Abstract: The present invention relates to the use of EZH2 inhibitors for the treatment of psoriasis, a pharmaceutical composition for the treatment of psoriasis comprising said EZH2 inhibitors, a method for the preparation of said pharmaceutical composition, a method for the therapeutic treatment of a living being against psoriasis, a method for the screening of active agents against psoriasis, and the use in vitro of a EZH2 inhibitor for the suppression of the cellular I?B? expression.

Abstract: The present invention relates to the use of CDK4/6 inhibitors for the treatment of psoriasis, a pharmaceutical composition for the treatment of psoriasis comprising said CDK4/6 inhibitors, a method for the preparation of said pharmaceutical composition, a method for the therapeutic treatment of a living being against psoriasis, a method for the screening of active agents against psoriasis, and the use in vitro of a CDK4/6 inhibitor for the suppression of the cellular I?B? expression.

Abstract: The present invention relates to novel compounds useful for visualizing cell senescence in vitro and in vivo, the preparation of said compounds and their use. In particular, the present invention pertains to novel hexose and particularly galactose derivatives which are useful as senescence tracers in vitro and in vivo.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: The instant invention relates to novel compounds useful for visualizing cell senescence, their preparation and use. In particular, this invention relates to novel fucose and amino-quinoline derivatives useful as senescence traces and their preparation.

Abstract: A method for determining the sharpness of cutting edges (16) of chopper blades (1) at a rotationally driven chopper drum (14) of a forage harvester includes scanning a blade surface of at least one of the chopper blades located behind the cutting edge by at least one electrode operating as a contact sensor and determining a duration of contact of the at least one electrode with the blade surface.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: The invention relates to a gas flow monitor wherein the closing flow has the same value in a plurality of installation positions. According to the invention, the gas flow monitor is further intended to be suitable for small pressure loss values. Design and production are intended to be as simple as possible. The gas flow monitor according to the invention, comprising a gas-tight housing (1) that has a valve seat (4) for an axially movable closing body (10) in the interior that to is held against the direction of flow in the opening position by spring force, is characterized in that the play of said mounting is greater in the open position and continuously narrows upon beginning the closing movement.

Abstract: A method of feeding is described. The method comprises feeding a mono-gastric animal with a feed, wherein said feed comprises a phytase, wherein said phytase results in an improvement in one or more of said animal's biophysical characteristics, especially when compared to the equivalent use of Peniophora lycii phytase and/or an E. coli phytase. In particular, the method results in an improvement in said animal's biophysical characteristics as a food source.

Abstract: The instant invention relates to novel compounds useful for visualizing cell senescence, their preparation and use. In particular, this invention relates to novel fucose and aminoquinoline derivatives useful as senescence traces and their preparation.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: Provided herein are improved variants of polypeptides having cellobiohydrolase II activity, nucleic acids encoding the polypeptides, vectors, host cells containing the nucleic acids and methods for producing the polypeptides. The polypeptides encompassed by this disclosure may be used in numerous applications including the use of the polypeptides for the production of biofuels and for the synthesis of platform chemicals or biopolymers from renewable sources.

Abstract: A method for determining the sharpness of cutting edges (16) of chopper blades (1) at a rotationally driven chopper drum (14) of a forage harvester includes scanning a blade surface of at least one of the chopper blades located behind the cutting edge by at least one electrode operating as a contact sensor and determining a duration of contact of the at least one electrode with the blade surface.

Abstract: The invention relates to a gas flow monitor wherein the closing flow has the same value in a plurality of installation positions. According to the invention, the gas flow monitor is further intended to be suitable for small pressure loss values. Design and production are intended to be as simple as possible. The gas flow monitor according to the invention, comprising a gas-tight housing (1) that has a valve seat (4) for an axially movable closing body (10) in the interior that to is held against the direction of flow in the opening position by spring force, is characterised in that the play of said mounting is greater in the open position and continuously narrows upon beginning the closing movement.

Abstract: Provided herein are improved variants of polypeptides having cellobiohydrolase II activity, nucleic acids encoding the polypeptides, vectors, host cells containing the nucleic acids and methods for producing the polypeptides. The polypeptides encompassed by this disclosure may be used in numerous applications including the use of the polypeptides for the production of biofuels and for the synthesis of platform chemicals or biopolymers from renewable sources.

Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.

Abstract: A method for the detection of apoptosis by determining presence, amount, or activity of apoptosis-specific markers released from at least one cell undergoing apoptosis into an extracellular medium through cellular release mechanisms is disclosed. The extracellular medium includes body fluids, in particular urine, inflammatory fluid, serum, liquor, or cell culture medium, wherein samples are preferably taken from humans or animals. The method can be used for the diagnosis and/or for therapy control of diseases and/or processes associated with increased apoptosis. It can also be used for therapy control of diseases associated with decreased apoptosis. Additionally, a method is disclosed for the identification of apoptosis-modulating substances, characterized in that apoptosis-specific markers released from a cell culture sample into an extracellular cell culture medium through cellular release mechanisms are determined.

Abstract: This invention relates to compositions for inhibiting apoptosis, containing one to all components of: (a) an APO-1-inhibiting compound; (b) a compound inhibiting and catching, respectively, the APO-1 ligand; and (c) a compound inhibiting the intracellular APO-1 signalling pathway, the component(s) being not considered foreign in an individual, as well as conventional excipients. Furthermore, this invention relates to compounds suitable for inhibiting apoptosis and having at least one extracellular APO-1 domain and a carrier, the domain(s) and the carrier being not considered foreign in an individual.