Patents by Inventor Kunikazu Sakai

Kunikazu Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6498164
    Abstract: A compound of the formula wherein the substituents are as defined in the specification and solvates and salts thereof useful for treating bone and cartilage diseases.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: December 24, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Kunikazu Sakai, Yusuke Satoh
  • Patent number: 6177474
    Abstract: Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) and quinione analogues derived therefrom (wherein R1 is alkyl, optionally substituted benzyl or optionally substituted aryl; R2 is hydrogen, alkyl, alkenyl or optionally substituted benzyl; R3 is hydrogen, alkyl, alkenyl, optionally substituted benzyl, hydroxyl, alkoxy, alkenyloxy or optionally substituted benzyloxy; R4 is hydrogen, alkyl, alkenyl, optionally substituted benzyl or hydroxyl; and R5 and R6 are each independently hydrogen, alkyl, alkenyl or optionally substituted benzyl). The polyhydroxyphenol derivatives and the quinone analogues exhibit a potent inhibitory activity against bone resorption and are useful as preventive and therapeutic agents for bone and cartilage diseases.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: January 23, 2001
    Assignee: Hoechst Marion Roussel
    Inventors: Kunikazu Sakai, Yusuke Satoh, Kazuyuki Doi, Kazuyuki Kitamura
  • Patent number: 6100219
    Abstract: The present invention provides a plant growth promoter comprising an epoxycylohexane derivative represented by the general formula: ##STR1## (wherein by R.sup.1 represents a hydrogen atom, C1 to C6 alkyl group or C3 to C6 cycloalkyl group, and R.sup.2 and R.sup.3 are independently lower alkyl groups or are combined to form a polymethylene group which may be substituted with an alkyl group) and gibberellin as active ingredients.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: August 8, 2000
    Assignees: Sagami Chemical Research Center, Tama Biochemical Co., Ltd., Bal Planning Co., Ltd.
    Inventors: Kunikazu Sakai, Yasuo Kamuro, Hiroki Kuriyama
  • Patent number: 5965488
    Abstract: The present invention relates to a plant growth regulator comprising as an active ingredient an epoxycyclohexane derivative represented by general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or C.sub.3 -C.sub.6 cycloalkyl group, and R.sup.2 and R.sup.3 are independently C.sub.1 -C.sub.6 alkyl groups or are combined to form a C.sub.2 -C.sub.3 polymethylene group which may be substituted with a C.sub.1 -C.sub.6 alkyl group, as well as to a plant growth regulator comprising the epoxycyclohexane derivative and a brassinosteroid as active ingredients. The epoxycyclohexane derivatives exhibit a potent plant growth regulating action which is equivalent to or higher than that of abscisic acid, and are useful as plant growth regulators such as a plant growth accelerator, a germination growth accelerator, a transpiration and wilting inhibitor, a cold resistance enhancer, an accelerator for growing, thickening or maturing fruits, roots, stems or bulbs, etc.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: October 12, 1999
    Assignees: Sagami Chemical Research Center, Tama Biochemical Co. Ltd., Bal Planning Co., Ltd.
    Inventors: Kunikazu Sakai, Yasuo Kamuro, Suguru Takatsuto, Tsuyoshi Watanabe, Hiroki Kuriyama
  • Patent number: 5801123
    Abstract: The present invention relates to a plant growth regulator comprising as an active ingredient an epoxycyclohexane derivative represented by general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6, alkyl group or C.sub.3 -C.sub.6 cycloalkyl group, and R.sup.2 and R.sup.3 are independently C.sub.1 -C.sub.6 alkyl groups or are combined to form a C.sub.2 -C.sub.3 polymethylene group which may be substituted with a C.sub.1 -C.sub.6, alkyl group, as well as to a plant growth regulator comprising the epoxycyclohexane derivative and a brassinosteroid as active ingredients. The epoxycyclohexane derivatives exhibit a potent plant growth regulating action which is equivalent to or higher than that of abscisic acid, and are useful as plant growth regulators such as a plant growth accelerator, a germination growth accelerator, a transpiration and wilting inhibitor, a cold resistance enhancer, an accelerator for growing, thickening or maturing fruits, roots, stems or bulbs, etc..
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: September 1, 1998
    Assignees: Sagami Chemical Research Center, Tama Biochemical Co. Ltd., Bal Planning Co., Ltd.
    Inventors: Kunikazu Sakai, Yasuo Kamuro, Suguru Takatsuto, Tsuyoshi Watanabe, Hiroki Kuriyama
  • Patent number: 5254694
    Abstract: An optically active epoxycyclohexane derivative represented by the general formula: ##STR1## wherein R represents a 4-oxycarbonyl-1-hydroxy-3-methyl-3(Z)-buten-1-yl or 4-hydroxycarbonyl-3-methyl-1(E),3(Z)-butadien-1-yl group; and R.sup.1 and R.sup.2 each represent a lower alkoxy group or together form a 1,3-dioxolane ring together with the carbon atom to which they are bonded,and an enantiometer thereof.An optically active epoxycyclohexanone derivative represented by the general formula: ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl, allyl, aralkyl or aryl group,and an enantiomer thereof.Further, the process for preparing these compounds, is also disclosed.
    Type: Grant
    Filed: February 12, 1992
    Date of Patent: October 19, 1993
    Assignee: Sagami Chemical Research Center
    Inventors: Kunikazu Sakai, Kyoko Takahashi
  • Patent number: 5231179
    Abstract: A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: July 27, 1993
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Shiro Terashima, Yoshio Ito, Takeo Kawabata, Kunikazu Sakai, Tamejiro Hiyama, Yoshikazu Kimura, Makoto Sunagawa, Katsumi Tamoto, Akira Sasaki
  • Patent number: 4892961
    Abstract: An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: January 9, 1990
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Shiro Terashima, Yoshikazu Kimura, Yoshio Ito, Kunikazu Sakai, Tamejiro Hiyama
  • Patent number: 4540794
    Abstract: A method for preparing a 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I) is disclosed: ##STR1## the method comprises the steps of: providing a sulfonylhydrazone derivative represented by the general formula (II): ##STR2## providing a sulfide represented by the general formula (III):M--S--M' (III)(wherein R is an aryl group, X is a chlorine or bromine atom, M is an alkali metal atom and M' is a hydrogen atom or an alkali metal atom);combining the sulfonylhydrazone derivative represented by the general formula (II) and the sulfide represented by the general formula (III) and allowing a reaction to occur; andobtaining the 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I).
    Type: Grant
    Filed: September 16, 1983
    Date of Patent: September 10, 1985
    Assignee: Lederle (Japan), Ltd.
    Inventors: Kunikazu Sakai, Daiei Tunemoto, Takeo Kobori, Kiyosi Kondo
  • Patent number: 4431659
    Abstract: Compounds of the general formula ##STR1## their method of preparation, and their use to control nematodes in agricultural crops are disclosed and exemplified.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: February 14, 1984
    Assignee: FMC Corporation
    Inventors: Kunikazu Sakai, Minoru Suda, Kiyoshi Kondo
  • Patent number: 4266067
    Abstract: Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted 2-acetylthiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. In the course of the reaction, 2-(dihaloacetyl)thiophenes are formed which are valuable intermediates for the production of not only 2-thiopheneacetic acids but also thioprofenic acid which is known as an anti-inflammatory agent.
    Type: Grant
    Filed: January 7, 1980
    Date of Patent: May 5, 1981
    Assignee: Sagami Chemical Research Center
    Inventors: Tamotsu Fujisawa, Kiyoshi Kondo, Kunikazu Sakai
  • Patent number: 4219659
    Abstract: An .alpha.-(2-thienyl)propionic acid can easily be prepared in a high yield and high selectivity by reacting a 2-(dihaloacetyl)thiophene which is easily obtainable by acetylation and halogenation of a substituted or unsubstutitued thiophene, with a methylmetal compound and then reacting an alkali metal hydroxide with the reaction product. .alpha.-(2-Thienyl)propionic acids are useful compounds from which, for example, thioprofenic acid can easily be prepared. Thioprofenic acid is known as an anti-inflammatory agent. As reaction intermediates, 1-(2-thienyl)-1-dihalomethylethanols can be obtained. Which are novel and useful compounds.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: August 26, 1980
    Assignee: Sagami Chemical Research Center
    Inventors: Tamotsu Fujisawa, Kunikazu Sakai, Akira Kurebayashi