Patents by Inventor Klaus-Otto Minck
Klaus-Otto Minck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4870087Abstract: Indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --L--CH.sub.2 CH.sub.2 --, L is --S--, --SO-- or --SO.sub.2 --, and Th is a 2-- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.Type: GrantFiled: March 12, 1984Date of Patent: September 26, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Rudolf Gottschlich, Henning Bottcher, Hans-Heinrich Hausberg, Klaus-Otto Minck, Christoph Seyfried
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Patent number: 4829053Abstract: New aminoacid derivatives of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--NR.sup.6 --(CHR.sup.7).sub.s --D Iwherein X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, R.sup.6, R.sup.7, D, n and s have the meanings defined herein and their salts, inhibit the activity of human plasma renin.Type: GrantFiled: July 31, 1987Date of Patent: May 9, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Peter Raddatz, Joachim Gante, Claus J. Schmitges, Klaus Otto Minck, Johannes Sombroek, Gunter Holzemann
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Patent number: 4824852Abstract: New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 --or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,Z is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,is 2, 3, 4 or 5 andis 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts,have effects on the central nervous system.Type: GrantFiled: February 8, 1988Date of Patent: April 25, 1989Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Henning Bottcher, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4755592Abstract: New peptides of the formula IX--Z--W--E--W'--Y Iwherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.Type: GrantFiled: April 3, 1986Date of Patent: July 5, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus-Otto Minck, Hans-Eckart Radunz, Johannes Sombroek
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Patent number: 4740602Abstract: New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 -- or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,n is 2, 3, 4 or 5 andm is 1, 2 or 3,in which the alkyl groups each have 1-4 C atoms, and their salts, have effects on the central nervous system.Type: GrantFiled: June 26, 1986Date of Patent: April 26, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Henning Bottcher, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4698351Abstract: Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.Type: GrantFiled: August 22, 1986Date of Patent: October 6, 1987Assignee: Merck Patent Gesellschaft mit beschraenkter HaftungInventors: Hans-Heinrich Hausberg, Henning Bottch, Rudolf Gottschlich, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4654344Abstract: 2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CN.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologically acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.Type: GrantFiled: December 20, 1985Date of Patent: March 31, 1987Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Rochus Jonas, Michael Kloft, Hanns Wurziger, Juergen Harting, Hans J. Enenkel, Klaus-Otto Minck, Hans-Jochen Schliep
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Patent number: 4654350Abstract: Imidazo(4,5-c)pyridines of the formula ##STR1## wherein X is O, S or NH;Y is --NR.sup.2 --CH.dbd.N-- or --N.dbd.CH--NR.sup.2 --;R.sup.1 is 1-benzothienylmethyl, naphthylmethyl, or benzyl which is mono- or di-substituted by F, Cl, NO.sub.2, CF.sub.3 or a combination thereof, and;R.sup.2 is alkyl of 1-4 C atoms or cyclopropylmethyl,or a physiologically acceptable acid addition salt thereof,have valuable pharmacological activity, e.g., as GABA agonists.Type: GrantFiled: June 12, 1986Date of Patent: March 31, 1987Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Klaus Irmscher, Otto Saiko, Klaus-Otto Minck, Hans-Peter Wolf
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Patent number: 4618614Abstract: Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.Type: GrantFiled: January 15, 1986Date of Patent: October 21, 1986Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Heinrich Hausberg, Henning Bottcher, Rudolf Gottschlich, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4617309Abstract: Sulfur-containing indole derivatives of the general formula I ##STR1## wherein Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN by a methylenedioxy group, A is --(CH.sub.2).sub.n --E--C.sub.m H.sub.2m -- or --(CH.sub.2).sub.n --E--C.sub.m-1 H.sub.2m-2 CO--, n is 0 or 1, m is 2, 3 or 4, E is S, SO or SO.sub.2 and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group and wherein the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.Type: GrantFiled: September 30, 1983Date of Patent: October 14, 1986Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Henning Bottcher, Rudolf Gottschlich, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4575505Abstract: 2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CH.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or trisubstituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologially acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.Type: GrantFiled: July 26, 1984Date of Patent: March 11, 1986Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rochus Jonas, Michael Kloft, Hanns Wurziger, Jurgen Harting, Hans J. Enenkel, Klaus-Otto Minck, Hans-Jochen Schliep
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Patent number: 4547576Abstract: Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.Type: GrantFiled: January 4, 1984Date of Patent: October 15, 1985Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Heinrich Hausberg, Henning Bottcher, Rudolf Gottschlich, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4500541Abstract: Cyclopropane derivatives of the formula ##STR1## wherein Ar is phenyl or phenyl monosubstituted or polysubstituted by F, Cl, Br, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkenyloxy, C.sub.1-4 alkylthio, OH, SH, CN, methylenedioxy or CF.sub.3 ; and R is H, C.sub.1-4 alkyl or benzyl, or a physiologically acceptable acid addition salt thereof, have valuable pharmacological properties, e.g., as antidepressants.Type: GrantFiled: June 17, 1983Date of Patent: February 19, 1985Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Hans-Heinrich Hausberg, Jurgen Uhl, Christoph Seyfried, Klaus-Otto Minck
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Patent number: 4477454Abstract: 2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CH.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologically acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.Type: GrantFiled: May 9, 1983Date of Patent: October 16, 1984Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Rochus Jonas, Michael Kloft, Hanns Wurziger, Juergen Harting, Hans J. Enenkel, Klaus-Otto Minck, Hans-Jochen Schliep
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Patent number: 4225608Abstract: Phenoxyalkylamines of the formulaAr--O--Rwherein Ar is phenyl or phenyl which is monosubstituted or disubstituted by F, Cl, Br, alkyl or alkoxy each of 1-4 carbon atoms, cycloalkoxy of 3-6 carbon atoms, CF.sub.3, CN, alkylthio of 1-4 carbon atoms, SCF.sub.3, OH and/or alkanoyloxy with 1-10 carbon atoms; R is (1-R.sup.1 -2-pyrrolidyl)--CH.sub.2 --CHR.sup.2 --, (1-R.sup.1 -2-piperidyl)-CH.sub.2 --CHR.sup.2 -- or 1-R.sup.1 -3-Z-4-hexahydroazepinyl; R.sup.1 is H, alkyl or alkenyl each of up to 4 carbon atoms, cyclopropylmethyl or benzyl; R.sup.2 is H, alkyl of 1-4 carbon atoms or phenyl; and Z is alkyl of 1-4 carbon atoms with the proviso that Ar is p-fluorophenyl only if R is not 2-(1-methyl-2-piperidyl)-ethyl; and the physiologically acceptable acid addition salts thereof, possess valuable pharmacological properties, e.g., are antidepressants.Type: GrantFiled: March 16, 1979Date of Patent: September 30, 1980Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Jurgen Uhl, Dieter Marx, Hans-Heinrich Hausberg, Wighard Strehlow, Klaus-Otto Minck, Helmut Muller-Calgan, Christoph Seyfried