Patents by Inventor Kunio Hori
Kunio Hori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11378515Abstract: An image processing device includes: a processor including hardware. The processor is configured to: with respect to each pixel included in a fluorescent image obtained by capturing a tissue group including one or more tissues dyed by using a fluorescent dye group including one or more fluorescent dyes by a fluorescent microscope, estimate a light quantity of fluorescence emitted by each fluorescent dye of the fluorescent dye group; estimate a tissue amount of each tissue of the tissue group based on the estimated light quantity; estimate a virtual dye amount of each dye of a bright-field dye group of a case in which the tissue group dyed by using the bright-field dye group including one or more dyes is captured by a transmission-type microscope based on the estimated tissue amount; and generate a virtual transmitted-light image from the estimated dye amount.Type: GrantFiled: January 19, 2021Date of Patent: July 5, 2022Assignee: OLYMPUS CORPORATIONInventors: Takeshi Otsuka, Kunio Hori
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Publication number: 20210164904Abstract: An image processing device includes: a processor including hardware. The processor is configured to: with respect to each pixel included in a fluorescent image obtained by capturing a tissue group including one or more tissues dyed by using a fluorescent dye group including one or more fluorescent dyes by a fluorescent microscope, estimate a light quantity of fluorescence emitted by each fluorescent dye of the fluorescent dye group; estimate a tissue amount of each tissue of the tissue group based on the estimated light quantity; estimate a virtual dye amount of each dye of a bright-field dye group of a case in which the tissue group dyed by using the bright-field dye group including one or more dyes is captured by a transmission-type microscope based on the estimated tissue amount; and generate a virtual transmitted-light image from the estimated dye amount.Type: ApplicationFiled: January 19, 2021Publication date: June 3, 2021Applicant: OLYMPUS CORPORATIONInventors: Takeshi OTSUKA, Kunio HORI
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Patent number: 9855195Abstract: The present invention provides a dental curable composition used for dental filling restorative materials, dental crown prosthesis materials such as inlays, crowns, and bridges, materials for constructing anchor teeth, block materials for dental CAD/CAM, etc. More specifically, the present invention provides a dental curable composition comprising a curable resin (A), a porous inorganic filler (B), and a polymerization initiator (C), wherein the porous inorganic filler (B) comprises a silicon dioxide, and an oxide comprising at least one kind of the other metallic elements, and a ratio (I1/I2) of a maximum absorbance (I1) of 3730 to 3750 cm?1 to a maximum absorbance (I2) of 3000 to 3600 cm?1 in infrared absorption spectrum of the porous inorganic filler (B), is not less than 1 and not more than 3.Type: GrantFiled: September 16, 2016Date of Patent: January 2, 2018Assignees: KABUSHIKI KAISHA SHOFU, JGC CATALYSTS AND CHEMICALS LTD.Inventors: Shuhei Takahashi, Hidefumi Fujimura, Jun Uchida, Mitsuji Teramae, Kunio Hori, Naoyuki Enomoto
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Patent number: 9771612Abstract: A method for detecting a target nucleic acid comprising: forming a three-component association product by allowing the association of at least a nucleic acid molecule, a first nucleic acid probe having a first marker bound thereto, and a second nucleic acid probe having a second marker bound thereto; forming at least one covalent bond between the target nucleic acid molecule and the first nucleic acid probe and between the target nucleic acid molecule and the second nucleic acid probe; and binding the three-component association product to a solid phase carrier through the second marker; recovering the three-component association product bound to the solid phase carrier; releasing the first marker from the recovered three-component association product; and detecting the target nucleic acid molecule by detecting the free first marker.Type: GrantFiled: September 15, 2014Date of Patent: September 26, 2017Assignee: OLYMPUS CORPORATIONInventors: Kunio Hori, Kenzo Fujimoto
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Publication number: 20170079890Abstract: The present invention provides a dental curable composition used for dental filling restorative materials, dental crown prosthesis materials such as inlays, crowns, and bridges, materials for constructing anchor teeth, block materials for dental CAD/CAM, etc. More specifically, the present invention provides a dental curable composition comprising a curable resin (A), a porous inorganic filler (B), and a polymerization initiator (C), wherein the porous inorganic filler (B) comprises a silicon dioxide, and an oxide comprising at least one kind of the other metallic elements, and a ratio (I1/I2) of a maximum absorbance (I1) of 3730 to 3750 cm?1 to a maximum absorbance (I2) of 3000 to 3600 cm?1 in infrared absorption spectrum of the porous inorganic filler (B), is not less than 2 and not more than 3.Type: ApplicationFiled: September 16, 2016Publication date: March 23, 2017Applicants: KABUSHIKI KAISHA SHOFU, JGC CATALYSTS AND CHEMICALS LTD.Inventors: Shuhei TAKAHASHI, Hidefumi FUJIMURA, Jun UCHIDA, Mitsuji TERAMAE, Kunio HORI, Naoyuki ENOMOTO
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Patent number: 9395357Abstract: There is provided an optical analysis technique enabling the detection of the condition or characteristic of a particle to be observed contained at a low concentration or number density in a sample solution using a light-emitting probe. The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting probe having bound to a particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region), thereby detecting individually the particle crossing the inside of the micro region to enable the counting of the particle(s) or the acquisition of the information on the concentration or number density of the particle.Type: GrantFiled: January 22, 2013Date of Patent: July 19, 2016Assignee: OLYMPUS CORPORATIONInventors: Tetsuya Tanabe, Hidetaka Nakata, Takuya Hanashi, Kunio Hori, Kazutaka Nishikawa
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Publication number: 20150259732Abstract: A number of samples provided for analysis are identified correctly by making use of smaller kinds of nucleic acids. Provided is a nucleic acid analysis kit having a plurality of supports that respectively retain identifier probes containing a nucleic acid and support specimens. The identifier probes contains at least one kind of a nucleic acid having a known base sequence, differ in at least one of the kind and amount of the nucleic acid for each of the supports, and are retained by the supports so as to be mixed with the specimens, respectively.Type: ApplicationFiled: June 3, 2015Publication date: September 17, 2015Applicant: OLYMPUS CORPORATIONInventor: Kunio HORI
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Publication number: 20150004607Abstract: A method for detecting a target nucleic acid comprising: forming a three-component association product by allowing the association of at least a nucleic acid molecule, a first nucleic acid probe having a first marker bound thereto, and a second nucleic acid probe having a second marker bound thereto; forming at least one covalent bond between the target nucleic acid molecule and the first nucleic acid probe and between the target nucleic acid molecule and the second nucleic acid probe; and binding the three-component association product to a solid phase carrier through the second marker; recovering the three-component association product bound to the solid phase carrier; releasing the first marker from the recovered three-component association product; and detecting the target nucleic acid molecule by detecting the free first marker.Type: ApplicationFiled: September 15, 2014Publication date: January 1, 2015Applicant: OLYMPUS CORPORATIONInventors: Kunio Hori, Kenzo Fujimoto
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Patent number: 8710413Abstract: There is provided an optical analysis technique enabling the detection of the condition or characteristic of a particle to be observed contained at a low concentration or number density in a sample solution. The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region), thereby detecting individually the light-emitting particle crossing the inside of the micro region to enable the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: GrantFiled: August 28, 2012Date of Patent: April 29, 2014Assignee: Olympus CorporationInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Patent number: 8541759Abstract: The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, computes a characteristic value of the light intensity indicating the presence or absence of the light from a single light-emitting particle in every time section of a predetermined width in the light intensity data; and detects the light-emitting particle crossing the inside of the micro region individually using the characteristic value, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: GrantFiled: August 28, 2012Date of Patent: September 24, 2013Assignee: Olympus CorporationInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Patent number: 8471220Abstract: The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, and after smoothing the time series light intensity data; and detects in the smoothed time series light intensity data the light-emitting particle crossing the inside of the micro region individually, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: GrantFiled: August 29, 2012Date of Patent: June 25, 2013Assignee: Olympus CorporationInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Publication number: 20130048875Abstract: The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, and after smoothing the time series light intensity data; and detects in the smoothed time series light intensity data the light-emitting particle crossing the inside of the micro region individually, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: OLYMPUS CORPORATIONInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Publication number: 20120319009Abstract: The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, computes a characteristic value of the light intensity indicating the presence or absence of the light from a single light-emitting particle in every time section of a predetermined width in the light intensity data; and detects the light-emitting particle crossing the inside of the micro region individually using the characteristic value, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: ApplicationFiled: August 28, 2012Publication date: December 20, 2012Applicant: OLYMPUS CORPORATIONInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Publication number: 20120318956Abstract: There is provided an optical analysis technique enabling the detection of the condition or characteristic of a particle to be observed contained at a low concentration or number density in a sample solution. The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region), thereby detecting individually the light-emitting particle crossing the inside of the micro region to enable the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle.Type: ApplicationFiled: August 28, 2012Publication date: December 20, 2012Applicant: OLYMPUS CORPORATIONInventors: Mitsushiro Yamaguchi, Seiji Kondo, Tetsuya Tanabe, Kunio Hori
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Publication number: 20110033855Abstract: The present invention is to provide a method for highly sensitively and precisely quantifying nucleic acid molecules in a sample.Type: ApplicationFiled: August 5, 2010Publication date: February 10, 2011Applicant: OLYMPUS CORPORATIONInventors: Kunio HORI, Hidetaka NAKATA, Sayoko KOBAYASHI
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Patent number: 7550276Abstract: The present invention relates to a method of detecting or quantifying a target nucleic acid present in a specimen. The present invention provides a method of detecting or quantifying a target nucleic acid by using artificially-designed probes having a flag consisting of a plurality of units, thereby easily and accurately detecting the target nucleic acid.Type: GrantFiled: November 13, 2003Date of Patent: June 23, 2009Assignee: Olympus CorporationInventors: Akira Suyama, Kunio Hori
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Publication number: 20080076133Abstract: The present invention discloses a method of detecting a polymorphism site. According to an embodiment of the present invention, there is provided a method comprising (1) reacting a test sample containing a polymorphism site with at least one type of probe which is capable of binding to the polymorphism site of the test sample with a high affinity and labeled with a marker substance, and (2) optically measuring and analyzing a positional change of the marker substance at a plurality of time points in the course of the reaction, thereby detecting the polymorphism site.Type: ApplicationFiled: September 10, 2007Publication date: March 27, 2008Applicant: OLYMPUS CORPORATIONInventors: Kunio Hori, Sachiko Karaki, Tokio Kano, Yuji Takamiya
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Publication number: 20050064441Abstract: The present invention relates to a method of detecting or quantifying a target nucleic acid present in a specimen. The present invention provides a method of detecting or quantifying a target nucleic acid by using artificially-designed probes having a flag consisting of a plurality of units, thereby easily and accurately detecting the target nucleic acid.Type: ApplicationFiled: November 13, 2003Publication date: March 24, 2005Applicant: Olympus Optical Co., Ltd.Inventors: Akira Suyama, Kunio Hori
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Publication number: 20030008296Abstract: The present invention discloses a method of detecting a polymorphism site. According to an embodiment of the present invention, there is provided a method comprising (1) reacting a test sample containing a polymorphism site with at least one type of probe which is capable of binding to the polymorphism site of the test sample with a high affinity and labeled with a marker substance, and (2) optically measuring and analyzing a positional change of the marker substance at a plurality of time points in the course of the reaction, thereby detecting the polymorphism site.Type: ApplicationFiled: November 27, 2001Publication date: January 9, 2003Applicant: OLYMPUS OPTICAL CO., LTD.Inventors: Kunio Hori, Sachiko Karaki, Tokio Kano, Yuji Takamiya
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Publication number: 20020031772Abstract: The present invention relates to a method of detecting or quantifying a target nucleic acid present in a specimen. The present invention provides a method of detecting or quantifying a target nucleic acid by using artificially-designed probes having a flag consisting of a plurality of units, thereby easily and accurately detecting the target nucleic acid.Type: ApplicationFiled: June 1, 2001Publication date: March 14, 2002Applicant: OLYMPUS OPTICAL CO., LTD.Inventors: Akira Suyama, Kunio Hori