Patents by Inventor Kumiko Saeki

Kumiko Saeki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220390159
    Abstract: An air-conditioning management system includes: an air conditioning apparatus configured to carry out a refrigerant recovery operation of recovering a refrigerant from a refrigerant circuit that connects an outdoor unit and an indoor unit and sending the recovered refrigerant to each recovery unit of the outdoor unit; and a control unit configured to make a determination whether all the recovered refrigerant is sendable to each recovery unit before a start of the refrigerant recovery operation by the air conditioning apparatus, and to output, when determining that all the recovered refrigerant is not sendable to each recovery unit, a command for notifying the determination.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 8, 2022
    Applicant: DAIKIN INDUSTRIES, LTD.
    Inventors: Yuuta IYOSHI, Yoshiki YAMANOI, Kumiko SAEKI
  • Publication number: 20210177909
    Abstract: The present invention provides a composition having a metabolism-improving action, which comprises a supernatant of brown adipocytes or a purified product thereof. The present invention also provides a method of preparing the supernatant without using a culture solution comprising a high concentration of glucose. The present invention also provides a method of producing brown adipocytes using pluripotent stem cells, which are useful for preparing the supernatant of brown adipocytes. The present invention has succeeded in obtaining a supernatant having a metabolism-improving action from brown adipocytes. It was also possible to obtain the supernatant without using a culture solution comprising a high concentration of glucose. The present invention has also succeeded in producing brown adipocytes from pluripotent stem cells using a feeder-free culture system without adding a cytokine cocktail or the like.
    Type: Application
    Filed: August 14, 2019
    Publication date: June 17, 2021
    Inventors: Kumiko SAEKI, Norihiko KOBAYASHI, Masako OKA, Kazunori MATSUMURA, Miwako NISHIO, Tsugumine SHU, Toyotaka MORI
  • Publication number: 20190194607
    Abstract: The problem is to produce functional liver cells usable in testing the metabolism and toxicity of a drug, from pluripotent stem cells. The solution includes a method for producing highly functional liver cells using pluripotent stem cells, comprising, from pluripotent stem cells, acquiring primitive endoderm derived from the pluripotent stem cells by a process involving steps (A) and (B), from the primitive endoderm, acquiring liver precursor cells by a process involving step (C), and, from the liver precursor cells, acquiring the highly functional liver cells by a process involving step (D): (A) culturing under serum-free and feeder-free conditions; (B) culturing in the presence of albumin and at least one kind of cytokine; (C) culturing in the presence of SHH or an SHH agonist and at least one kind of cytokine; and (D) culturing and maturing in the presence of at least one kind of cytokine.
    Type: Application
    Filed: January 30, 2012
    Publication date: June 27, 2019
    Applicants: DNAVEC CORPORATION, NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE
    Inventors: Akira Yuo, Kumiko Saeki, Naoko Nakamura, Satoko Matsuyama, Miwako Nishio, Koichi Saeki, Mamoru Hasegawa
  • Patent number: 9492485
    Abstract: Provided are a method of producing brown adipocytes from pluripotent stem cells, a method of producing cell aggregates as an intermediate product thereof, pluripotent stem cell-derived cell aggregates and pluripotent stem cell-derived brown adipocytes produced by these methods, and cell therapy using the pluripotent stem cell-derived brown adipocytes. In the method of producing brown adipocytes from pluripotent stem cells, cell aggregates are produced from pluripotent stem cells by a method including the step (A), and brown adipocytes are prepared from the cell aggregates by a method including the step (B). The step (A) is a step of producing cell aggregates by non-adhesive culture of pluripotent stem cells in serum-free environment in the presence of a hematopoietic cytokine, and the step (B) is a step of producing brown adipocytes by adhesion culture of the cell aggregates in the presence of a hematopoietic cytokine.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: November 15, 2016
    Assignees: ID Pharma Co., Ltd., National Center for Global Health and Medicine
    Inventors: Kumiko Saeki, Akira Yuo, Miwako Nishio, Masako Kawasaki, Koichi Saeki, Mamoru Hasegawa
  • Publication number: 20140140967
    Abstract: Provided are a method of producing brown adipocytes from pluripotent stem cells, a method of producing cell aggregates as an intermediate product thereof, pluripotent stem cell-derived cell aggregates and pluripotent stem cell-derived brown adipocytes produced by these methods, and cell therapy using the pluripotent stem cell-derived brown adipocytes. In the method of producing brown adipocytes from pluripotent stem cells, cell aggregates are produced from pluripotent stem cells by a method including the step (A), and brown adipocytes are prepared from the cell aggregates by a method including the step (B). The step (A) is a step of producing cell aggregates by non-adhesive culture of pluripotent stem cells in serum-free environment in the presence of a hematopoietic cytokine, and the step (B) is a step of producing brown adipocytes by adhesion culture of the cell aggregates in the presence of a hematopoietic cytokine.
    Type: Application
    Filed: April 26, 2012
    Publication date: May 22, 2014
    Applicant: National Center for Global Health and Medicine
    Inventors: Kumiko Saeki, Akira Yuo, Miwako Nishio, Masako Kawasaki, Koichi Saeki, Mamoru Hasegawa