Patents by Inventor Koen Johan Herman Weerts

Koen Johan Herman Weerts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallization procedure for obtaining canagliflozin hemihydrate crystals
    Patent number: 10323025
    Abstract: The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: June 18, 2019
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ruben De Keyser, Stijn Laps, Thomas Joachim Landewald Rammeloo, Koen Johan Herman Weerts
  • CRYSTALLIZATION PROCEDURE FOR OBTAINING CANAGLIFLOZIN HEMIHYDRATE CRYSTALS
    Publication number: 20190002449
    Abstract: The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 3, 2019
    Applicant: Janssen Pharmaceutica NV
    Inventors: Ruben De Keyser, Stijn Laps, Thomas Joachim Landewald Rammeloo, Koen Johan Herman Weerts
  • PROCESS FOR THE PREPARATION OF HETEROCYCLIC ESTER DERIVATIVES
    Publication number: 20160168170
    Abstract: The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I wherein A1, SEM, and W1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Application
    Filed: February 23, 2016
    Publication date: June 16, 2016
    Inventors: Jean-Pierre Andre Marc BONGARTZ, Alfred Elisabeth STAPPERS, Christopher A. TELEHA, Koen Johan Herman WEERTS, Kenneth J. WILSON
  • Process for the preparation of heterocyclic ester derivatives
    Patent number: 9303046
    Abstract: The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I wherein A1, SEM, and W1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: April 5, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean-Pierre André Marc Bongartz, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts, Kenneth J. Wilson
  • Process for the preparation of C-FMS kinase inhibitors
    Patent number: 9029352
    Abstract: The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: May 12, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Krzysztof Kolodziejczyk, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts
  • PROCESS FOR THE PREPARATION OF HETEROCYCLIC ESTER DERIVATIVES
    Publication number: 20140046072
    Abstract: The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I wherein A1, SEM, and W1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Application
    Filed: August 5, 2013
    Publication date: February 13, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Jean-Pierre André Marc BONGARTZ, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts, Kenneth J. Wilson
  • PROCESS FOR THE PREPARATION OF C-FMS KINASE INHIBITORS
    Publication number: 20140045789
    Abstract: The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.
    Type: Application
    Filed: August 5, 2013
    Publication date: February 13, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Krzysztof KOLODZIEJCZYK, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts