Patents by Inventor Konstantinos Gavardinas
Konstantinos Gavardinas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8658638Abstract: The present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering Compound (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 4, 2010Date of Patent: February 25, 2014Assignee: Eli Lilly and CompanyInventors: David Andrew Coates, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 8227468Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.Type: GrantFiled: October 14, 2011Date of Patent: July 24, 2012Assignee: Eli Lilly and CompanyInventors: Gary G. Deng, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Euibong Jemes Kim, Matthew Allen Schiffler
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Publication number: 20120095020Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.Type: ApplicationFiled: October 14, 2011Publication date: April 19, 2012Applicant: Eli Lilly and CompanyInventors: Gary G. DENG, Konstantinos GAVARDINAS, Prabhakar Kondaji JADHAV, Euibong Jemes KIM, Matthew Allen SCHIFFLER
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Publication number: 20110312954Abstract: The present invention provides a compound of the formula: Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering Compound (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 4, 2010Publication date: December 22, 2011Applicant: ELI LILLY AND COMPANYInventors: David Andrew Coates, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 7994164Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 9, 2008Date of Patent: August 9, 2011Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav
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Patent number: 7968587Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.Type: GrantFiled: November 6, 2007Date of Patent: June 28, 2011Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Patent number: 7807691Abstract: The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).Type: GrantFiled: May 10, 2006Date of Patent: October 5, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Douglas Richard Stack
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Patent number: 7803814Abstract: The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).Type: GrantFiled: December 8, 2004Date of Patent: September 28, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Patent number: 7728150Abstract: The present invention provides a compound of the formula: Formula (I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, hypertension, and atherosclerosis, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: GrantFiled: February 18, 2005Date of Patent: June 1, 2010Assignee: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Minmin Wang
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Publication number: 20100069404Abstract: The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.Type: ApplicationFiled: November 6, 2007Publication date: March 18, 2010Inventors: Konstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Publication number: 20090163472Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 9, 2008Publication date: June 25, 2009Inventors: Konstantinos GAVARDINAS, Prabhakar Kondaji Jadhav
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Publication number: 20080176864Abstract: The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).Type: ApplicationFiled: May 10, 2006Publication date: July 24, 2008Inventors: Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Douglas Richard Stack, Ian Roger Clemens
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Publication number: 20070185161Abstract: The present invention provides a compound of the formula: Formula (I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, hypertension, and atherosclerosis, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: ApplicationFiled: February 18, 2005Publication date: August 9, 2007Inventors: Konstantinos Gavardinas, Prabhakar Jadhav, Minmin Wang
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Publication number: 20070037788Abstract: The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).Type: ApplicationFiled: December 8, 2004Publication date: February 15, 2007Applicant: Eli Lilly and CompanyInventors: Konstantinos Gavardinas, Jonathan Green, Prabhakar Jadhav, Donald Matthews
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Publication number: 20060235222Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: ApplicationFiled: January 20, 2004Publication date: October 19, 2006Applicant: ELI LILLY AND COMPANYInventors: Michael Bell, Konstantinos Gavardinas, Douglas Gernert, Timothy Grese, Prabhakar Jadhav, Peter Lander, Mitchell Steinberg