Patents by Inventor Kun-Liang Guan

Kun-Liang Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ISOLATING, EXPANDING AND ADMINISTERING CANCER SPECIFIC CD8+ T CELLS
    Publication number: 20200087625
    Abstract: Methods to isolate and expand tumor specific CD8+ T cells, and the use thereof, are provided. Also provided are method of using TLR7 agonists.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 19, 2020
    Inventors: Dennis A. Carson, Tomoko Hayashi, Kun-Liang Guan, Toshiro Moroishi
  • INHIBITORS OF HIPPO-YAP SIGNALING PATHWAY
    Publication number: 20150157584
    Abstract: This invention provides methods of preventing, reducing, delaying or inhibiting the proliferation, growth, migration and/or metastasis of cancer by administering an effective amount of an inhibitor of the Hippo-YAP signaling pathway.
    Type: Application
    Filed: May 31, 2013
    Publication date: June 11, 2015
    Applicants: The J. David Gladstone Institutes, The Regents of the University of California
    Inventors: Kun-Liang Guan, Faxing Yu, Sheng Ding
  • Diagnosis and Treatment of Diseases Arising from Defects in the Tuberous Sclerosis Pathway
    Publication number: 20080312267
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Application
    Filed: May 9, 2008
    Publication date: December 18, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Kun-Liang Guan
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Publication number: 20080207671
    Abstract: The present invention relates to compositions, methods for identifying, and methods for treating abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing, treating and preventing disorders caused by defects in the TSC signaling pathway (e.g., TSC-1, TSC-2, TSC-1/TSC-2, Rheb, mTOR, S6K, and 4EBP-1) such as tuberous sclerosis, diabetes, and complications related to diabetes (e.g., insulin resistance, obesity, nephropathy). The present invention further relates to compositions for treating and preventing disorders such as tuberous sclerosis, diabetes, and complications related to diabetes (e.g., insulin resistance, obesity, nephropathy).
    Type: Application
    Filed: July 31, 2007
    Publication date: August 28, 2008
    Applicant: The Regents of the University of Michigan
    Inventors: Kun-Liang Guan, Ken Inoki, Hiroyuki Mori
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Patent number: 7416724
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 26, 2008
    Assignee: The Regents of the University of Michigan
    Inventor: Kun-Liang Guan
  • Diagnosis and Treatment of Diseases Arising from Defects in the Tuberous Sclerosis Pathway
    Publication number: 20080199896
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Application
    Filed: October 29, 2007
    Publication date: August 21, 2008
    Applicant: The Regents of the University of Michigan
    Inventor: Kun-Liang Guan
  • Compositions and methods for detecting, preventing and treating seizures and seizure related disorders
    Publication number: 20080188461
    Abstract: The present invention relates to compositions and methods for the detecting, preventing, treating, and empirically investigating seizures and seizure related disorders (e.g., West syndrome, TSC, childhood absence epilepsy, benign focal epilepsies of childhood, juvenile myoclonic epilepsy (JME), temperol lobe epilepsy, frontal lobe epilepsy, Lennox-Gastaut syndrome, occipital lobe epilepsy). In particular, the present invention provides compositions and methods for detecting, treating, preventing and empirical investigating seizures and seizure related disorders through inhibition of mTOR function. In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents (e.g., rapamycin) in the detecting, preventing, treating, and empirical investigating of seizures and seizure related disorders.
    Type: Application
    Filed: June 29, 2007
    Publication date: August 7, 2008
    Applicant: Regents of the University of Michigan
    Inventors: Kun-Liang Guan, David Franz
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Publication number: 20070122860
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 31, 2007
    Inventor: Kun-Liang Guan
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Patent number: 7169594
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: January 30, 2007
    Inventor: Kun-Liang Guan
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Publication number: 20050070567
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Application
    Filed: November 24, 2003
    Publication date: March 31, 2005
    Applicant: The Regents of the University of Michigan
    Inventor: Kun-Liang Guan
  • Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
    Publication number: 20040106637
    Abstract: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
    Type: Application
    Filed: August 12, 2003
    Publication date: June 3, 2004
    Applicant: The Regents of the University of Michigan
    Inventor: Kun-Liang Guan
  • Method of inhibiting cancerous cell proliferation using Ras mutants of GDP-bound conformation
    Publication number: 20020150566
    Abstract: Methods for treating proliferative disorders, using GDP-bound Ras proteins, wild-type or mutant, such as RasN17N69, and A15N69 are described. Pharmaceutical compositions and kits for treatment of mammals, such as humans, with Ras-mediated proliferative disorders are also described.
    Type: Application
    Filed: March 25, 2002
    Publication date: October 17, 2002
    Inventors: Kun-Liang Guan, Scott Stewart