Patents by Inventor Kyoko Kohara

Kyoko Kohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nasal hepatitis B vaccine composition and method for producing same
    Patent number: 11491219
    Abstract: The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: November 8, 2022
    Assignees: TOKYO YAKUHIN KOGYO CO., LTD., TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases, KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY
    Inventors: Taizou Kamishita, Takashi Miyazaki, Michinori Kohara, Takahiro Sanada, Yoichi Hiasa, Osamu Yoshida, Kyoko Kohara, Hideki Hasegawa
  • DENGUE VIRUS VACCINE
    Publication number: 20220152187
    Abstract: The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicants: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, KAGOSHIMA UNIVERSITY, NAGASAKI UNIVERSITY
    Inventors: Michinori KOHARA, Fumihiko YASUI, Daisuke YAMANE, Kyoko KOHARA, Kouichi MORITA, Yasuhiro YASUTOMI, Koji ISHII
  • HEPATITIS B VACCINE
    Publication number: 20210228712
    Abstract: A hepatitis B vaccine comprising a surface antigen particle that has only hepatitis B virus L protein or a variant thereof assembling on a lipid membrane to form the particle.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 29, 2021
    Inventors: Michinori Kohara, Takahiro Sanada, Yoichi Hiasa, Kyoko Kohara, Yasumasa Goh, Yasunori Oda
  • NASAL HEPATITIS B VACCINE COMPOSITION AND METHOD FOR PRODUCING SAME
    Publication number: 20200261568
    Abstract: The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.
    Type: Application
    Filed: October 4, 2018
    Publication date: August 20, 2020
    Inventors: Taizou KAMISHITA, Takashi MIYAZAKI, Michinori KOHARA, Takahiro SANADA, Yoichi HIASA, Osamu YOSHIDA, Kyoko KOHARA, Hideki HASEGAWA
  • Hepatitis C virus inhibitors
    Patent number: 8466273
    Abstract: The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells. The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: June 18, 2013
    Assignees: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Tokyo Metropolitan Institute of Medical Science, National University Corporation Kumamoto University
    Inventors: Kyoko Kohara, Michinori Kohara, Tomohiro Nishimura, Masaaki Sato
  • HEPATITIS C VIRUS INHIBITORS
    Publication number: 20090234102
    Abstract: The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells. The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.
    Type: Application
    Filed: September 30, 2008
    Publication date: September 17, 2009
    Inventors: Kyoko Kohara, Michinori Kohara, Tomohiro Nishimura, Masaaki Sato
  • HCV-derived RNA polymerase gene
    Patent number: 6639053
    Abstract: The present invention provides a gene encoding an RNA polymerase which plays an important role in the reproduction of hepatitis C virus, and a method of screening using this gene or this RNA polymerase protein, thereby allowing easy performance of screening for substances which inhibit the RNA polymerase playing an important role in HCV reproduction.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 28, 2003
    Assignees: International Reagents Corporation, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tetsuya Toyoda, Michinori Kohara, Kyoko Kohara, Kazuhiro Higashi, Masayuki Tsuchiya
  • Vector expressing the full-length gene of RNA virus and use thereof
    Patent number: 6524853
    Abstract: This invention provides a vector comprising cDNA encoding an RNA viral gene, characterized in that the vector is constructed such that both termini of the RNA viral gene can be transcribed precisely and uniformly. This vector is useful to elucidate the mechanisms of RNA virus replication and of the development of RNA virus infections, and to develop therapeutic agents and means of treatment, and so on.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 25, 2003
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Michinori Kohara, Kyoko Kohara, Kazunari Taira, Junichi Matsuzaki, Hiroshi Ohmori