Abstract: A method of increasing platelets in mammals which comprises administering to mammals an effective amount of a heparin-binding secretory transforming factor 1 protein (hst-1) having an N-terminal deletion of 27 amino acids.

Abstract: A monoclonal antibody is produced from a cloned hybridoma, and the monoclonal antibody combines specifically with basic fibroblast growth factor (bFGF). Therefore, the monoclonal antibody can be advantageously used for assay reagents on bFGF or for purification of bFGF.

Abstract: Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.

Abstract: The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

Abstract: An expression vector comprises a cDNA sequence encoding an aFGF protein and a T7 promoter upstream therefrom. The vector is useful for transforming host cells and expressing the aFGF gene.

Abstract: Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.

Abstract: In accordance with the present invention, there are provided information recording media having a substrate and thereon a recording layer and a metallic layer, wherein the metallic layer is composed of an aluminum alloy containing (i) titanium and (ii) at least one metal selected from among chromium, niobium and magnesium. The information recording media thus provided are excellent in corrosion resistance and small in dependence of the recording power on linear velocity.

Abstract: Lymphotoxin (LT) mutein (genetically-altered LT) is disclosed that has the following amino acid sequence, or a portion of an active portion of said protein, where 10 to 21 amino acids of LT being deleted from N-terminus and which has Pro or Phe at the N-terminus: ##STR1## Wherein R.sub.1 is Pro or Phe, R.sub.2 is a peptide chain represented by the following sequence:Ala-Gln-Thr-Ala-Arg-Gln-His-Pro-Lys-Met-His-Leu,or a portion thereof and n is 0 or 1.The LT mutein can be recovered in a higher yield and purified more efficiently under mild conditions which does not harm the LT's biological activity, than the whole LT.

Abstract: In accordance with the present invention, there are provided information recording media having a substrate and thereon a recording layer and a metallic layer, wherein the metallic layer is composed of an aluminum alloy containing (i) titanium and (ii) at least one metal selected from among chromium, niobium and magnesium. The information recording media thus provided are excellent in corrosion resistance and small in dependence of the recording power on linear velocity.

Abstract: In accordance with the present invention, there are provided information recording media having a substrate and thereon a recording layer, and a metallic layer composed of an aluminum alloy containing at least hafnium. The information recording media provided are excellent in corrosion resistance and also small in dependence of the recording power on linear velocity.

Abstract: An animal cell line transformed with an expression vector for an animal cell, the expression vector which contains a DNA segment comprising:(a) a DNA sequence coding for a signal peptide of an animal cell-derived protein,(b) a second DNA sequence coding for a different protein from the signal protein joined downstream of said signal peptide encoding DNA sequence without causing any reading frame shift, and(c) a promoter DNA sequence capable of functioning in an animal cell, wherein the promoter sequence is positioned upstream of the signal peptide encoding DNA sequence, can produce glycosylated proteins advantageously as secretable proteins.

Abstract: A magnetic bubble memory element comprising a magnetic bubble memory unit and a separating region portion, which is prepared by the steps of forming a plurality of island shaped magnetic bubble memory units with separating regions intervening therebetween on a single crystalline substrate and performing the cutting process along the separating regions. In a preferably prepared memory element, the magnetic bubble memory unit and the separating region portion own in common a single crystalline magnetic thin layer which is formed on the substrate and the memory unit further comprises a hard bubble suppression film deposited on the magnetic thin layer, a conductor pattern layer and a magnetic film pattern layer both of which are deposited in that order on the suppression film so as to be insulated therefrom as well as insulated from each other.

Abstract: There is disclosed a method wherein sulfur dioxide contained in combustion exhaust gas is absorbed in an aqueous alkali sulfite solution to produce a corresponding alkali bisulfite and the resultant aqueous alkali bisulfite solution is added with calcium carbonate to form calcium sulfite, the method comprising wet-powdering the calcium carbonate into a particle size within a range of 0.1 - 30 .mu. in a slurry form by the use of a part of a filtrate which is obtained by separating calcium sulfite from the reaction solution, and re-using the remainder of the filtrate as an aqueous alkali sulfite solution for absorbing sulfur dioxide, whereby substantially no waste water is discharged out of the reaction system and sulfur dioxide can be recovered in the form of highly pure calcium sulfite.