Abstract: An object is to elucidate the immune response mechanism of IL-17-producing cells which causes a pathological condition such as psoriasis, and to provide an immune response suppressant for suppressing the immune response of IL-17-producing cells, a medicament for treating or preventing a disease or a pathological condition involving the immune response of an IL-17-producing cell, a method for inducing immune response in ??T cells, and a method for evaluating a medicament (candidate substance) and a method for producing IL-17 by use of the method.

Abstract: A composition for inhibiting proliferation of influenza virus has fermented rice bran powder produced using non-pathogenic microbes that include, as cellulolytic bacteria, at least three Bacillus species, Bacillus amyloliquefaciens M-4 (deposit number: NITE P-02538 and NITE BP-02538), Bacillus subtilis M-5 (deposit number: NITE P-02539 and NITE BP-02539) and the Bacillus subtilis-related species Bacillus sp. M-6 (deposit number: NITE P-02940 and NITE BP-02940), and at least one Paenibacillus species, Paenibacillus cineris M-9 (deposit numbers: NITE AP-03304 and NITE BP-03304).

Abstract: An antiviral agent according to the present disclosure includes, as an active ingredient, an extract extracted from a microalga Pseudochoricystis ellipsoidea Sekiguchi et Kurano gen. et sp. nov. MBIC11204 strain. The microalga may be cultured in a culture medium comprising sufficient nitrogen or may be cultured in a nitrogen-deficient medium thereafter. The extract is extracted from the microalga with alcohol, hot water, or the like as an extraction solvent. The extract may be extracted from the residue thereof with hot water. The antiviral agent may include the extract obtained using one extraction solvent, or may include a mixture of the extracts obtained using multiple extraction solvents.

Abstract: Methods for administering a polyalkyleneimine to treat or prevent a viral infection, inactivate a virus, inhibit viral adsorption to a cell, and inhibit viral invasion of a cell are presented.

Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

Abstract: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: ? wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

Abstract: The present invention relates to a compound represented by Formula [I] wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1 represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)-amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R2 represents a hydrogen atom or a lower alkyl group, a salt or ester thereof, a production process for the same, and an analge

Abstract: An antiviral polysaccharide purified from an extract prepared by extracting Spirulina cells with hot water, having the following properties:(1) it comprises rhamnose, glucose, fructose, ribose, galactose, xylose, mannose, glucuronic acid and galacturonic acid;(2) it exhibits an absorption at 480 nm in phenolsulfuric acid reaction; and(3) it has a molecular weight of 250,000 to 300,000 Daltons as determined by gel filtration; and pharmaceuticals, food and feed, comprising said antiviral polysaccharide.