Patents by Inventor Kristin V. TARBELL

Kristin V. TARBELL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DCAF4L2-SPECIFIC T-CELL RECEPTORS
    Publication number: 20250009799
    Abstract: Provided herein are T-cell receptors (TCRs) that when expressed recombinantly on the surface of a T cell are able to recognize the DCAF4L2-derived peptide ILQDGQFLV (SEQ ID NO:1) when presented by HLA-A*02:01 sufficiently to activate the recombinant T cell. Importantly, exemplary TCRs provided herein were thoroughly screened for lack of cross-reactivity with similar peptides that may be presented by normal cells or tissue and for alloreactivity.
    Type: Application
    Filed: December 15, 2022
    Publication date: January 9, 2025
    Applicant: AMGEN INC.
    Inventors: Sungeun KIM, Yan ZHENG, Kristin V. TARBELL, Dhanashi S. BAGAL, Sheree JOHNSTONE