Patents by Inventor Kunio Atsumi

Kunio Atsumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7662841
    Abstract: The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: February 16, 2010
    Assignees: Meiji Seika Kaisha, Ltd., Sagami Chemical Research Center
    Inventors: Eiki Shitara, Kunio Atsumi, Keiichi Ajito, Shinya Ikeda, Tadashi Katoh, Munenori Inoue, Mari Nakatani
  • Patent number: 7563901
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: July 21, 2009
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Toshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
  • Patent number: 7553989
    Abstract: The present invention relates to a compound represented by formula (1) or a salt thereof: wherein R represents a group that is easily removable upon hydrolysis in vivo. This compound is usable in the production of prodrug-type carbapenem antibacterial agents for oral administration. The use of this compound in the process of production of the antibacterial agents can realize enhanced production efficiency and reduced production cost.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: June 30, 2009
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Takehiko Sawabe, Kazuhiro Aihara, Kunio Atsumi, Keiichi Ajito
  • Patent number: 7524951
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: April 28, 2009
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Toshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
  • Publication number: 20090082571
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Application
    Filed: November 3, 2008
    Publication date: March 26, 2009
    Inventors: Toshiro Sasaki, Takashi Ando, Takahiro Imai, Dai Kubota, Eiki Shitara, Kunio Atsumi
  • Patent number: 7482445
    Abstract: This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1?-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial activity in a simpler manner with improved yield and purity.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: January 27, 2009
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazuhiro Aihara, Toshifumi Hasegawa, Shinichi Kitahara, Takashi Watanabe, Takashi Ando, Takehiko Sawabe, Eiki Shitara, Kunio Atsumi, Kazumi Ota
  • Publication number: 20080167475
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Application
    Filed: February 15, 2008
    Publication date: July 10, 2008
    Inventors: Toshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
  • Publication number: 20080114164
    Abstract: The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.
    Type: Application
    Filed: January 19, 2006
    Publication date: May 15, 2008
    Inventors: Eiki Shitara, Kunio Atsumi, Keiichi Ajito, Shinya Ikeda, Tadashi Katoh, Munenori Inoue, Mari Nakatani
  • Patent number: 7365174
    Abstract: Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is hydrogen or straight-chain C1-6 alkylcarbonyl; R2 is hydrogen or C1-6 alkylcarbonyl; R3 is hydrogen, C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkenyl, C2-6 alkenylcarbonyl, C2-6 alkynyl, or an Ar—B— group (wherein Ar is aryl or a heterocyclic group; and B is C1-6 alkyl, C1-6 alkylcarbonyl, C2-6 alkenyl, C2-6 alkenylcarbonyl, or C2-6 alkynyl); R5, R6, R7 and R8 are each hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or an Ar—B?— group (wherein B? is C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl); X is oxygen or —NR4— (wherein R4 is hydrogen, C1-6 alkyl or C1-6 alkyl which may be substituted with Ar); and R4? is hydrogen or a group represented by the general formula (a) (wherein R3? and R4? are each hydrogen or straight-chain or branched C1-6 alkylcarbonyl)
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: April 29, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tomoaki Miura, Kenichi Kanemoto, Satomi Natsume, Naoto Ohkura, Yumiko Fujihira, Takashi Watanabe, Hideki Fushimi, Kunio Atsumi, Keiichi Ajito
  • Publication number: 20080076917
    Abstract: The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
    Type: Application
    Filed: December 15, 2003
    Publication date: March 27, 2008
    Applicant: Meiji Seika Kaisha, Ltd.
    Inventors: Toshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
  • Publication number: 20070167620
    Abstract: This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1?-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial actibity in a simpler manner with improved yield and purity.
    Type: Application
    Filed: June 18, 2004
    Publication date: July 19, 2007
    Applicant: Meiji Seika Kaisha, Ltd.
    Inventors: Kazuhiro Aihara, Toshifumi Hasegawa, Shinichi Kitahara, Takashi Watanabe, Takashi Ando, Takehiko Sawabe, Eiki Shitara, Kunio Atsumi, Kazumi Ota
  • Publication number: 20070042974
    Abstract: A compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, which is useful for a prophylactic and/or therapeutic treatment of a microbial infectious disease.
    Type: Application
    Filed: August 20, 2004
    Publication date: February 22, 2007
    Inventors: Tomoaki Miura, Kenichi Kanemoto, Satomi Natsume, Naoto Ohkura, Yumiko Fujihira, Takashi Watanabe, Hideki Fushimi, Kunio Atsumi, Keiichi Ajito
  • Publication number: 20050272950
    Abstract: The present invention relates to a compound represented by formula (1) or a salt thereof: wherein R represents a group that is easily removable upon hydrolysis in vivo. This compound is usable in the production of prodrug-type carbapenem antibacterial agents for oral administration. The use of this compound in the process of production of the antibacterial agents can realize enhanced production efficiency and reduced production cost.
    Type: Application
    Filed: October 17, 2003
    Publication date: December 8, 2005
    Applicant: MEIJI SEIKA KAISHA LTD.
    Inventors: Takehiko Sawabe, Kazuhiro ihara, Kunio Atsumi, Keiichi Ajito
  • Patent number: 6908913
    Abstract: An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and ?-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl, R2 and R3 each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.
    Type: Grant
    Filed: November 22, 2001
    Date of Patent: June 21, 2005
    Assignee: Meiji Seiki Kaisha, Ltd.
    Inventors: Yuko Kano, Yasuo Yamamoto, Takahisa Maruyama, Takehiko Sawabe, Eiki Shitara, Kazuhiro Aihara, Kunio Atsumi, Takashi Ida
  • Patent number: 6825187
    Abstract: An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl; R2 and R3 each independently represent H, halogen, lower alkyl or the like; R4 represents optionally substituted lower alkylthio or the like; and R5 represents optionally substituted lower alkyl or the like.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: November 30, 2004
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuko Kano, Takahisa Maruyama, Yasuo Yamamoto, Eiki Shitara, Toshiro Sasaki, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
  • Publication number: 20040038967
    Abstract: An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase producing bacteria and are stable to DHP-1.
    Type: Application
    Filed: February 14, 2003
    Publication date: February 26, 2004
    Inventors: Yuko Kano, Yasuo Yamamoto, Takahisa Maruyama, Takehiko Sawabe, Eiki Shitara, Kazuhiro Aihara, Kunio Atsumi, Takashi Ida
  • Patent number: 6680313
    Abstract: An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl; R2 and R3 represent H, a halogen atom, alkyl or the like; and R4 represents substituted lower alkylthio or the like.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: January 20, 2004
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuko Kano, Takahisa Maruyama, Yumiko Sambongi, Kazuhiro Aihara, Kunio Atsumi, Kastuyoshi Iwamatsu, Takashi Ida
  • Patent number: 6677331
    Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: January 13, 2004
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuko Kano, Toshiro Sasaki, Yumiko Sambongi, Kiyoshi Tanabe, Yoshihisa Akiyama, Hideo Kitagawa, Takahisa Maruyama, Hiromasa Takizawa, Takashi Ando, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
  • Publication number: 20030149016
    Abstract: Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1.
    Type: Application
    Filed: August 14, 2002
    Publication date: August 7, 2003
    Inventors: Yuko Kano, Toshiro Sasaki, Yumiko Sambongi, Kiyoshi Tanabe, Yoshihisa Akiyama, Hideo Kitagawa, Takahisa Maruyama, Hiromasa Takizawa, Takashi Ando, Kazuhiro Aihara, Kunio Atsumi, Katsuyoshi Iwamatsu, Takashi Ida
  • Publication number: 20030027809
    Abstract: An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1.
    Type: Application
    Filed: July 25, 2002
    Publication date: February 6, 2003
    Inventors: Yuko Kano, Takahisa Maruyama, Yumiko Sambongi, Kazuhiro Aihara, Kunio Atsumi, Kastuyoshi Iwamatsu, Takashi Ida