Patents by Inventor Kyoka HOSHI

Kyoka HOSHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10352927
    Abstract: It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: July 16, 2019
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hisashi Narimatsu, Atsushi Kuno, Yuzuru Ikehara, Yasuhiro Hashimoto, Keiro Shirotani, Kiyomitsu Nara, Yoshinobu Kariya, Hiromi Ito, Kyoka Hoshi
  • Publication number: 20190113528
    Abstract: An object of the present invention is to develop a biomarker for discriminating dementia, particularly, Alzheimer's disease and mild cognitive impairment which can progress to Alzheimer's disease, from other central nervous system diseases, or capable of determining a pathological condition of dementia, and provide a method for diagnosing dementia early and a method for determining a pathological condition of dementia, using the biomarker. A transferrin glycoprotein containing a glycan having at least one mannose at a non-reducing end or a transferrin fragment containing the glycan is used as a diagnostic marker for Alzheimer's disease.
    Type: Application
    Filed: May 9, 2017
    Publication date: April 18, 2019
    Inventors: Yasuhiro HASHIMOTO, Kyoka HOSHI, Hiromi ITO, Takashi HONDA, Yoshiki YAMAGUCHI, Masamichi NAGAE
  • Publication number: 20150338396
    Abstract: It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts.
    Type: Application
    Filed: August 9, 2013
    Publication date: November 26, 2015
    Inventors: Hisashi NARIMATSU, Atsushi KUNO, Yuzuru IKEHARA, Yasuhiro HASHIMOTO, Keiro SHIROTANI, Kiyomitsu NARA, Yoshinobu KARIYA, Hiromi ITO, Kyoka HOSHI