Patents by Inventor Kristin Hedgepath Gilchrist

Kristin Hedgepath Gilchrist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210251558
    Abstract: A computer implemented method is disclosed for detecting a mild traumatic brain injury (mTBI) on a subject having recently suffered a head injury. The method includes (1) receiving first electrocardiogram (ECG) data from the subject during a first transition from a first position to a second position; and (2) determining a probability value of mTBI within the subject based at least partially on the first ECG data during the first transition. The first position may be a prone position or a supine position and the second position may be a standing position.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 19, 2021
    Inventors: Kristin Hedgepath Gilchrist, Sonia Grego, Gregory Frederick Lewis, Meghan Sarah Hegarty-Craver
  • Publication number: 20140335496
    Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.
    Type: Application
    Filed: December 4, 2012
    Publication date: November 13, 2014
    Applicants: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, Scott H. Randell
  • Patent number: 8866081
    Abstract: A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: October 21, 2014
    Assignee: Research Triangle Institute
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner
  • Patent number: 8866080
    Abstract: A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 21, 2014
    Assignee: Research Triangle Institute
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner, Dorota Temple
  • Publication number: 20140308688
    Abstract: A multiple flow-based microfluidic cell culture system that emulates mammalian physiology is provided. Tissue-mimicking cell cultures are connected by flow within a physiologically meaningful arrangement so that the pharmacokinetics of various agents to be tested in the system emulate in vivo conditions. The system includes at least two organ tissue modules, each organ tissue module including a first chamber containing an organ tissue cell, the first chamber including an inlet and an outlet for flow of an organ tissue cell-specific culture medium; a second chamber including an inlet and an outlet for flow of a blood material; and a semi-permeable membrane separating the first and second chambers. The flow of blood material through each organ tissue module is interconnected and the flow of tissue-cell specific culture medium is directed to a single organ tissue module.
    Type: Application
    Filed: December 7, 2012
    Publication date: October 16, 2014
    Inventors: Sonia Grego, Brian Rhys Stoner, Kristin Hedgepath Gilchrist, Timothy Raymond Fennell, Ann Pitruzzello
  • Patent number: 8700134
    Abstract: The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: April 15, 2014
    Assignee: Research Triangle Institute
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, David Edward Dausch, Michael Kasper Lamvik
  • Publication number: 20140080729
    Abstract: An optical sensing device and associated apparatus are configured for multiplexed detection of specific analytes in fluid samples. The device has a wavelength-tunable grating-coupler configuration in which a grating is disposed on a surface of a waveguide. Different regions of the grating may be functionalized with different receptors, and may form binding-specific sensors and reference sensors. The receptors are exposed to a fluid sample utilizing a fluidic structure mounted to the device. The device utilizes evanescent waves to sense analytes bound to the waveguide surface. The evanescent wave is sensitive to changes in refractive index at (or near) the waveguide surface. Changes in refractive index occur proportionally to the mass of the bound analyte. The apparatus utilizes a tunable light source to implement swept wavelength interrogation while the input beam is held at a fixed coupling angle relative to the waveguide and grating.
    Type: Application
    Filed: March 16, 2012
    Publication date: March 20, 2014
    Applicant: Research Triangle Institute, International
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist
  • Publication number: 20130267853
    Abstract: An ultrasound device including an ultrasonic transducer device having a plurality of transducer elements forming a transducer array is provided. Each transducer element includes a piezoelectric material disposed between a first electrode and a second electrode. One of the first and second electrodes is a ground electrode and the other of the first and second electrodes is a signal electrode. The ultrasound device further includes a cable assembly having a plurality of connective signal elements and a plurality of connective ground elements extending in substantially parallel relation therealong. Each connective element is configured to form an electrically-conductive engagement with respective ones of the signal electrodes and the ground electrodes of the transducer elements in the transducer array. The connective ground elements are alternatingly disposed with the connective signal elements across the cable assembly, to provide shielding between the connective signal elements.
    Type: Application
    Filed: May 31, 2013
    Publication date: October 10, 2013
    Inventors: David Dausch, James Carlson, Kristin Hedgepath Gilchrist, Stephen Hall
  • Publication number: 20130261467
    Abstract: A method and apparatus directed to formation of a connection with an ultrasonic transducer apparatus (UTA) comprising a transducer device having first and second electrodes is provided. The UTA is engaged with an interposer device surface. The interposer device is greater in at least one lateral dimension than and extends laterally outward of the UTA, and comprises at least two laterally-extending conductors. A conductive engagement is formed between the first and second electrodes and respective first ends of the conductors. A connection support substrate is engaged with the interposer device about second ends of the conductors, and includes at least two connective elements for forming a conductive engagement with the respective second ends of the conductors. The UTA is then inserted into a catheter member lumen such that the device plane of the UTA and the at least two connective elements extend axially along the lumen.
    Type: Application
    Filed: May 31, 2013
    Publication date: October 3, 2013
    Inventors: David Dausch, James Carlson, Kristin Hedgepath Gilchrist
  • Publication number: 20120080612
    Abstract: The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other
    Type: Application
    Filed: February 26, 2010
    Publication date: April 5, 2012
    Applicant: Research Triangle Institute
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, David Edward Dausch, Michael Kasper Lamvik
  • Publication number: 20110031388
    Abstract: A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.
    Type: Application
    Filed: February 27, 2009
    Publication date: February 10, 2011
    Applicant: Research Triangle Institute
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner, Dorota Temple
  • Publication number: 20110006204
    Abstract: A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.
    Type: Application
    Filed: February 24, 2009
    Publication date: January 13, 2011
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Christopher A. Bower, Kristin Hedgepath Gilchrist, Brian R. Stoner