Patents by Inventor Koichi Araki
Koichi Araki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092890Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.Type: ApplicationFiled: August 26, 2021Publication date: March 21, 2024Applicants: JUNTENDO EDUCATIONAL FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.Inventors: Norio KOMATSU, Marito ARAKI, Yoshihiko KIHARA, Yoji ISHIDA, Koichi KITAMURA, Takayoshi FUKUSHIMA, Kaori YASUI
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Patent number: 11911945Abstract: Provided are an injection molding machine and an injection molding method. An injection molding machine includes: a plasticizing unit which rotates a screw to plasticize a molding material inside a plastication cylinder, and an injection unit. The injection unit has: a plunger reciprocally moving inside an injection chamber, and an injection driving device reciprocally moving the plunger. By driving the injection driving device to move the plunger backward and forward inside the injection chamber, and driving a rotary driving device to alternately rotate the screw in a normal rotation direction and a reverse rotation direction, the molding material is controlled to reciprocate between the plastication cylinder and the injection chamber.Type: GrantFiled: July 19, 2021Date of Patent: February 27, 2024Assignee: Sodick Co., Ltd.Inventors: Yoshikazu Kubo, Hisakazu Araki, Koichi Hirota, Kenzo Akiyama
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Publication number: 20220330550Abstract: Provided is a compound useful as an active ingredient of an agricultural and horticultural chemical agent, in particular, an agricultural and horticultural pest control agent such as an agricultural and horticultural insecticide or an agricultural and horticultural mite control agent. The compound is an imidazopyridine-2-carboxamide derivative or its N-oxide or salt represented by the following formula (1): in the formula, R1 and R2 are, for example, C1-3 alkyl groups, X is, for example, an oxygen atom or a sulfur atom, A1, A2, A3, A4, and A5 are each independently a nitrogen atom or C—R3, R3 is, for example, a hydrogen atom or a C1-3 haloalkyl group, and R4 is, for example, a C1-3 alkyl group or a C1-3 haloalkyl group.Type: ApplicationFiled: June 12, 2020Publication date: October 20, 2022Applicant: AGRO-KANESHO CO., LTD.Inventors: Katsuaki OYAMA, Kohei OJIMA, Koichi ARAKI, Saki MORISHITA, Toshiki FUKUCHI
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Patent number: 10513496Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.Type: GrantFiled: March 28, 2018Date of Patent: December 24, 2019Assignee: Bayer Animal Health GmbHInventors: Ulrich Görgens, Akihiko Yanagi, Katsuaki Wada, Tetsuya Murata, Yukiyoshi Watanabe, Jun Mihara, Koichi Araki
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Patent number: 10442768Abstract: The present invention provides a method for producing a 2-aminonicotinic acid benzyl ester derivative. The method includes, as a step, reacting a 2-aminonicotinic acid derivative represented by the formula [I], wherein R1 represents a hydrogen atom or a C1 to C4 alkyl group and M represents an alkali metal, with a benzyl derivative represented by the formula [II], wherein R2 represents, for example, a hydrogen atom or a halogen atom, A represents, for example, a nitrogen atom, X represents a halogen atom, and Y represents, for example, an oxygen atom, in an aromatic hydrocarbon solvent in the presence of a phase transfer catalyst or a tertiary amine.Type: GrantFiled: November 8, 2016Date of Patent: October 15, 2019Assignee: AGRO-KANESHO CO., LTD.Inventors: Ryo Aizawa, Koichi Araki
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Publication number: 20180362464Abstract: The present invention provides a method for producing a 2-aminonicotinic acid benzyl ester derivative. The method includes, as a step, reacting a 2-aminonicotinic acid derivative represented by the formula [I], wherein R1 represents a hydrogen atom or a C1 to C4 alkyl group and M represents an alkali metal, with a benzyl derivative represented by the formula [II], wherein R2 represents, for example, a hydrogen atom or a halogen atom, A represents, for example, a nitrogen atom, X represents a halogen atom, and Y represents, for example, an oxygen atom, in an aromatic hydrocarbon solvent in the presence of a phase transfer catalyst or a tertiary amine.Type: ApplicationFiled: November 8, 2016Publication date: December 20, 2018Applicant: AGRO-KANESHO CO., LTD.Inventors: Ryo AIZAWA, Koichi ARAKI
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Publication number: 20180215713Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.Type: ApplicationFiled: March 28, 2018Publication date: August 2, 2018Inventors: Ulrich GÖRGENS, Akihiko YANAGI, Katsuaki WADA, Tetsuya MURATA, Yukiyoshi WATANABE, Jun MIHARA, Koichi ARAKI
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Patent number: 9944604Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.Type: GrantFiled: April 26, 2012Date of Patent: April 17, 2018Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Ulrich Görgens, Akihiko Yanagi, Kazue Yanagi, Keisuke Yanagi, Kasumi Yanagi, Katsuaki Wada, Tetsuya Murata, Yukiyoshi Watanabe, Jun Mihara, Koichi Araki
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Patent number: 9902697Abstract: The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III]with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I].Type: GrantFiled: June 27, 2014Date of Patent: February 27, 2018Assignee: AGRO-KANESHO CO., LTD.Inventors: Ryo Aizawa, Koichi Araki
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Patent number: 9714223Abstract: The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III]with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I].Type: GrantFiled: June 27, 2014Date of Patent: July 25, 2017Assignee: AGRO-KANESHO CO., LTD.Inventors: Ryo Aizawa, Koichi Araki
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Publication number: 20170129858Abstract: The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III]with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I].Type: ApplicationFiled: June 27, 2014Publication date: May 11, 2017Applicant: AGRO-KANESHO CO., LTD.Inventors: Ryo AIZAWA, Koichi ARAKI
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Publication number: 20160324834Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.Type: ApplicationFiled: May 16, 2016Publication date: November 10, 2016Inventors: Rafi R. Ahmed, Christian P. Larsen, Koichi Araki
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Patent number: 9375000Abstract: Arylpyrrolidines of Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite-controlling agents.Type: GrantFiled: September 13, 2011Date of Patent: June 28, 2016Assignee: Bayer Intellectual Property GmbHInventors: Jun Mihara, Mamoru Hatazawa, Daiei Yamazaki, Hidetoshi Kishikawa, Kei Domon, Hidekazu Watanabe, Norio Sasaki, Tetsuya Murata, Koichi Araki, Eiichi Shimojo, Teruyuki Ichihara, Tadashi Ishikawa, Katsuhiko Shibuya, Ulrich Görgens, Peter Bruechner, Reiner Fischer, Johannes-Rudolf Jansen, Tobias Kapferer, Simon Maechling, Michael Maue, Arnd Voerste
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Patent number: 9271499Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: GrantFiled: July 3, 2014Date of Patent: March 1, 2016Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
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Patent number: 9266830Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: GrantFiled: July 21, 2014Date of Patent: February 23, 2016Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
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Patent number: 9227923Abstract: The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite controlling agents.Type: GrantFiled: August 3, 2010Date of Patent: January 5, 2016Assignee: Bayer Intellectual Property GmbHInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Yukiyoshi Watanabe, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Gorgens
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Publication number: 20150073139Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: ApplicationFiled: July 21, 2014Publication date: March 12, 2015Inventors: Ulrich GÖRGENS, Jun MIHARA, Tetsuya MURATA, Daiei YAMAZAKI, Yasushi YONETA, Koichi ARAKI, Norio SASAKI, Kei DOMON, Mamoru HATAZAWA, Eiichi SHIMOJO, Teruyuki ICHIHARA, Masashi ATAKA, Katsuhiko SHIBUYA
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Publication number: 20150011553Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: ApplicationFiled: July 3, 2014Publication date: January 8, 2015Inventors: Ulrich GÖRGENS, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
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Patent number: 8927458Abstract: Triazolylpyridine ketones expressed by the following formula (1) and use thereof as herbicides.Type: GrantFiled: May 22, 2013Date of Patent: January 6, 2015Assignee: Bayer CropScience AGInventors: Andreas Van Almsick, Shinichi Narabu, Yoshitaka Sato, Kei Domon, Koichi Araki, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Chieko Ueno
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Publication number: 20140370059Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.Type: ApplicationFiled: August 25, 2014Publication date: December 18, 2014Inventors: Rafi R. Ahmed, Christian P. Larsen, Koichi Araki