Patents by Inventor Krisztina Pongracz

Krisztina Pongracz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of protected 3?-amino nucleoside monomers
    Patent number: 8748593
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: June 10, 2014
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Oligonucleotide Conjugates
    Publication number: 20130253042
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Application
    Filed: May 10, 2013
    Publication date: September 26, 2013
    Applicant: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • Oligonucleotide conjugates
    Patent number: 8440635
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: May 14, 2013
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
    Publication number: 20130065950
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 14, 2013
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
    Publication number: 20120329858
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: August 21, 2012
    Publication date: December 27, 2012
    Inventors: Sergei GRYAZNOV, Krisztina Pongracz
  • MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
    Publication number: 20120129918
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: September 20, 2010
    Publication date: May 24, 2012
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Oligonucleotide Conjugates
    Publication number: 20100016416
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Application
    Filed: July 17, 2009
    Publication date: January 21, 2010
    Applicant: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
    Publication number: 20090286853
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: November 21, 2008
    Publication date: November 19, 2009
    Inventors: SERGEI GRYAZNOV, KRISZTINA PONGRACZ
  • Oligonucleotide conjugates
    Patent number: 7563618
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: July 21, 2009
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • Synthesis of Protected 3'-Amino Nucleoside Monomers
    Publication number: 20090105468
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Application
    Filed: December 22, 2008
    Publication date: April 23, 2009
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Modified oligonucleotides for telomerase inhibition
    Patent number: 7494982
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: February 24, 2009
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Synthesis of protected 3?-amino nucleoside monomers
    Patent number: 7485717
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: February 3, 2009
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Rna Amidates and Thioamidates for Rnai
    Publication number: 20070275919
    Abstract: The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3??P5? phosphoramidate (NP) and ribo-N3??P5? thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.
    Type: Application
    Filed: November 3, 2004
    Publication date: November 29, 2007
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
    Publication number: 20070037770
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3?-NHP(O)(S?)O-5? linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3??P5? phosphoramidates and to exhibit a much higher acid stability.
    Type: Application
    Filed: October 25, 2006
    Publication date: February 15, 2007
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray
  • Treating cancer using an oligonucleotide N3?->N5? thiophosphoramidate
    Patent number: 7138383
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3?-NHP(O)(S?)O-5? linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3??P5? phosphoramidates and to exhibit a much higher acid stability.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: November 21, 2006
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray
  • Synthesis of protected 3'-amino nucleoside monomers
    Publication number: 20060009636
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 12, 2006
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Modified oligonucleotides for telomerase inhibition
    Publication number: 20050113325
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: September 9, 2004
    Publication date: May 26, 2005
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Oligonucleotide N3'->P5' thiophosphoramidates: their synthesis and use
    Publication number: 20050049408
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3?-NHP(O)(S?)O-5? linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3??P5? phosphoramidates and to exhibit a much higher acid stability.
    Type: Application
    Filed: October 18, 2004
    Publication date: March 3, 2005
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray
  • Oligonucleotide N3??P5? Thiophosphoramidates: their synthesis and use
    Patent number: 6835826
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: December 28, 2004
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray
  • Oligonucleotide N3'P5' thiophosphoramidates: their synthesis and use
    Publication number: 20030212032
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.
    Type: Application
    Filed: June 17, 2003
    Publication date: November 13, 2003
    Applicant: GERON CORPORATION
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray