Patents by Inventor Kyoko Kohara

Kyoko Kohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8466273
    Abstract: The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells. The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: June 18, 2013
    Assignees: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Tokyo Metropolitan Institute of Medical Science, National University Corporation Kumamoto University
    Inventors: Kyoko Kohara, Michinori Kohara, Tomohiro Nishimura, Masaaki Sato
  • Publication number: 20090234102
    Abstract: The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells. The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.
    Type: Application
    Filed: September 30, 2008
    Publication date: September 17, 2009
    Inventors: Kyoko Kohara, Michinori Kohara, Tomohiro Nishimura, Masaaki Sato
  • Patent number: 6639053
    Abstract: The present invention provides a gene encoding an RNA polymerase which plays an important role in the reproduction of hepatitis C virus, and a method of screening using this gene or this RNA polymerase protein, thereby allowing easy performance of screening for substances which inhibit the RNA polymerase playing an important role in HCV reproduction.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 28, 2003
    Assignees: International Reagents Corporation, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tetsuya Toyoda, Michinori Kohara, Kyoko Kohara, Kazuhiro Higashi, Masayuki Tsuchiya
  • Patent number: 6524853
    Abstract: This invention provides a vector comprising cDNA encoding an RNA viral gene, characterized in that the vector is constructed such that both termini of the RNA viral gene can be transcribed precisely and uniformly. This vector is useful to elucidate the mechanisms of RNA virus replication and of the development of RNA virus infections, and to develop therapeutic agents and means of treatment, and so on.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 25, 2003
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Michinori Kohara, Kyoko Kohara, Kazunari Taira, Junichi Matsuzaki, Hiroshi Ohmori