Patents by Inventor Kousaku OHINATA

Kousaku OHINATA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250059233
    Abstract: Peptides and pharmaceutically acceptable salts thereof and peptide conjugates and pharmaceutically acceptable salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID NO:1) for use in treating a subject suffering from or at risk of an inflammatory disease or disorder, schizophrenia or psychosis, a neurodegenerative disease such as Parkinson's disease. Alzheimer's disease, or ALS, a gastrointestinal disease or disorder such as irritable bowel syndrome, inflammatory bowel disease. Crohn's disease, or constipation, pain (e.g., visceral pain), rheumatoid arthritis, migraine, headache, substance abuse (e.g., substance use disorder such as drug use disorder, polysubstance use disorder, alcohol use disorder, or nicotine use disorder, tobacco use disorder), drug addiction, a seizure disorder, major depressive disorder, atypical depression, a major depressive episode (MDE) (e.g.
    Type: Application
    Filed: December 14, 2022
    Publication date: February 20, 2025
    Inventors: Igor Grachev, Sooin Hwang, Takahide Koda, Harald Murk, Takashi Nishida, Kousaku Ohinata
  • Publication number: 20250034207
    Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID) NO: 34).
    Type: Application
    Filed: February 22, 2024
    Publication date: January 30, 2025
    Applicants: Kyoto University, Kazusa DNA Research Institute
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20250026786
    Abstract: Provided is a cognitive function-improving composition. Specifically, provided is a cognitive function-improving composition comprising at least one selected from the group consisting of a thermolysin digest of ovalbumin, a peptide comprising amino acid sequence LP, and a peptide comprising amino acid sequence LE.
    Type: Application
    Filed: November 25, 2022
    Publication date: January 23, 2025
    Inventors: Kousaku OHINATA, Takanobu NAKAJIMA, Maiko SHOBAKO, Kentaro KANEKO, Masaru SATO, Atsushi KURABAYASHI
  • Publication number: 20240301001
    Abstract: Provided is a composition for improving leptin resistance, a composition for enhancing leptin sensitivity, a composition for suppressing food intake, or a composition for anti-obesity. Specifically, provided is a composition for improving leptin resistance or enhancing leptin sensitivity, comprising a peptide comprising the amino acid sequence YAB as an active ingredient, wherein A is an amino acid residue having a basic side chain, and B is an amino acid residue having a nonpolar side chain or an amino acid residue having an acidic side chain.
    Type: Application
    Filed: June 24, 2022
    Publication date: September 12, 2024
    Inventors: Kousaku OHINATA, Kentaro KANEKO, Yukihiro TAKEKUMA, Shimon ABE, Saya ARAKI
  • Publication number: 20240287132
    Abstract: The present invention addresses the problem of providing a novel peptide which can treat, prevent or ameliorate anorexia. The present invention provides a peptide described in any one of the following items (1) to (3). (1) A peptide consisting of 4 to 9 inclusive contiguous amino acid residues in the amino acid sequence represented by SEQ ID NO: 1; (2) a peptide consisting of 4 to 12 inclusive contiguous amino acid residues in the amino acid sequence represented by SEQ ID NO: 2; and (3) a peptide consisting of an amino acid sequence having 90% or higher identity to the amino acid sequence represented by SEQ ID NO: 2.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 29, 2024
    Inventors: Kousaku Ohinata, Yuki Tokuyama, Junya Nakato, Hiroshi Iwakura, Kentaro Kaneko, Sayano Odaka, Masaru Sato, Hideyuki Suzuki, Akira Ito, Yuki Higuchi, Ryoko Nakayama
  • Publication number: 20240166686
    Abstract: The present invention provides peptides, salts thereof, peptide conjugates, and salts thereof having an anxiolytic-like effect, for example a peptide comprising any amino acid sequence selected from (i) an amino acid sequence SYLPPLTT (SEQ ID NO: 1), (ii) an amino acid sequence YHIEPV (SEQ ID NO: 2), (iii) an amino acid sequence YLLVK (SEQ ID NO: 3), (iv) an amino acid sequence SYLPPLT (SEQ ID NO: 4), (v) an amino acid sequence FLLVK (SEQ ID) NO. 5), and (vi) an amino acid sequence WLLVK (SEQ ID NO: 6).
    Type: Application
    Filed: May 19, 2023
    Publication date: May 23, 2024
    Applicants: Kyoto University, Kazusa DNA Research Institute
    Inventors: Kousaku OHINATA, Saeko KIMURA, Hideyuki SUZUKI
  • Publication number: 20240158440
    Abstract: A peptide which can be easily taken on a daily basis and which has few side effects and has various actions and a composition containing the peptide as an active ingredient are provided. A peptide having the amino acid sequence of (a) or (b) below is provided. (a) The amino acid sequence of SEQ ID NO: 1 (Asn-Leu-Pro-Pro-Leu-Thr). (b) An amino acid sequence in which one or several amino acids are substituted, deleted or added in the amino acid sequence of SEQ ID NO: 1. Moreover, a composition containing the peptide as an active ingredient is also provided.
    Type: Application
    Filed: March 24, 2022
    Publication date: May 16, 2024
    Applicants: MORINAGA MILK INDUSTRY CO., LTD., KYOTO UNIVERSITY
    Inventors: Kousaku OHINATA, Hikaru FUJII, Hajime NAKADA, Masaki KURIMOTO, Hiroshi OCHI
  • Publication number: 20230011813
    Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).
    Type: Application
    Filed: April 12, 2022
    Publication date: January 12, 2023
    Applicants: Kyoto University, Kazusa DNA Research Institute
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20220370546
    Abstract: The present invention addresses the problem of providing a novel peptide that can be used to treat, prevent, or ameliorate mood disorders. The present invention provides a peptide that has an amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and is 3 to 5 (inclusive) amino acids long. The peptide may consist of an amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4.
    Type: Application
    Filed: November 5, 2020
    Publication date: November 24, 2022
    Inventors: Kousaku OHINATA, Shinto JO, Hideyuki SUZUKI, Masaru SATO, Akira ITO, Yuki HIGUCHI
  • Patent number: 11464824
    Abstract: An object of the present invention is to provide a peptide having an excellent effect in terms of preventing deterioration in cognitive function and improving cognitive function, and provide its usage. The present invention uses the tripeptide represented by Tyr-Leu-Gly as an active ingredient of a composition for improving cognitive function or a composition for promoting brain-derived neurotrophic factor expression in the hippocampus. These compositions include a food composition, a food additive composition, and a pharmaceutical composition.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: October 11, 2022
    Assignee: THE FOOD SCIENCE INSTITUTE FOUNDATION
    Inventors: Kousaku Ohinata, Akitoshi Nagai, Daisuke Kozutsumi
  • Publication number: 20220194982
    Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID NO:34).
    Type: Application
    Filed: March 4, 2022
    Publication date: June 23, 2022
    Applicants: Kyoto University, Kazusa DNA Research Institute
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20210130406
    Abstract: The present invention addresses the problem of providing a novel peptide capable of treating, preventing, or ameliorating a mood disorder. The present invention provides a peptide having an amino acid sequence represented by SEQ ID NO: 1 and having an amino acid length of 6 to 20.
    Type: Application
    Filed: May 7, 2019
    Publication date: May 6, 2021
    Inventors: Kousaku OHINATA, Saho ASAKURA, Hideyuki SUZUKI, Masaru SATO, Akira ITO, Yuki HIGUCHI
  • Publication number: 20200390846
    Abstract: An object of the present invention is to provide a peptide having an excellent effect in terms of preventing deterioration in cognitive function and improving cognitive function, and provide its usage. The present invention uses the tripeptide represented by Tyr-Leu-Gly as an active ingredient of a composition for improving cognitive function or a composition for promoting brain-derived neurotrophic factor expression in the hippocampus. These compositions include a food composition, a food additive composition, and a pharmaceutical composition.
    Type: Application
    Filed: March 1, 2019
    Publication date: December 17, 2020
    Applicant: THE FOOD SCIENCE INSTITUTE FOUNDATION
    Inventors: Kousaku OHINATA, Akitoshi NAGAI, Daisuke KOZUTSUMI
  • Patent number: 10676505
    Abstract: Provided is a novel peptide having ACE inhibitory activity. Specifically, provided is a tripeptide consisting of Leu-Arg-Ala.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: June 9, 2020
    Assignee: SUNSTAR INC.
    Inventors: Naohisa Shobako, Kousaku Ohinata, Yuutarou Ogawa, Etsuko Kobayashi, Atsushi Ishikado, Hirohisa Suidou, Takashi Kusakari
  • Publication number: 20200071355
    Abstract: The present invention provides peptides, salts thereof, peptide conjugates, and salts thereof having an anxiolytic-like effect, for example a peptide comprising any amino acid sequence selected from (i) an amino acid sequence SYLPPLTT (SEQ ID NO: 1), (ii) an amino acid sequence YHIEPV (SEQ ID NO: 2), (iii) an amino acid sequence YLLVK (SEQ ID NO: 3), (iv) an amino acid sequence SYLPPLT (SEQ ID NO: 4), (v) an amino acid sequence FLLVK (SEQ ID NO: 5), and (vi) an amino acid sequence WLLVK (SEQ ID NO: 6).
    Type: Application
    Filed: March 2, 2018
    Publication date: March 5, 2020
    Inventors: Kousaku OHINATA, Saeko KIMURA, Hideyuki SUZUKI
  • Publication number: 20190284232
    Abstract: Peptides, salts thereof, peptide conjugates, and salts thereof having 5 to 15 amino acids and having an amino acid sequence comprising at least 5 consecutive amino acids from the amino acid sequence LSSTQAQQSX1 (SEQ ID NO:34).
    Type: Application
    Filed: September 6, 2017
    Publication date: September 19, 2019
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20190233472
    Abstract: Provided is a novel peptide having ACE inhibitory activity. Specifically, provided is a tripeptide consisting of Leu-Arg-Ala.
    Type: Application
    Filed: June 16, 2017
    Publication date: August 1, 2019
    Applicant: SUNSTAR INC.
    Inventors: Naohisa SHOBAKO, Kousaku OHINATA, Yuutarou OGAWA, Etsuko KOBAYASHI, Atsushi ISHIKADO, Hirohisa SUIDOU, Takashi KUSAKARI
  • Patent number: 10280202
    Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: May 7, 2019
    Assignees: KYOTO UNIVERSITY, KAZUSA DNA RESEARCH INSTITUTE
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20180044386
    Abstract: This invention provides a peptide consisting of (i) the amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) the amino acid sequence LSSTQAQQSW (SEQ ID NO: 6), or (iii) the amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).
    Type: Application
    Filed: March 2, 2016
    Publication date: February 15, 2018
    Inventors: Kousaku Ohinata, Yukiha Mori, Hideyuki Suzuki
  • Publication number: 20170281582
    Abstract: An agent for secreting ghrelin, comprising ornithine or a salt thereof as an active ingredient, an agent for enhancing eating activity, comprising ornithine or a salt thereof as an active ingredient, and an agent for enhancing gastrointestinal activity, comprising ornithine or a salt thereof as an active ingredient.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kousaku OHINATA, Yee HO, Takafumi MIZUSHIGE, Kentaro KANEKO, Saori AKIZUKI, Koji MORISHITA