Patents by Inventor Kotoe Ohta

Kotoe Ohta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210000817
    Abstract: A tableted pharmaceutical composition contains nalfurafine or a pharmaceutically acceptable acid addition salt thereof and is excellent in formability and quality control of related substances. The tableted pharmaceutical composition includes nalfurafine or a pharmaceutically acceptable acid addition salt thereof, a binder component, and a carrier, wherein the above mentioned nalfurafine or a pharmaceutically acceptable acid addition salt thereof is contained in an amount of 0.1 to 10 ?g, and the weight of the above mentioned binder component is 100,000 to 2,000,000 weight % based on the weight of the above mentioned nalfurafine or a pharmaceutically acceptable acid addition salt thereof and 5 to 20 weight % based on the total weight of the resulting pharmaceutical composition, or 20,000 to 500,000 weight % and 1 to 5 weight % based on the total weight of the resulting pharmaceutical composition.
    Type: Application
    Filed: March 30, 2018
    Publication date: January 7, 2021
    Inventors: Satoshi Minakami, Suguru Takaki, Kotoe Ohta, Yasuhide Horiuchi
  • Publication number: 20190262270
    Abstract: A solid preparation includes a 4,5-epoxymorphinan derivative or a pharmaceutically acceptable acid addition salt thereof, which is stable to light even without light shielding coating. The solid preparation includes an active ingredient composed of a 4,5-epoxymorphinan derivative or a pharmaceutically acceptable acid addition salt thereof, and one or more stabilizing agents selected from the group consisting of n-propyl gallate, sodium hydrogensulfite, dibutylhydroxytoluene, butylhydroxyanisole, tocopherol and D-isoascorbic acid, wherein the amount of the above active ingredient is 0.00001 to 0.01% by weight of the solid preparation, and the amount of the above stabilizing agent is 0.005 to 5% by weight of the solid preparation.
    Type: Application
    Filed: July 28, 2017
    Publication date: August 29, 2019
    Applicant: Toray Industries, Inc.
    Inventors: Suguru TAKAKI, Satoshi MINAKAMI, Kotoe OHTA
  • Publication number: 20180338927
    Abstract: In a system where phase separation into two phases occurs when an ether cellulose derivative (A), a polymer (B) different from the ether cellulose derivative (A), and an alcohol solvent (C) are mixed together, the two phases including a solution phase mainly containing the ether cellulose derivative (A) and a solution phase mainly containing the polymer (B), the two separated phases containing approximately the same solvent, an emulsion is formed and brought into contact with a poor solvent (D) to provide an ether cellulose derivative microparticle having an average particle diameter of 1 to 1,000 ?m, a linseed oil absorption of 50 to 1,000 mL/100 g, and an average surface pore size of 0.05 to 5 ?m.
    Type: Application
    Filed: October 26, 2016
    Publication date: November 29, 2018
    Inventors: Takahiko Otsubo, Kotoe Ohta, Yuji Echigo, Hiroshi Takezaki, Suguru Takaki, Satoshi Minakami, Akinori Ito, Hisashi Miyama
  • Patent number: 10022331
    Abstract: A coating agent imparts gas barrier properties to a solid preparation while keeping rapid disintegration properties of the solid preparation, and a coating formed therewith, and provides a coated solid preparation that maintains its rapid disintegration properties and gas barrier properties, and does not generate cracks in the coating under humidified conditions. The coating agent for a solid preparation contains lactose and a swelling clay, but does not contain a water-soluble polymer, wherein the weight of the swelling clay is 20 to 50% with respect to the weight of the solid content.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 17, 2018
    Assignee: Toray Industries, Inc.
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuchi
  • Publication number: 20170105940
    Abstract: A coating agent imparts gas barrier properties to a solid preparation while keeping rapid disintegration properties of the solid preparation, and a coating formed therewith, and provides a coated solid preparation that maintains its rapid disintegration properties and gas barrier properties, and does not generate cracks in the coating under humidified conditions. The coating agent for a solid preparation contains lactose and a swelling clay, but does not contain a water-soluble polymer, wherein the weight of the swelling clay is 20 to 50% with respect to the weight of the solid content.
    Type: Application
    Filed: March 31, 2015
    Publication date: April 20, 2017
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuchi
  • Patent number: 9084817
    Abstract: A chemically stable oral preparation with an excellent dissolution property comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof is disclosed. The oral preparation according to the present invention comprises a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof as an effective ingredient and an organic acid, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C. The method for improving dissolution property and chemical stability of an oral preparation according to the present invention comprises incorporating an organic acid in the oral preparation comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: July 21, 2015
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Kotoe Ohta, Satoshi Minakami, Hiroyuki Tokumitsu
  • Patent number: 8829019
    Abstract: The present invention relates to a stable tablet comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the tablet according to the present invention comprises: (1) as the effective ingredient, a specific 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt; (2) sodium thiosulfate; (3) at least one selected from the group consisting of saccharides and sugar alcohols; and (4) crospovidone, sodium carboxymethyl starch or a mixture thereof, in which tablet the content of the aforementioned (4) is 1 to 20% by weight per unit weight containing the aforementioned effective ingredient.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: September 9, 2014
    Assignee: Toray Industries, Inc.
    Inventors: Kotoe Ohta, Suguru Takaki, Yasuhide Horiuchi
  • Patent number: 8715730
    Abstract: The present invention relates to a stable orally disintegrating coated tablet containing a drug, wherein the tablet is coated with a coating layer containing a water-soluble substance and a polyvinyl alcohol resin of not less than 5% by weight based on the weight of the coating layer, the water-soluble substance dissolving in an amount of 1 g or more in less than 10 mL of water at 20° C., having a hydroxyl group(s) in its molecule, and having a molecular weight of not more than 200 per a unit hydroxyl group. There is provided a stable orally disintegrating coated tablet which does not cause a crack in the coating layer even when the orally disintegrating tablet has been swollen by moisture absorption under high humidity, while ensuring rapid disintegration properties in an oral cavity. In the case of an orally disintegrating tablet containing a light-unstable drug, degradation of the drug can be suppressed by blending a light shading agent in the coating layer.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: May 6, 2014
    Assignee: Toray Industries, Inc.
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuch
  • Patent number: 8420662
    Abstract: It is an object of the present invention to provide a stable solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the present invention provides the stable solid preparation comprising the 4,5-epoxymorphinan derivative or the pharmacologically acceptable acid addition salt thereof as the effective ingredient, and comprising sodium thiosulfate, a sugar or a sugar alcohol and hydroxypropylcellulose having a low degree of substitution in an amount of 1 to 30% by weight per weight of a unit containing the effective ingredient.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: April 16, 2013
    Assignee: Toray Industries, Inc.
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuchi, Masato Kobayashi, Junko Kawasaki, Eijiro Horisawa
  • Publication number: 20120114752
    Abstract: The present invention relates to a stable tablet comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the tablet according to the present invention comprises: (1) as the effective ingredient, a specific 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt; (2) sodium thiosulfate; (3) at least one selected from the group consisting of saccharides and sugar alcohols; and (4) crospovidone, sodium carboxymethyl starch or a mixture thereof, in which tablet the content of the aforementioned (4) is 1 to 20% by weight per unit weight containing the aforementioned effective ingredient.
    Type: Application
    Filed: October 23, 2009
    Publication date: May 10, 2012
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Kotoe Ohta, Suguru Takaki, Yasuhide Horiuchi
  • Publication number: 20120058186
    Abstract: The present invention relates to a stable orally disintegrating coated tablet containing a drug, wherein the tablet is coated with a coating layer containing a water-soluble substance and a polyvinyl alcohol resin of not less than 5% by weight based on the weight of the coating layer, the water-soluble substance dissolving in an amount of 1 g or more in less than 10 mL of water at 20° C., having a hydroxyl group(s) in its molecule, and having a molecular weight of not more than 200 per a unit hydroxyl group. There is provided a stable orally disintegrating coated tablet which does not cause a crack in the coating layer even when the orally disintegrating tablet has been swollen by moisture absorption under high humidity, while ensuring rapid disintegration properties in an oral cavity. In the case of an orally disintegrating tablet containing a light-unstable drug, degradation of the drug can be suppressed by blending a light shading agent in the coating layer.
    Type: Application
    Filed: March 29, 2010
    Publication date: March 8, 2012
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuch
  • Publication number: 20100215750
    Abstract: A chemically stable oral preparation with an excellent dissolution property comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof is disclosed. The oral preparation according to the present invention comprises a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof as an effective ingredient and an organic acid, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C. The method for improving dissolution property and chemical stability of an oral preparation according to the present invention comprises incorporating an organic acid in the oral preparation comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C.
    Type: Application
    Filed: May 20, 2008
    Publication date: August 26, 2010
    Applicant: Toray Industries, Inc.
    Inventors: Kotoe Ohta, Satoshi Minakami, Hiroyuki Tokumitsu
  • Publication number: 20100120815
    Abstract: It is an object of the present invention to provide a stable solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the present invention provides the stable solid preparation comprising the 4,5-epoxymorphinan derivative or the pharmacologically acceptable acid addition salt thereof as the effective ingredient, and comprising sodium thiosulfate, a sugar or a sugar alcohol and hydroxypropylcellulose having a low degree of substitution in an amount of 1 to 30% by weight per weight of a unit containing the effective ingredient.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 13, 2010
    Inventors: Suguru Takaki, Kotoe Ohta, Yasuhide Horiuchi, Masato Kobayashi, Junko Kawasaki, Eijiro Horisawa
  • Publication number: 20060073205
    Abstract: The present invention relates to controlled release granules for medical use comprising a drug loaded porous silica particle, and at least one layer of a controlled release coating material, characterized in that the drug loaded porous silica core is prepared by immersing dry porous silica particles with a solution, suspension or emulsion comprising at least one pharmacologically active drug and the resulting wet drug loaded porous silica core is subsequently dried again. Furthermore, the invention concerns a method for preparing the controlled release composition.
    Type: Application
    Filed: October 4, 2004
    Publication date: April 6, 2006
    Inventors: Kotoe Ohta, Masayoshi Fuji, Takashi Takei, Masatoshi Chikazawa, Kenzo Toyoshima
  • Publication number: 20050244491
    Abstract: The present invention relates to a fast disintegrating tablet comprising meloxicam or a pharmaceutically acceptable salt thereof, starch or various starches, glidant and at least one additional excipient.
    Type: Application
    Filed: April 6, 2005
    Publication date: November 3, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Toshimitsu Ohki, Wakuko Yamaguchi, Kotoe Ohta
  • Publication number: 20040234596
    Abstract: The present invention relates to a fast disintegrating tablet comprising meloxicam or a pharmaceutically acceptable salt thereof, starch or various starches, glidant and at least one additional excipient.
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Toshimitsu Ohki, Wakuko Yamaguchi, Kotoe Ohta
  • Publication number: 20020187187
    Abstract: The present invention relates to a fast disintegrating tablet comprising meloxicam or a pharmaceutically acceptable salt thereof, starch or various starches, glidant and at least one additional excipient.
    Type: Application
    Filed: April 17, 2002
    Publication date: December 12, 2002
    Inventors: Toshimitsu Ohki, Wakuko Yamaguchi, Kotoe Ohta