Patents by Inventor Koichi Hirai

Koichi Hirai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5399711
    Abstract: Two thiomarinol derivatives, which have antibacterial and anti-mycoplasmal properties, are obtainable from microorganisms of the genus Alteromonas and are named "thiomarinol B" and "thiomarinol C". Thiomarinol B can also be prepared by the oxidation of thiomarinol.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: March 21, 1995
    Assignee: Sankyo Company, Limited
    Inventors: Shuji Takahashi, Hideyuki Shiozawa, Katsumi Fujimoto, Yuji Iwano, Koichi Hirai, Akio Torikata, Takeshi Kagasaki, Kaneo Ogawa, Yoshiharu Sakaida, Kentaro Kodama, Akira Ishii
  • Patent number: 5028610
    Abstract: Compounds of formula (I):A--M--B-- (I)(in which: M represents a saturated heterocyclic group having from 5 to 7 ring atoms of which 2 are nitrogen atoms, said group being unsubstituted or being substituted at any of its carbon atoms by C.sub.1 -C.sub.6 alkyl and/or oxo substituents: A represents a halo-substituted benzhydryl substituent; and B represents certain specific substituted alkyl groups) and salts thereof are valuable for the treatment and prophylaxis of disorders arising from circulatory problems, especially those affecting the brain. They may be prepared by reacting a compound of formula A--M--H with a halo or acyloxy derivative corresponding to the alkyl substituent B which it is desired to introduce.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: July 2, 1991
    Assignee: Sankyo Company Limited
    Inventors: Koichi Hirai, Yuji Iwano, Katsumi Fujimoto, Yoshiki Matsui
  • Patent number: 4957537
    Abstract: The present invention discloses a new plant growth regulating composition which comprises, as an active ingredient, a selected succinamide compounds, maleimide compounds, succinic anhydride compounds, maleic anhydride compounds of general formula: ##STR1## if preferably, along with ethephon. In this invention, the plant growth regulating composition has the effect of plant growth controlling activity (herbicidal activity) and an abscission layer forming activity for a fruit harvest aid, and the said plant growth regulating composition does not cause hazards such as defoliation and injuries to the fruit surface, nor does it affect immature fruit, but acts specifically on matured fruit and promptes formation of abscission layer that aids in the separation of matured fruit.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: September 18, 1990
    Assignees: Fujisawa Pharmaceutical Company, Ltd, Nissan Chemical Industries, Ltd.
    Inventors: Tsutomu Teraji, Atsushi Yamamura, Yasuo Kamuro, Koichi Hirai, Seiichi Fujii
  • Patent number: 4647551
    Abstract: A hydrogenation catalyst composition useful for the hydrogenation of an oxalate diester, said composition being composed of a reduction product of a copper-containing silica gel formed by contacting an amine complex of copper with silica gel having an average particle diameter of not more than 200.mu. and a process for producing the aforesaid composition. Using a catalyst composed of the aforesaid composition, ethylene glycol and/or a glycolic acid ester can be produced from an oxalate diester efficiently with high conversions and selectivities and without causing pollution attributed to the use of a chromium-containing catalyst composition.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: March 3, 1987
    Assignee: Ube Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Koichi Hirai, Taizo Uda, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4619685
    Abstract: A plant growth regulator comprising, as the active substance, one or more of N-substituted alanine derivatives of the general formula: ##STR1## wherein X represents halogen atom or trifluoromethyl, R represents hydrogen, straight chain or branched chain alkyl having 1-4 carbon atoms, alkenyl having 2-4 carbon atoms, an alkali metal atom or amine-forming residue, and n is zero or an integer of 1 or 2, with the proviso that when n is 2, X may be same or different, together with an inert carrier or diluent, in particular, an agent effective for controlling suckers of tobacco, and a process for regulating plant growth by using said plant growth regulator.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: October 28, 1986
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Yasuo Kamuro, Koichi Hirai, Fumio Suzuki, Susumu Yamamoto, Noboru Shindo
  • Patent number: 4617367
    Abstract: A methyl methacrylate syrup composition comprises an intimate mixture of 1-99 parts by weight of a first polymer-in-monomer syrup (A) and 99-1 parts by weight of a second polymer-in-monomer syrup which can be either (B.sub.1) or (B.sub.2), wherein the syrups (A), (B.sub.1) and (B.sub.2) are as follows:(A) a polymer-in-monomer syrup obtained by copolymerizing a mixture of methyl methacrylate monomer, one or more monomers having reactivity with glycidyl groups and containing at least one ethylenically-unsaturated bond, and one or more of (meth)acrylates, styrene and styrene derivatives;(B.sub.1) a polymer-in-monomer syrup obtained by copolymerizing a mixture of one or more monomers containing at least one glycidyl group and at least one ethylenically-unsaturated bond, and one or more monomers selected from the group consisting of methyl methacrylate, (meth)acrylates, styrene and styrene derivatives;(B.sub.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: October 14, 1986
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Katsushi Watanabe, Takafumi Kageyama, Taisaku Kano, Koichi Hirai, Yoshinobu Ichihara
  • Patent number: 4614728
    Abstract: A hydrogenation catalyst composition composed of a reduction product of a copper-containing material formed by contacting an aqueous solution of an amine/copper complex with a carrier, characterized in that the carrier is a hydrolyzed product obtained by hydrolyzing a silicate ester in the presence of ammonia; a process for producing the aforesaid hydrogenation catalyst composition; and a process for producing ethylene glycol or a glycolate ester in the presence of the aforesaid hydrogenation catalyst.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: September 30, 1986
    Assignee: Ube Industries, Ltd.
    Inventors: Koichi Hirai, Taizo Uda, Yasuo Nakamura
  • Patent number: 4585890
    Abstract: A hydrogenation catalyst composition useful for the hydrogenation of an oxalate diester, said composition being composed of a reduction product of copper-containing silica gel formed by contacting an ammine complex of copper with colloidal silica sol; and a process for producing the aforesaid composition. Using a catalyst composed of the aforesaid composition, ethylene glycol and/or a glycolic acid ester can be produced from an oxalate diester efficiently with high conversions and selectivities and without causing pollution attributed to the use of a chromium-containing catalyst composition.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: April 29, 1986
    Assignee: UBE Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Taizo Uda, Koichi Hirai, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4551565
    Abstract: In a process for producing ethylene glycol and/or a glycollic acid ester by the vapor phase catalytic hydrogenation of an oxalic acid diester in the presence of a catalyst and hydrogen gas, the improvement wherein the catalyst has the following composition formulaCuMo.sub.k Ba.sub.p O.sub.qwherein k, p and q represent gram-atoms of Mo, Ba and O, respectively, per gram-atom of Cu, k is a number of from 0 to 3, p is a number of from 0 to 6, and q is a number determined depending upon the atomic valence and gram-atoms of Cu, Mo and Ba, provided that k and p are not zero at the same time; and the aforesaid catalyst.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: November 5, 1985
    Assignee: UBE Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Koichi Hirai, Taizo Uda, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4545942
    Abstract: New compounds useful as immunoregulatory and antineoplastic agents are amino-acid derivatives of formula: ##STR1## wherein: n is an integer from 1 to 5;R.sup.1 is a hydrogen atom, an alkyl group, a haloalkyl group, a halogen atom, a mercapto group, an alkylmercapto group, a hydroxy group, an alkoxy group, an acyloxy group, a carboxyl group, an alkoxycarbonyl group, an amino group, an alkyl-substituted amino group, an aryl-substituted amino group, an acylamino group, a haloalkoxycarbonylamino group, an alkanesulphonyl group, a nitro group or a cyano group (and, when n is an integer from 2 to 5, the radicals R.sup.1 may be the same or different);R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or an alkyl group;R.sup.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: October 8, 1985
    Assignee: Sankyo Company, Limited
    Inventors: Mitsuo Nagano, Koichi Hirai, Kouichi Kitamura, Kenkichi Shinkai, Hiroshi Yasuda
  • Patent number: 4511744
    Abstract: A hydrogenation catalyst composition for use in the hydrogenation of a lower alkyl ester of a lower hydroxycarboxylic acid. The composition is composed of a reduction product of copper-containing silica gel formed by contacting an ammine complex of copper with silica gel having an average particle diameter of not more than 200 microns or colloidal silica sol. A process for producing the catalyst composition is also provided. By using the aforesaid catalyst composition, a lower alkylene glycol can be produced efficiently in high conversions and selectivities without causing pollution attributed to the use of a chromium-containing catalyst composition.
    Type: Grant
    Filed: May 5, 1983
    Date of Patent: April 16, 1985
    Assignee: UISE Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Koichi Hirai, Taizo Uda, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4440873
    Abstract: A hydrogenation catalyst composition useful for the hydrogenation of an oxalate diester, said composition being composed of a reduction product of copper-containing silica gel formed by contacting an amine complex of copper with colloidal silica sol; and a process for producing the aforesaid composition. Using a catalyst composed of the aforesaid composition, ethylene glycol and/or a glycolic acid ester can be produced from an oxalate diester efficiently with high conversions and selectivities and without causing pollution attributed to the use of a chromium-containing catalyst composition.
    Type: Grant
    Filed: April 21, 1982
    Date of Patent: April 3, 1984
    Assignee: UBE Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Taizo Uda, Koichi Hirai, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4409395
    Abstract: In a process for producing a glycollic acid ester by the vapor phase catalytic hydrogenation of an oxalic acid diester in the presence of a catalyst and hydrogen gas, the improvement wherein the oxalic acid diester in the vaporous state is contacted with hydrogen gas in the presence of a catalyst composed of Ag or Pd supported on a solid carrier at a temperature of from about 120.degree. C. to about 300.degree. C.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: October 11, 1983
    Assignee: UBE Industries, Ltd.
    Inventors: Haruhiko Miyazaki, Koichi Hirai, Taizo Uda, Yasuo Nakamura, Harumi Ikezawa, Takanori Tsuchie
  • Patent number: 4064137
    Abstract: Novel penicillin and cephalosporin derivatives possessing interferon inducibility and represented by the formula ##STR1## wherein Y represents a hydrogen atom, a halogen atom a nitro group, an alkoxy group or an alkyl group; M represents a protective group for a hydroxyl or carboxyl group; Z represents a group ##STR2## or a group ##STR3## in which D is a hydrogen atom, an acyloxy group, a carbamoyloxy group or a substituted or unsubstituted heterocyclic thio group; A represents a cyano group, a carboalkoxy group or a nitro group; and B represents a hydrogen atom, a cyano group, a carboalkoxy group or a nitro groupAnd process for preparing the same.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: December 20, 1977
    Assignee: Sankyo Company Limited
    Inventors: Koichi Hirai, Yuji Iwano, Tokio Saito, Tetsuo Hiraoka, Yukichi Kishida, Takuzo Nishimura