Patents by Inventor Koh-ei Toyoshima

Koh-ei Toyoshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190201579
    Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.
    Type: Application
    Filed: June 19, 2017
    Publication date: July 4, 2019
    Applicants: Organ Technologies, Inc., Riken
    Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA, Miho OGAWA
  • Publication number: 20190170726
    Abstract: The purpose of the present invention is to propose a method for measuring the level of health of a subject, with which it is possible: to perform health examination that is non-invasive to the human body and that employs a simple method; to provide highly reliable analysis results having a scientific basis; and to, additionally, provide appropriate solutions to the subject. Another purpose of the present invention is to propose a health-level determining apparatus employing said method and a new business model employing said method. The present invention is a method for measuring the level of health of a subject, including a hair analyzing step (A) for analyzing hair of the subject. It is preferable that the aforementioned hair analyzing step (A) include a step (A-1) for analyzing hair in the occipital region. In addition, it is preferable that the aforementioned hair analyzing step (A) include a step (A-2) for analyzing hair in a site other than the occipital region.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 6, 2019
    Applicants: ORGAN TECHNOLOGIES INC., RIKEN
    Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA
  • Publication number: 20180355315
    Abstract: To provide a method of efficiently producing full thickness skin having skin accessory organs. [Solution] This method of producing full thickness skin having skin accessory organs is characterized by involving the following steps (a) to (d): (a) a step for stimulating an embryoid body with a physiologically active substance that can activate the Wnt pathway, (b) a step for preparing a conjugate that includes all or part of the embryoid body stimulated in step (a) and a scaffolding material, (c) a step for transplanting the conjugate prepared in step (b) into an animal, and (d) a step for producing, in the animal, full thickness skin derived from said conjugate.
    Type: Application
    Filed: September 7, 2015
    Publication date: December 13, 2018
    Applicant: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Koh-ei Toyoshima
  • Patent number: 9982238
    Abstract: A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: May 29, 2018
    Assignee: Organ Technologies, Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Patent number: 9321998
    Abstract: A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 26, 2016
    Assignee: Organ Technologies Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Publication number: 20140052167
    Abstract: A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.
    Type: Application
    Filed: February 21, 2012
    Publication date: February 20, 2014
    Applicant: ORGAN TECHNOLOGIES INC.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Publication number: 20140037592
    Abstract: A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
    Type: Application
    Filed: July 7, 2011
    Publication date: February 6, 2014
    Applicant: Organ Technologies Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji