrogen atom or a methyl group,R.sup.3 stands for a hydrogen atom,R.sup.4 stands for an acyloxy group with 1 to 4 carbon atoms in the acyl radical orR.sup.3 and R.sup.4 together stand for a keto-oxygen atom, are suitable in an excellent way for introducing a .DELTA..sup.1 double bond in the steroid skelton with the simultaneous presence of a .DELTA..sup.4 double bond, as well as a saturated carbonyl group, by clevage of hydrogen iodide with a base in an amidic solvent at elevated temperature. If R.sup.2 stands for a hydrogen atom, the A-ring is aromatized after the hydrogen iodide cleavage. For the production of a new intermediate products, special iodization processes, which partially also allow a stereoselective control of the iodization, are used.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: February 21, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Jurgen Westermann, Klaus Nickisch, Michael Harre, Ralph Rohde
  • Patent number: 5386028
    Abstract: A process for the production of N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetrade cane derivatives and their metal complexes is described.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: January 31, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulf Tilstam, Helmut Borner, Klaus Nickisch, Heinz Gries, Johannes Platzek
  • Patent number: 5371000
    Abstract: A process for the production of ergoline derivatives of general formula I is described ##STR1## in which the bonds represent two single-bonds or a double bond and a single bond.R.sub.1 means a hydrogen atom or an alkyl group with 1-6 carbon atomsR.sub.2 symbolizes a hydrogen atom or an alkyl group with 1-6 carbon atoms,R.sub.3 represents a carboxyl group or a grouping of formula--CONR.sub.4 R.sub.5 or --NHCQNR.sub.6 R.sub.7with R.sub.4 and R.sub.5 meaning hydrogen or an alkyl radical with 1-6 carbons atoms optionally substituted by a hydroxy group and R.sub.6 and R.sub.7 meaning an alkyl group containing 1-4 carbon atoms and Q meaning an oxygen or sulfur atom.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: December 6, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Heidi Hummel-Maquardt, Mario Kennecke, Alfred Weber, Klaus Nickisch, Gregor Haffer
  • Patent number: 5329009
    Abstract: Disclosed is chemoselective phenylation of 5-hydroxy-.beta.-carbolines in the presence of weak bases while adding water.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: July 12, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Helmut Borner, Klaus Nickisch, Julius Deutsch
  • Patent number: 5258290
    Abstract: A process for the production of .beta.-carboline derivatives of general formula I ##STR1## in which X represents a hydrogen atom or a halogen atom,Y represents a carbon-oxygen bond or a methyl group,R.sub.1 represents an alkyl group with up to 6 carbon atoms andR.sub.2 represents an alkyl group with up to 4 carbon atoms,from 1,2,3,4-tetrahydro-.beta.-carboline derivatives of general formula II ##STR2## in which X, Y, R.sub.1 and R.sub.2 have the above-mentioned meaning, is described, which is characterized in that the 1,2,3,4-tetrahydro-.beta.-carboline derivatives are fermented with a fungi culture of genus Fusarium or Myrothecium.
    Type: Grant
    Filed: July 9, 1992
    Date of Patent: November 2, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Alfred Weber, Mario Kennecke, Jean C. Hilscher, Klaus Nickisch
  • Patent number: 5198553
    Abstract: A process for the production of gramine derivatives is described, which is characterized in that an indole is reacted with an imine under acid catalysis in the presence of primary amines.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: March 30, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Kubler, Gregor Haffer, Reiner Wierzchowski, Klaus Nickisch
  • Patent number: 5051423
    Abstract: Novel derivatized alkanolamines of the following structural formula ##STR1## are described as useful cardiovascular agents. Most especially described is their usefulness as cardiovascular agents exhibiting an antiarrhythmic effect. Said antiarrhythmic effect is of a combination Class II/Class III variety. Pharmaceutical formulations containing such compounds are also described.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: September 24, 1991
    Assignee: Schering AG
    Inventors: Randall E. Lis, William C. Lumma, Jr., Thomas K. Morgan, Jr., Klaus Nickisch, Ronald A. Wohl
  • Patent number: 4920116
    Abstract: N-(aminoalkyl)-substituted(N or C alkyl)-aryl-4-(methylsylfonylamino)benzamides of the formula ##STR1## wherein R is C.sub.1 -C.sub.4 straight chain alkyl, one of R.sub.1, R.sub.2 and R.sub.3 is a phenyl or naphthyl group and the others are hydrogen, --NR.sub.4 R.sub.5 is a secondary or teritary amino group, X and X.sub.1 are hydrogen or alkyl and n is 0 or 1, are useful as antiarrhythmic agents in the treatment of cardiac arrhythmias especially as combination Class I/Class III agents.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: April 24, 1990
    Assignee: Schering A.G.
    Inventors: Thomas K. Morgan, Jr., Klaus Nickisch
  • Patent number: 4906634
    Abstract: Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: March 6, 1990
    Assignee: Schering A.G.
    Inventors: Stanley S. Greenberg, William C. Lumma, Jr., Klaus Nickisch, Ronald A. Wohl
  • Patent number: 4904462
    Abstract: Novel, multiple-tritiated steroid-20,17-spirolactones of general Formula I ##STR1## wherein --A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR2## and --C--D-- is ##STR3## R is hydrogen or tritium and n is 0 or 1,are usable as tracer materials for the detection of mineralocorticoid receptors.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: February 27, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Paul-Eberhard Schulze, Klaus Nickisch, Henry Laurent, Kunhard Pollow
  • Patent number: 4891365
    Abstract: 17-Substituted estradienes and estratrienes of Formula I ##STR1## wherein ##STR2## R is alkyl, alkenyl or cycloalkyl of up to 5 carbon atoms if ##STR3## R is hydrogen, alkyl, alkenyl or cycloalkyl of up to 5 carbon atoms if ##STR4## is a CC-single or CC-double bond, exhibit, an aldosterone-antagonistic activity and a strong gestagen potency.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: January 2, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Rudolf Wiechert, Sybille Beier, Walter Elger, Klaus Annen, Klaus Nickisch, Henry Laurent
  • Patent number: 4871482
    Abstract: 1-Methylandrosta-1,4-diene-3,17-dione is prepared by a process wherein a 3-enol ester or 3-enol ether of general Formula II ##STR1## wherein R.sub.1 is an alkyl residue of 1-3 carbon atoms or an acyl or trialkylsilyl group of up to 10 carbon atoms in the group, is converted into the 2-bromo steroid of Formular III ##STR2## wherein the bromine substituent can be in the .alpha.- as well as in the .beta.-position, and the compound of general Formula III is converted into 1-methylandrosta-1,4-diene-3,17-dione.
    Type: Grant
    Filed: May 6, 1988
    Date of Patent: October 3, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Klaus Nickisch, Hanfried Arnold
  • Patent number: 4868166
    Abstract: 2,2;6,6-diethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactones of general formula I, ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group,R.sub.2 represents a methyl or ethyl group and ##STR2## process for their production and their pharmaceutical use.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: September 19, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Bittler, Klaus Nickisch, Henry Laurent, Rudolf Wiechert, Martin Haberey