Abstract: Provided is an orally administrable vaccine against a coronavirus infectious disease. A transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium enables the provision of the orally administrable vaccine against a coronavirus infectious disease. The transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium can induce humoral immunity and cellular immunity through oral administration to suppress an increase in severity of pneumonia or the like even after viral infection.

Abstract: A negative electrode includes a negative electrode protecting layer that is disposed so as to cover a negative electrode active material layer formed on at least one surface of a negative electrode core in a thickness direction and that has higher electrical resistance than the negative electrode active material layer. The negative electrode active material layer includes a first surface and a second surface. The first surface is formed in a region extending from an edge at one end to a boundary 300 ?m away from the edge in a width direction. The second surface is positioned closer than the first surface to the other end. Regarding the negative electrode protecting layer, the average value of the first thickness of a first portion covering the first surface is 1.7 or more times larger than the maximum value of the second thickness of a second portion covering the second surface.

Abstract: A pulse duration measuring apparatus includes a polarizing beam splitter for splitting a pulsed laser beam into a first laser beam and a second laser beam, a first mirror for reflecting the first laser beam traveling toward the polarizing beam splitter, a second mirror for reflecting the second laser beam traveling toward the polarizing beam splitter, a first quarter wavelength plate disposed between the polarizing beam splitter and the first mirror, a second quarter wavelength plate disposed between the polarizing beam splitter and the second mirror, an optical path length changing unit for moving the first mirror or the second mirror to change the length of the respective optical paths, a nonlinear crystal body for allowing a combined laser beam to pass therethrough, and a photodetector for measuring an optical intensity of the combined laser beam that has passed through the nonlinear crystal body.

Abstract: A negative electrode active material slurry is applied to one surface of a strip-shaped negative electrode core so as to form multiple lines of the negative electrode active material slurry, the lines extending in an X direction and being spaced from each other in a Y direction. Subsequently, while keeping the negative electrode core aloft, first hot air is blown toward the negative electrode core from at least a lower side in a vertical direction, and then, while keeping the negative electrode core aloft, first cooling air having a lower temperature than the first hot air is blown toward the negative electrode core from at least the lower side in the vertical direction so as to decrease the temperature of the negative electrode core to 40° C. or lower.

Abstract: A pneumatic tire comprises a sidewall portion which is provided in its radially outer part with first protrusions and circumferential ribs. The first protrusions are arranged in the tire circumferential direction at intervals. The circumferential ribs are disposed between and connect between the first protrusions. The first protrusions and the circumferential ribs protrude from the outer surface of the radially outer part, and the protruding amount of the circumferential ribs is less than the protruding amount of the first protrusions. The first protrusions each have side walls protruding from the outer surface and extending in the tire radial direction.

Abstract: A negative electrode includes a negative electrode protecting layer that is disposed so as to cover a negative electrode active material layer formed on at least one surface of a negative electrode core in a thickness direction and that has higher electrical resistance than the negative electrode active material layer. The negative electrode active material layer includes a first surface and a second surface. The first surface is formed in a region extending from an edge at one end to a boundary 300 ?m away from the edge in a width direction. The second surface is positioned closer than the first surface to the other end. Regarding the negative electrode protecting layer, the average value of the first thickness of a first portion covering the first surface is 1.7 or more times larger than the maximum value of the second thickness of a second portion covering the second surface.

Abstract: A negative electrode active material slurry is applied to one surface of a strip-shaped negative electrode core so as to form multiple lines of the negative electrode active material slurry, the lines extending in an X direction and being spaced from each other in a Y direction. Subsequently, while keeping the negative electrode core aloft, first hot air is blown toward the negative electrode core from at least a lower side in a vertical direction, and then, while keeping the negative electrode core aloft, first cooling air having a lower temperature than the first hot air is blown toward the negative electrode core from at least the lower side in the vertical direction so as to decrease the temperature of the negative electrode core to 40° C. or lower.

Abstract: A laser processing method for performing groove processing by applying to a workpiece a laser beam of such a wavelength as to be absorbed in the workpiece includes: a protective member disposing step of disposing a protective member on an upper surface of the workpiece; a liquid layer forming step of forming a liquid layer on the upper surface of the workpiece; a laser beam applying step of applying the laser beam through the liquid layer to subject the upper surface of the workpiece to groove processing and to produce minute bubbles; and a debris removing step of removing debris from inside of grooves by rupture of the bubbles.

Abstract: A pneumatic tire comprises a sidewall portion which is provided in its radially outer part with first protrusions and circumferential ribs. The first protrusions are arranged in the tire circumferential direction at intervals. The circumferential ribs are disposed between and connect between the first protrusions. The first protrusions and the circumferential ribs protrude from the outer surface of the radially outer part, and the protruding amount of the circumferential ribs is less than the protruding amount of the first protrusions. The first protrusions each have side walls protruding from the outer surface and extending in the tire radial direction.

Abstract: A laser machining apparatus has a laser beam irradiation unit that includes: a pulsed laser oscillator that oscillates a pulsed laser beam at a given repetition frequency; first and second condensers that collect the pulsed laser beam oscillated by the pulsed laser oscillator; and a beam splitting unit arranged between the pulsed laser oscillator and the first and second condensers to split the pulsed laser beam oscillated by the pulsed laser oscillator and direct the resultant beams alternately toward the first and second condensers. The beam splitting unit includes a photoelastic modulator that has a piezo element and a synthetic quartz formed in one piece and modulates the laser beam so that a polarization plane of the laser beam is alternately at 0 and 90 degrees by applying, to the piezo element, a high frequency voltage at a frequency that matches the natural frequency of the synthetic quartz.

Abstract: A laser machining apparatus has a laser beam irradiation unit that includes: a pulsed laser oscillator that oscillates a pulsed laser beam at a given repetition frequency; first and second condensers that collect the pulsed laser beam oscillated by the pulsed laser oscillator; and a beam splitting unit arranged between the pulsed laser oscillator and the first and second condensers to split the pulsed laser beam oscillated by the pulsed laser oscillator and direct the resultant beams alternately toward the first and second condensers. The beam splitting unit includes a photoelastic modulator that has a piezo element and a synthetic quartz formed in one piece and modulates the laser beam so that a polarization plane of the laser beam is alternately at 0 and 90 degrees by applying, to the piezo element, a high frequency voltage at a frequency that matches the natural frequency of the synthetic quartz.

Abstract: A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.

Abstract: A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) 1

Abstract: A films composite useful for various printing methods, and particularly UV ray flexographic printing, includes a top layer formed on a substrate film made from a synthetic polymer, particularly polypropylene, containing a binder resin and having an arithmetical mean roughness Ra of 0.2 to 3.5 determined in accordance with JIS B 0601 and, optionally, an anchor layer formed between the substrate film and the top layer and containing an adhesive resin and an adhesive undercoat layer formed between the substrate film and the anchor layer and containing an adhesive resin.

Abstract: A film laminate for printing comprises a polyolefin film in which at least one side is surface-modified and an anchor layer formed on the surface-modified side of the polyolefin film and containing an oxazoline group-modified resin. The film laminate is prepared by subjecting at least one side of a longitudinally oriented polyolefin film to a corona discharge treatment, forming an ethylene-acrylic acid type copolymer layer on the corona discharge-treated side of the film, laterally orienting the film, and then forming an anchor layer comprising a binder resin, and an oxazoline group-modified resin, on the modified surface of the surface-modified polyolefin film subjected to the corona discharge treatment. The film laminate for printing is excellent in its transparency and it is also excellent in the adhesion to a coated layer.

Abstract: A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.

Abstract: A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) 1

Abstract: A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.

Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.

Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.