Abstract: A bonded substrate includes a substrate, a metal plate forming a stacked state with the substrate, and bonding member. The metal plate has a first surface on the substrate side and a second surface opposite; wherein an edge of the first surface is located outside an edge of the second. The bonding member is disposed between the substrate and plate to bond the plate and substrate, and protrudes from the edge over an entire periphery of the plate. In cut surfaces obtained by cutting the bonded substrate, a peripheral surface length (A) from a portion corresponding to a peripheral edge of the first surface to a corresponding portion of the second, protrusion length of the bonding member, and thickness (C) of the metal plate satisfy first and second expressions. 0.032?B/(A+B)?0.400??(First Expression) 0.5 (mm)?C?2.

Abstract: A ceramic-copper composite having a flat plate shape, including: a ceramic layer; a copper layer; and a brazing material layer present between the ceramic layer and the copper layer. When a region having a length of 1,700 ?m in a long-side direction is a region P on a cut surface of the ceramic-copper composite obtained when the ceramic-copper composite is cut with a plane perpendicular to a main surface of the ceramic-copper composite, an average crystal grain size D1 of copper crystals at least partially present in a region P1 within 50 ?m on a side of the copper layer from an interface between the ceramic layer and the brazing material layer in the region P is 30 ?m or more and 100 ?m or less.

Abstract: An object of the present invention is to provide a pulverized coal drying system for a pulverizer, a pulverized coal drying method therefor, a pulverized coal drying program, a pulverizer, and an integrated gasification combined cycle capable of stably drying a carbonaceous feedstock irrespective of the type of the carbonaceous feedstock to be used. There is provided a controller (50) of a pulverizer (10) that dries a supplied carbonaceous feedstock by using a drying fluid and includes a flow rate controller that controls the flow rate of the drying fluid within upper and lower limits of the flow rate of the drying fluid that are set to dry a plurality of types or the carbonaceous feedstock having different moisture contents in such a way that the temperature of the drying fluid discharged from the pulverizer (10) approaches a target temperature.

Abstract: The object is to provide a powder fuel feed apparatus, a gasifier unit, and an integrated gasification combined cycle and a control method of a powder fuel feed apparatus that can suppress deformation of a sintered metal filter with simple and inexpensive configuration. An embodiment includes: a distributor pipe (89) in which a mixed gas containing moisture and a gas in which pulverized coal and nitrogen transported with the pulverized coal are mixed is transported; and a diluting nitrogen system (90) that, when a flow velocity of the mixed gas is less than a predetermined threshold, additionally supplies a diluting nitrogen to a mixing chamber (97) connected to the distributor pipe (89) and forming a part of the distributor pipe (89), and the diluting nitrogen system (90) continuously supplies a predetermined flow rate of the diluting nitrogen to the mixing chamber (97).

Abstract: A pressurizing nozzle includes a nozzle body; a filter that is provided to be perpendicular to the central axis direction of the nozzle body so as to cover the internal cross section of the nozzle body at the leading end portion on one end of the nozzle body and that is made of sintered metal having a prescribed thickness in the central axis direction; a retainer having an annular shape that is mounted to the leading end portion of the nozzle body so as to be disassemble and that fixes the outer circumferential portion of the filter via a pair of sealing parts; and a sealing portion that is disposed along the outer circumferential end face of the filter and that seals a fluid from flowing from the outer circumferential face toward the outside in the radial direction through the filter.

Abstract: A char discharge unit is for discharging char discharged from a filtration unit into a char storage unit in which a pressure is at least temporarily higher pressure than that in the filtration unit. The char discharge unit includes a char discharge line connected to a lower side of the filtration unit in a vertical direction and connected to the char storage unit; a lock hopper installed at an intermediary point of the char discharge line to temporarily store the char; an admission valve installed in the char discharge line between the lock hopper and the filtration unit; a control valve installed in the char discharge line between the lock hopper and the char storage unit; and a control device configured to close the control valve when the admission valve is open, and to close the admission valve when the control valve is open.

Abstract: Provided is a powder fuel supply apparatus comprising a distributor (84) that branches supplied powder fuel to a plurality of branch tubes (82), a plurality of burners (126a) connected to downstream ends (82a) of the plurality of branch tubes (82), respectively, to supply char into a gasification furnace that gasifies the powder fuel, a flow nozzle (85) provided in each of the plurality of branch tubes (82), to apply pressure loss to char flow in the branch tube (82), a differential pressure gauge (86) that measures a differential pressure generated by the flow nozzle (85), and a control unit that determines decrease in flow velocity of the char flow based on the differential pressure obtained by the differential pressure gauge (86).

Abstract: A powder supply hopper pressurizing apparatus including a first buffer tank in which pressurizing gas to be supplied to a powder supply hopper is accumulated at a predetermined pressure, a second buffer tank, a lower part pressure adjustment nitrogen system connected to the powder supply hopper, to supply the gas toward powder fuel stored in the powder supply hopper when supplying the powder fuel to a burner, and a control unit that controls the first buffer tank to pressurize the powder supply hopper to a first pressure and then controls the second buffer tank to pressurize the powder supply hopper to a second pressure, and where the control unit determines that one of the first buffer tank or the second buffer tank is non-usable, the control unit pressurizes the powder supply hopper by use of the first or second buffer tank that is operable, and the gas supply system.

Abstract: A pulverized-fuel supply unit includes a hopper, first nozzles, second nozzles, a pressurizing-gas supply device, a fluidization-gas supply device, and a pulverized-fuel supply line. The hopper has a hollow to store therein pulverized fuel. The first nozzles are provided to the hopper. The second nozzles are provided to a vertically lower part of the hopper below the plurality of first nozzles. The pressurizing-gas supply device is configured to supply pressurizing gas to increase internal pressure of the hopper. The fluidization-gas supply device is configured to supply fluidization gas to fluidize the pulverized fuel in the hopper. The pulverized-fuel supply line is provided to a vertically lower part of the hopper. The pressurizing-gas supply device supplies pressurizing gas to the first nozzles and the second nozzles. The fluidization-gas supply device supplies fluidization gas to the second nozzles.

Abstract: A char discharge unit is for discharging char discharged from a filtration unit into a char storage unit in which a pressure is at least temporarily higher pressure than that in the filtration unit. The char discharge unit includes a char discharge line connected to a lower side of the filtration unit in a vertical direction and connected to the char storage unit; a lock hopper installed at an intermediary point of the char discharge line to temporarily store the char; an admission valve installed in the char discharge line between the lock hopper and the filtration unit; a control valve installed in the char discharge line between the lock hopper and the char storage unit; and a control device configured to close the control valve when the admission valve is open, and to close the admission valve when the control valve is open.

Abstract: Provided is a pressurizing system which includes: a pressurizing nozzle configured to supply a pressurizing gas into a hopper (3) where pulverized coal is accumulated; a filter configured to face a space in the hopper (3) where the pulverized coal is accumulated, and to allow the pressurizing gas to pass through the filter, the filter being provided at an end of the pressurizing nozzle; buffer tanks (5a), (5b) in which a pressurizing gas to be supplied to the hopper (3) is collected at a first predetermined pressure; and a pressure control means configured to start, at a time of starting pressurization of the hopper (3), supply of a pressurizing gas at a second predetermined pressure which is lower than the first predetermined pressure of the pressurizing gas collected in the buffer tanks (5a), (5b).

Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.

Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.

Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.

Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.

Abstract: Provided are a char feeding hopper that makes it possible to accurately measure char, a char recovery system, and a coal gasification combined power generation system. The char feeding hopper comprises: a char feeding hopper body that feeds separated char to a coal gasifier side; at least two casing tubes (121, 122) that are inserted from a side wall of the char feeding hopper body and that are provided so as to be aligned with one another in the vertical axis direction; a radiation source section (101) that is provided within the casing tube (121) and that emits ?-rays within the char feeding hopper body; and a ?-ray detector that is provided within the casing tube (122) and that detects emitted ?-rays. The cross-section of each casing tube (121, 122) has a shape that is provided with a tapered section (200) having an apex angle on the upper edge thereof.

Abstract: A pulverized-fuel supply unit includes a hopper, first nozzles, second nozzles, a pressurizing-gas supply device, a fluidization-gas supply device, and a pulverized-fuel supply line. The hopper has a hollow to store therein pulverized fuel. The first nozzles are provided to the hopper. The second nozzles are provided to a vertically lower part of the hopper below the plurality of first nozzles. The pressurizing-gas supply device is configured to supply pressurizing gas to increase internal pressure of the hopper. The fluidization-gas supply device is configured to supply fluidization gas to fluidize the pulverized fuel in the hopper. The pulverized-fuel supply line is provided to a vertically lower part of the hopper. The pressurizing-gas supply device supplies pressurizing gas to the first nozzles and the second nozzles. The fluidization-gas supply device supplies fluidization gas to the second nozzles.

Abstract: Provided is a pressurizing system which includes: a pressurizing nozzle configured to supply a pressurizing gas into a hopper (3) where pulverized coal is accumulated; a filter configured to face a space in the hopper (3) where the pulverized coal is accumulated, and to allow the pressurizing gas to pass through the filter, the filter being provided at an end of the pressurizing nozzle; buffer tanks (5a), (5b) in which a pressurizing gas to be supplied to the hopper (3) is collected at a first predetermined pressure; and a pressure control means configured to start, at a time of starting pressurization of the hopper (3), supply of a pressurizing gas at a second predetermined pressure which is lower than the first predetermined pressure of the pressurizing gas collected in the buffer tanks (5a), (5b).

Abstract: A semiconductor module includes a wiring substrate and two semiconductor devices mounted on the wiring substrate. The semiconductor module includes a housing having a rectangular frame body including four side walls. The housing includes a beam that bridges first side walls. A bus bar includes two end portions, upright portions each extending from one of the end portions in the thickness direction of an insulating substrate, bent portions each extending continuously with one of the upright portions, and an extension extending continuously with the bent portions. A section of the extension is embedded in the housing.

Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.